Lipoxygenase metabolism following laser induced retinal injury in rabbits

Naveh, Nava; Weissman, C.; Marshall, John C.

doi:10.1076/0271-3683(200007)21:1;1-z;ft554

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…COXs and LOXs are proteins produced in ocular tissues [31,32] . These enzymes are overexpressed in some retinal disorders, mainly of vascular origin [33,34] . Prostaglandins are the major eicosanoids that are synthesized in inflammatory processes from PUFAs.…”

Section: Discussionmentioning

confidence: 99%

Nutrition for the Eye: Different Susceptibility of the Retina and the Lacrimal Gland to Dietary Omega-6 and Omega-3 Polyunsaturated Fatty Acid Incorporation

et al. 2009

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The purpose of this study was to compare the susceptibility of the retina and the exorbital lacrimal gland to dietary supplies of long-chain omega-3 (ω3) and omega-6 (ω6) polyunsaturated fatty acids (LC-PUFAs). Male Wistar rats were fed a 5% lipid diet containing: (1) 10% eicosapentaenoic acid (EPA) and 7% docosahexaenoic acid (DHA), or (2) 10% γ-linolenic acid (GLA), or (3) 10% EPA, 7% DHA and 10% GLA or (4) a balanced diet deprived of EPA, DHA and GLA for 3 months. Lipids were extracted from plasma phospholipids, retina and exorbital lacrimal gland, and fatty acid composition was determined by gas chromatography. Dietary supplementation with EPA and DHA increased ω3 PUFA levels in plasma phospholipids as well as in the retina and the exorbital lacrimal gland. By contrast, GLA supplementation favored ω6 PUFA incorporation, and particularly the incorporation of the end-chain ω6 product, docosapentaenoic acid (DPA), into all tissues. Supplementation with EPA, DHA and GLA increased the levels of DHA, EPA and dihomo-GLA (dGLA), whereas arachidonic acid (AA) was unchanged and DPA decreased in the retina and the lacrimal gland. The ability of both tissues to incorporate PUFAs from blood was evaluated. The results showed that the retina was more selective than the lacrimal gland for EPA. In spite of the different susceptibility of the retina and the lacrimal gland to dietary PUFAs, these results suggest that the concomitant use of dietary ω3 and ω6 PUFAs may be useful in modulating inflammation in both tissues.

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Section: Discussionmentioning

confidence: 99%

Nutrition for the Eye: Different Susceptibility of the Retina and the Lacrimal Gland to Dietary Omega-6 and Omega-3 Polyunsaturated Fatty Acid Incorporation

et al. 2009

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“…Release of AA takes place in the retina under experimental conditions including anoxia and light exposure, and RPE exposed to light released LTC 4 suggesting an involvement in reactive oxygen intermediate phagocytosis [40]. Laser irradiation of the rabbit retina induces alteration in the lipoxygenase pathway pointing to a role of LTB 4 as a mediator in the chorioretinal inflammatory reaction [41]. Although advances have been made on the function of AA derivates in the central nervous system, it is yet to be determined to what extent they participate in ARMD.…”

Section: Cell-derived Mediators Of Inflammationmentioning

confidence: 99%

Inflammation in Dry Age-Related Macular Degeneration

Rodrigues¹

2007

Ophthalmologica

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Purpose: To summarize the current information regarding the role of immune and inflammatory response in the pathogenesis of dry age-related macular degeneration (ARMD). Methods: A Pubmed search was conducted of the period January 1999 to 2005. Relevant information in the literature on the role of inflammation in early dry ARMD was reviewed. Results: Some important evidence for inflammation in early ARMD consists in the isolation of immunoglobulins, complement proteins, cytokines and activated microglia, in retinal pigment epithelium (RPE) cells and drusen. Pivotal mechanisms in early ARMD include the accumulation of debris and proteins along the RPE surface, followed by immune-complex deposition and complement activation. In contrast, the role of other plasma enzymes such as kallikrein-kinin-bradykinin, the Hageman factor, peptides and coagulation proteins in drusen formation and ARMD has yet to be determined. Conclusion: A clear role for inflammatory mediators and cells has been established in recent years. Future studies should elucidate further mechanisms in ARMD development.

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Variation in Lipid-Associated Genes as They Relate to Risk of Advanced Age-Related Macular Degeneration

SanGiovanni

Mehta

2008

World Review of Nutrition and Dietetics

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Lipoxygenase metabolism following laser induced retinal injury in rabbits

Cited by 3 publications

References 19 publications

Nutrition for the Eye: Different Susceptibility of the Retina and the Lacrimal Gland to Dietary Omega-6 and Omega-3 Polyunsaturated Fatty Acid Incorporation

Nutrition for the Eye: Different Susceptibility of the Retina and the Lacrimal Gland to Dietary Omega-6 and Omega-3 Polyunsaturated Fatty Acid Incorporation

Inflammation in Dry Age-Related Macular Degeneration

Variation in Lipid-Associated Genes as They Relate to Risk of Advanced Age-Related Macular Degeneration

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