Lipoxygenases and Cardiovascular Diseases

Laguna-Fernández, Andrés; Petri, Marcelo H.; Thul, Silke; Bäck, Magnus

doi:10.1007/978-3-319-27766-0_6

Cited by 1 publication

(2 citation statements)

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“…Dietary supplementation with omega-3-rich fish oil in atherosclerosis-prone mice leads to increased incorporation of DHA and EPA in the aorta and the heart, whereas the AA content is decreased [ 13 ]. Despite somewhat variable results, the main conclusion, which emerges from the majority of the studies, is a beneficial effect of dietary omega-3 fatty acids on murine atherosclerosis [ 14 ]. In addition to this reduction in atherosclerotic lesion size, morphological characteristics of more stable lesions have also been observed [ 14 ].…”

Section: Experimental Studies Of Omega-3 In Atherosclerosismentioning

confidence: 99%

“…Despite somewhat variable results, the main conclusion, which emerges from the majority of the studies, is a beneficial effect of dietary omega-3 fatty acids on murine atherosclerosis [ 14 ]. In addition to this reduction in atherosclerotic lesion size, morphological characteristics of more stable lesions have also been observed [ 14 ]. In addition, fish oil supplementation prevents the rise in aortic levels of MMP-2 after exposure to chronic intermittent hypoxia [ 13 ], which could constitute one of the mechanisms behind a potential plaque-stabilizing effect of omega-3 supplementation ( Figure 1 ).…”

Section: Experimental Studies Of Omega-3 In Atherosclerosismentioning

confidence: 99%

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Omega-3 Fatty Acids in Atherosclerosis and Coronary Artery Disease

Bäck

2017

Future Sci. OA

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Omega-3 polyunsaturated fatty acids have emerged as possible protective factors associated with a decreased risk for myocardial infarction in populations with a high marine food intake, which may relate to effects on lipid metabolism, thrombosis and inflammation. Omega-3 fatty acids decrease triglyceride levels and also compete as substrates for enzymes involved in the biosynthesis of lipid mediators. The balance between omega-3-derived specialized proresolving mediators and pro-inflammatory lipid mediators from arachidonic acid metabolism can be measured as the resolvin-to-leukotriene ratio, which has been shown to predict subclinical atherosclerosis. The results of experimental, observational and randomized studies of omega-3 fatty acids are somewhat variable and should be interpreted in view of the models used and the populations studied.

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Section: Experimental Studies Of Omega-3 In Atherosclerosismentioning

confidence: 99%