Lipotoxicity-associated inflammation is prevented by guarana (<i>Paullinia cupana</i>) in a model of hyperlipidemia

Ruchel, Jader Betsch; Bernardes, Viviane M.; Braun, Josiane Bizzi Schlemmer; Manzoni, Alessandra Guedes; Passos, Daniela F.; Castilhos, Lívia Gelain; Abdalla, Fátima Husein; Oliveira, Juliana Sorraila de; Andrade, Cínthia Melazzo de; Casali, Émerson André; Cruz, Ivana Beatrice Mânica da

doi:10.1080/01480545.2019.1624767

Cited by 15 publications

(11 citation statements)

References 52 publications

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“…This disorder represents a major risk factor for atherosclerosis, ischemic heart disease, and obesity. Conversely, obesity is defined as a metabolic disorder associated with adverse effects related to cardiovascular diseases (e.g., stroke), type 2 diabetes, cancer, gallbladder diseases, osteoarthritis, pulmonary diseases, and sleep apnea (Alonso‐Castro et al., 2019; Bortolin et al., 2019; Ruchel et al., 2019). In less than 45 years, the worldwide obesity prevalence has increased three‐fold; almost 700 million adults were obese in 2016 and 40 million children (5 years old or younger) were overweight or obese in 2019 (World Health Organization, 2020b).…”

Section: Effects On Human Healthmentioning

confidence: 99%

“…These health benefits may prevent the development of chronic diseases caused by lipid profile changes. Several studies applying different experimental models have demonstrated these effects in animals and overweight or obese subjects using guarana alone or in combination with other medicinal plants (Alonso‐Castro et al., 2019; Bortolin et al., 2019; Ruchel et al., 2019).…”

Section: Effects On Human Healthmentioning

confidence: 99%

“…Several studies have demonstrated the positive effects of guarana consumption on heart disease over the past two decades. Ruchel et al (2019) evaluated the effect of guarana powder in the purine metabolism and inflammatory profile in lymphocytes and serum of rats with Poloxamer-407-induced hyperlipidemia. They reported that guarana (12.5, 25, and 50 mg/kg/day) and caffeine (0.2 mg/kg/day) prevented a hyperlipidemia-induced increase in INF-c levels, halting the inflammatory process caused by lipotoxicity and promoting an anti-inflammatory response.…”

Section: Cardiovascular Health and Obesitymentioning

confidence: 99%

“…In an adult male Wistar rat model, guarana powder (12.5, 25, and 50 mg/kg/day) consumption reduced total cholesterol and LDL‐c levels similar to that of simvastatin, partially reduced hyperlipidemia‐induced liver damage, prevented changes in acetylcholinesterase activity, and improved memory impairment related to hyperlipidemia (Ruchel et al., 2019). Furthermore, guarana powder contributed to inflammatory process reduction by decreasing ATP levels and increasing extracellular adenosine, as well as decreasing total cholesterol and LDL‐c to basal levels (Ruchel et al., 2016).…”

Section: Effects On Human Healthmentioning

confidence: 99%

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Effects of the consumption of guarana on human health: A narrative review

Torres

Pinaffi-Langley

Figueira

et al. 2021

Comp Rev Food Sci Food Safe

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Guarana (Paullinia cupana) is a plant from the Amazon region with cultural importance. Despite its early ancestral use by indigenous tribes, the first reports regarding the benefits of guarana consumption for human health were published in the 19th century. Since then, the use of guarana seed in powder and extract forms has been studied for its diverse effects on human health, such as stimulating, anti-inflammatory, antioxidant, anticancer, hypocholesterolemic, and antiobesity effects. These effects are attributed to the high content of bioactive compounds found in guarana seeds, especially methylxanthines and flavonoids. In fact, the Brazilian Food Supplement Law has officially acknowledged guarana as a source of bioactive compounds. The number and diversity of studies focused on guarana and human health are increasing; thus, organizing and describing the available evidence on guarana and its applications is necessary to provide a framework for future studies. In this narrative review, we have organized the available information regarding guarana and its potential effects on human health. Guarana produces unique fruits with great potential for human health applications. However, the available evidence lacks human studies and mechanistic investigations. Future studies should be designed considering its applicability to human health, including intake levels and toxicity studies.

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Section: Effects On Human Healthmentioning

confidence: 99%

Section: Effects On Human Healthmentioning

confidence: 99%

Section: Cardiovascular Health and Obesitymentioning

confidence: 99%

Section: Effects On Human Healthmentioning

confidence: 99%

See 2 more Smart Citations

Effects of the consumption of guarana on human health: A narrative review

Torres

Pinaffi-Langley

Figueira

et al. 2021

Comp Rev Food Sci Food Safe

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“…Desde então, diversos estudos vêm sendo realizados mostrando os efeitos benéficos do guaraná na saúde humana. pode prevenir doenças crônicas causadas por alterações no perfil lipídico(ALONSO-CASTRO et al, 2019;BORTOLIN et al, 2019;RUCHEL et al, 2019).…”

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Efeitos do extrato aquoso de guaraná (Paullinia cupana) em pó nos mecanismos envolvidos com a absorção de colesterol in vitro e em células Caco-2

Figueira¹

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Primeiramente agradeço a Deus, por permitir que eu chegasse até aqui, abrindo portas neste caminho que escolhi seguir; Agradeço à minha mãe Fatima, meu exemplo de mulher forte e mãe dedicada e zelosa, por todo apoio e compreensão, desde o momento em que falei que iria prestar o processo seletivo até o momento da minha mudança; sei que não foi fácil para nós a minha saída de casa e a mudança de cidade, mas ela esteve ao meu lado o tempo todo; À minha irmã Paula, por sempre "segurar a barra" em casa e por ser a minha mais empolgada companheira de passeios nesta grande São Paulo; Ao meu pai Wagner, pelo incentivo aos estudos desde criança, sempre nos dando exemplo de dedicação ao trabalho, sendo determinante para que eu sempre buscasse cada vez mais; mesmo de longe, a torcida pelo sucesso é grande; À toda a minha família, pelo carinho e torcida sempre;

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Berberine attenuates inflammation and oxidative stress and modulates lymphocyte E‐NTPDase in acute hyperlipidemia

Alruhaimi,

Siddiq Abduh,

Ahmeda

et al. 2024

Drug Development Research

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Hyperlipidemia is a common clinically encountered health condition worldwide that promotes the development and progression of cardiovascular diseases, including atherosclerosis. Berberine (BBR) is a natural product with acknowledged anti‐inflammatory, antioxidant, and metabolic effects. This study evaluated the effect of BBR on lipid alterations, oxidative stress, and inflammatory response in rats with acute hyperlipidemia induced by poloxamer‐407 (P‐407). Rats were pretreated with BBR (25 and 50 mg/kg) for 14 days and acute hyperlipidemia was induced by a single dose of P‐407 (500 mg/kg). BBR ameliorated hypercholesterolemia, hypertriglyceridemia, and plasma lipoproteins in P‐407‐adminsitered rats. Plasma lipoprotein lipase (LPL) activity was decreased, and hepatic 3‐hydroxy‐3‐methylglutaryl CoA (HMG‐CoA) reductase activity was enhanced in hyperlipidemic rats. The expression of low‐density lipoprotein receptor (LDL‐R) and ATP‐binding cassette transporter 1 (ABCA1) was downregulated in hyperlipidemic rats. BBR enhanced LPL activity, upregulated LDL‐R, and ABCA1, and suppressed HMG‐CoA reductase in P‐407‐administered rats. Pretreatment with BBR ameliorated lipid peroxidation, nitric oxide (NO), pro‐inflammatory mediators (interleukin [IL]‐6, IL‐1β, tumor necrosis factor [TNF]‐α, interferon‐γ, IL‐4 and IL‐18) and enhanced antioxidants. In addition, BBR suppressed lymphocyte ecto‐nucleoside triphosphate diphosphohydrolase (E‐NTPDase) and ecto‐adenosine deaminase (E‐ADA) as well as NO and TNF‐α release by macrophages isolated from normal and hyperlipidemic rats. In silico investigations revealed the binding affinity of BBR toward LPL, HMG‐CoA reductase, LDL‐R, PSK9, ABCA1, and E‐NTPDase. In conclusion, BBR effectively prevented acute hyperlipidemia and its associated inflammatory responses by modulating LPL, cholesterolgenesis, cytokine release, and lymphocyte E‐NTPDase and E‐ADA. Therefore, BBR is an effective and safe natural compound that might be employed as an adjuvant against hyperlipidemia and its associated inflammation.

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Lipotoxicity-associated inflammation is prevented by guarana (Paullinia cupana) in a model of hyperlipidemia

Cited by 15 publications

References 52 publications

Effects of the consumption of guarana on human health: A narrative review

Effects of the consumption of guarana on human health: A narrative review

Efeitos do extrato aquoso de guaraná (Paullinia cupana) em pó nos mecanismos envolvidos com a absorção de colesterol in vitro e em células Caco-2

Berberine attenuates inflammation and oxidative stress and modulates lymphocyte E‐NTPDase in acute hyperlipidemia

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