Liquid assisted ventilation: An alternative ventilatory strategy for acute meconium aspiration injury

Foust, Raymond; Tran, Nghia; Cox, Cynthia; Miller, Thomas F.; Greenspan, Jay S.; Wolfson, Marla R.; Shaffer, Thomas H.

doi:10.1002/(sici)1099-0496(199605)21:5<316::aid-ppul7>3.0.co;2-k

Cited by 94 publications

(52 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many animal studies have shown improvement in oxygenation, CO2 removal and lung compliance. [15][16][17][18][19][20][21] It has also been shown to be more effective than surfactant alone in a premature lamb model of respiratory distress syndrome. 19 Studies that looked at lung histology have shown significantly less damage in lungs after PLV.…”

Section: Animal Studiesmentioning

confidence: 99%

“…19 Studies that looked at lung histology have shown significantly less damage in lungs after PLV. 16,17 The need for lower peak inspiratory pressures to achieve adequate tidal volumes has been demonstrated. 15 Abstract: Research on using liquid ventilation to provide artificial respiration in mammals has been ongoing since the 1960s.…”

Section: Animal Studiesmentioning

confidence: 99%

“…22 In all animal studies haemodynamic stability of PLV animals has been demonstrated to be equal to control animals. [15][16][17][18][19][20][21][22] Partial liquid ventilation has been shown to have increased improvement on oxygenation when combined with nitric oxide in pulmonary hypertension in piglets. 22 Whilst most of these studies have demonstrated benefits of PLV over only a few hours, two studies have demonstrated the feasibility of longer periods of PLV.…”

Section: Animal Studiesmentioning

confidence: 99%

“…42 Less dense exudate and debris may be lavaged from peripheral airways and float to the top of the PFC to allow removal by suction. 17,42 Other uses of perfluorocarbons in the lung Drug delivery to the pulmonary circulation has been demonstrated with TLV in neonatal lambs (with acetylcholine, adrenaline and priscoline). 43 The potential for delivery of drugs to the pulmonary vasculature with PLV enhances the prospect of treating patients with pulmonary hypertension.…”

Section: How Partial Liquid Ventilation Workmentioning

confidence: 99%

See 3 more Smart Citations

Liquid ventilation

Davies¹

1999

J Paediatrics Child Health

View full text Add to dashboard Cite

: Research on using liquid ventilation to provide artificial respiration in mammals has been ongoing since the 1960s. The development of inert perfluorocarbon (PFC) liquids with high oxygen and carbon dioxide solubility has made gas exchange with liquid ventilation possible. In 1991 the technique of partial liquid ventilation was introduced where PFC are instilled into the lungs whilst continuing with conventional mechanical ventilation. Partial liquid ventilation has been shown to improve gas exchange and lung function with decreased secondary lung injury, in animal models of acute lung injury and surfactant deficiency. It has been used in uncontrolled trials in preterm neonates, and preliminary results are available from a randomized controlled trial of partial liquid ventilation in paediatric acute respiratory distress syndrome. Perfluorocarbons can also be used to deliver drugs to the lungs, to lavage inflammatory exudate and debris from the lungs, and as an intrapulmonary X‐ray contrast medium. Many questions about partial liquid ventilation remain unanswered particularly with regard to the dose of PFC required, its ideal method of administration and the long‐term effects. Partial liquid ventilation promises to be an exciting new therapy for infants and children with a variety of respiratory problems. The technique requires ongoing research and experimentation.

show abstract

Section: Animal Studiesmentioning

confidence: 99%

Section: Animal Studiesmentioning

confidence: 99%

Section: Animal Studiesmentioning

confidence: 99%

Section: How Partial Liquid Ventilation Workmentioning

confidence: 99%

See 2 more Smart Citations

Liquid ventilation

Davies¹

1999

J Paediatrics Child Health

View full text Add to dashboard Cite

show abstract

“…Many animal studies using various models of lung injury and surfactant lack have shown improvement in oxygenation, carbon dioxide clearance and lung compliance. (Foust, 1996;Tutuncu, 1993;Smith, 1997a;Leach, 1993;Curtis, 1994a;Curtis, 1994b) Partial liquid ventilation is more effective in improving gas exchange and lung function than surfactant alone. There is significantly less damage on lung histology to lungs after partial liquid ventilation.…”

Section: Animal Studiesmentioning

confidence: 99%

Partial Liquid Ventilation in the Extremely Preterm Infant: Potential Benefits and Harms

Davies¹

2012

Lung Diseases - Selected State of the Art Reviews

View full text Add to dashboard Cite

Comparison of perfluorochemical fluids used for liquid ventilation: Effect of endotracheal tube flow resistance

et al. 1997

Self Cite

View full text Add to dashboard Cite

Neonatal endotracheal tubes with small inner diameters are associated with increased resistance regardless of the medium used for assisted ventilation. During liquid ventilation (LV) reduced interfacial tension and pressure drop along the airways result in lower alveolar inflation pressure compared with gas ventilation (GV). This is possible by optimizing liquid ventilation strategies to overcome the resistive forces associated with liquid density (ρ) and viscosity (μ) of these fluids. Knowledge of the effect of ρ, μ, and endotracheal tube (ETT) size on resistance is essential to optimize LV strategies. To evaluate these physical properties, three perfluorochemical (PFC) fluids with a range of kinematic viscosities (FC‐75 = 0.82, LiquiVent™ = 1.10, APF‐140 = 2.90) and four different neonatal ETT tubes (Mallincrokdt Hi‐Lo Jet™ ID 2.5, 3.0, 3.5, and 4.0 mm) were studied. Under steady‐state flow, flow and pressure drop across the ETTs were measured simultaneously. Resistance was calculated by dividing pressure drop by flow, and both pressure‐flow and resistance‐flow relationships were plotted. Also, pressure drop and resistance were each plotted as a function of kinematic viscosity at flows of 0.01 L · s−1 for all four ETT sizes. Data demonstrated a quadratic relationship with respect to pressure drop versus flow, and a linear relationship with resistance versus flow; both were significantly correlated (R = 0.92; P < 0.01) and were inversely related to ETT size. Additionally, there was a significant correlation between pressure drop or resistance and kinematic viscosity (R = 0.99; P < 0.01). For LV in neonates these data can be used to select the optimum ETT size and PFC liquid depending on the chosen ventilation strategy. Pediatr. Pulmonol. 1997; 23:449–456. © 1997 Wiley‐Liss, Inc.

show abstract

Liquid assisted ventilation: An alternative ventilatory strategy for acute meconium aspiration injury

Cited by 94 publications

References 34 publications

Liquid ventilation

Liquid ventilation

Partial Liquid Ventilation in the Extremely Preterm Infant: Potential Benefits and Harms

Comparison of perfluorochemical fluids used for liquid ventilation: Effect of endotracheal tube flow resistance

Contact Info

Product

Resources

About