Liprin-β1 is upregulated in human hepatocellular carcinoma and is associated with advanced tumor stage

Abstract

Liprin-β1 is one of the broadly-expressed liprin family members. Dysregulation of liprin-β1 has been implicated in several types of human cancers. However, the expression of liprin-β1 and its clinicopathological significance in human hepatocellular carcinoma (HCC) remains elusive. We evaluated the protein expression of liprin-β1 in HCC and non-tumor liver tissues by immunohistochemistry, and investigated the relationship between liprin-β1 expression and the clinicopathological attributes of HCC. We found that liprin-β1 expression was significantly higher in HCC than in non-tumor liver tissues. Further analysis showed that higher levels of liprin-β1 in HCC were significantly associated with the advanced clinical stage. Interestingly, liprin-β1 was not detected in cholangiocellular carcinoma specimens. These findings suggest that an elevated expression of liprin-β1 may be involved in HCC progression, providing the rationale that upregulation of liprin-β1 may serve as a novel biomarker for human HCC.

Reduced Osteoglycin Protein Expression Correlates with Lymph Node Metastasis and Low Differentiation in Human Gastric Cancer

“…IHC quanti cation and statistical analysis IHC staining was evaluated in a semiquantitative method by scoring the intensity on a scale from 0 to 3 (0, negative; 1, weak or scattered staining in a minority of cells; 2, moderate or strong staining in a majority of cells; and 3, strong staining in all cells), as reported previously. [22] For the statistical analysis, the patients were strati ed into OGNLow (score of 0-1) vs OGNHigh (score of 2-3) groups. The statistical analyses were conducted using GraphPad Prism software version 6.0, and the differences between the expression of OGN and the clinic-pathological variables were examined using the Chi-Squared test and the Student's t-test.…”

PPFIBP1 induces glioma cell migration and invasion through FAK/Src/JNK signaling pathway

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