Lipospheres and pro-nano lipospheres for delivery of poorly water soluble compounds

Elgart, Anna; Cherniakov, Irina; Aldouby, Yanir; Domb, Abraham J.; Hoffman, Amnon

doi:10.1016/j.chemphyslip.2012.01.007

Cited by 78 publications

(64 citation statements)

References 114 publications

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“…Modulation of the surface charge is used to stabilize colloidal systems of nanoparticles (Elgart et al, 2012), to prolong the circulation time (Malik et al, 2000), and to increase cellular uptake (Lin et al, 2013). At the same time, the charge can be the critical factor for electrically excitable cardiac tissue.…”

mentioning

confidence: 99%

“…The recommended size of the particles for intravenous administration should not exceed the diameter of the fine capillaries (9 mm), preferentially staying in submicron range to avoid their possible blockage, which could lead to a fat embolism and result in death (Mehnert and Mader, 2001). This cutoff is the most critical for the particles with limited deformability or particles tending to aggregate, such as lipidbased drug carriers (Elgart et al, 2012).…”

mentioning

confidence: 99%

“…Design of charged nanoparticles is gaining popularity in drug delivery applications (Malik et al, 2000;Elgart et al, 2012;Lin et al, 2013). Modulation of the surface charge is used to stabilize colloidal systems of nanoparticles (Elgart et al, 2012), to prolong the circulation time (Malik et al, 2000), and to increase cellular uptake (Lin et al, 2013).…”

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confidence: 99%

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Novel Delivery Systems for Improving the Clinical Use of Peptides

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Novel Delivery Systems for Improving the Clinical Use of Peptides

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“…Multifunctional nanoemulsions for oral and intravenous delivery: Gadolinium-loaded nanoemulsion has been utilized for brain imaging in animal studies [114][115][116][117][118][119][120][121][122][123][124][125][126][127][128][129][130][131][132][133]134]. This imaging technology could be utilized for imaging within the eye to observe the results of various drug delivery modalities.…”

Section: Applications Of Nanoparticulate Transscleral Drug Delivery Smentioning

confidence: 99%

Nanoparticulate Transscleral Ocular Drug Delivery

Shah¹,

Shah²,

Groshev³

et al. 2014

J Biomol Res Ther

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Ocular drug delivery is one of the most challenging areas of drug delivery due to the unique mostly avascular nature of the major eye structures and presence of two blood barriers. Effectiveness of a more conventional systemic delivery falls short due to low drug levels in the eye tissue. Periocular approaches require penetration of fibrous sclera and present their own limitations. Utilization of nanotechnology presents new avenue of drug system development with potential to penetrate protective barriers and sustain ample tissue saturation. More specifically, transscleral delivery permits a range of applications in targeted delivery, gene, stem cell, protein and peptides, oligonucleotide, and ribozyme therapies. The exciting range of current applications is expounded in this review.

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“…In http://dx.doi.org/10.1016/j.ejpb.2016.02.012 0939-6411/Ó 2016 Elsevier B.V. All rights reserved. particular, solid lipid nanoparticles (SLN) have emerged as an interesting and effective alternative to other particulate delivery systems such as nanoemulsions, micelles, liposomes, and polymeric nanoparticles [16,30]. It has been claimed that SLN should overcome some of the major disadvantages of other colloidal carriers, such as in particular the low stability and possible biotoxicity [31,30], and offer several advantages such as high drug loading, protection from degradation and release modulation [1,50,9,30].…”

Section: Introductionmentioning

confidence: 99%

Development of solid lipid nanoparticles as carriers for improving oral bioavailability of glibenclamide

Gonçalves

Maestrelli

Mannelli

et al. 2016

European Journal of Pharmaceutics and Biopharmaceutics

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a b s t r a c tA solid lipid nanoparticle (SLN) formulation was developed with the aim of improving the oral bioavailability and the therapeutic effectiveness of glibenclamide (GLI), a poorly water-soluble drug used in the treatment of type 2 diabetes. The SLN was prepared using different lipid components (Precirol Ò and Compritol Ò) and preparation procedures. Precirol-based SLN, obtained with the emulsion of solvent evaporation technique gave the best results and was selected for drug loading. Addition of lecithin to the SLN core or PEG coating was effective in increasing the nanoparticles stability in simulated gastric solution. Both such formulations were stable after one month storage at 5 ± 3°C, exhibited the absence of in vitro cytotoxicity, and presented a similar in vitro prolonged-release, reaching 100% release after 24 h. The lecithin-containing GLI-loaded SLN formulation, selected for in vivo studies in virtue of its higher EE% than the PEG-coated formulation (70.3% vs 19.6%), showed a significantly stronger hypoglycemic effect with respect to the drug alone, in terms of both shorter onset time and longer duration of the effect. These positive results indicated that the proposed SLN approach was successful in improving GLI oral bioavailability, confirming its potential as an effective delivery system for a suitable therapy of diabetes.

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Lipospheres and pro-nano lipospheres for delivery of poorly water soluble compounds

Cited by 78 publications

References 114 publications

Novel Delivery Systems for Improving the Clinical Use of Peptides

Novel Delivery Systems for Improving the Clinical Use of Peptides

Nanoparticulate Transscleral Ocular Drug Delivery

Development of solid lipid nanoparticles as carriers for improving oral bioavailability of glibenclamide

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