This chapter will focus on the injection techniques for perioral rejuvenation using botulinum toxin and dermal filler injections. The perioral region is a very mobile region that shows aging changes at various levels. The most common concerns of patients include perioral wrinkling, mouth corners turning down, lip inversion and volume loss. The correct use of botulinum toxin A could minimize perioral wrinkles, give slight eversion (“lip flip”) and help to reduce mouth corner drooping. Fillers can be utilized to treat perioral volume loss and to manage the fine wrinkles around the lips. These procedures require in-depth knowledge of the perioral anatomy and the layers of structures, good knowledge of the products and their respective pharmacokinetics and rheology, and lastly, good injection skills. This will ensure minimizing side effects or complications.