The term desquamative Gingivitis (GD) is used in the area of oral medicine to explain a periodontal clinical condition not associated with biofilm, which is usually observed in a group of patients presenting with autoimmune diseases such as: lichen Oral plane, Pemphigus vulgaris, and mucous membrane pemphigoid, among others. Desquamative gingivitis is most commonly mistaken for other plaque-related types of gingivitis, preventing a correct diagnosis of the lesion and consequently underlying systemic processes, some of which present an important Morbidity and even mortality.