Liquid biopsy in the setting of leptomeningeal metastases: a systematic review and meta-analysis

Wijaya, Jeremiah H.; Patel, Utsav D.; Quintero-Consuegra, Miguel D.; Aguilera-Peña, Maria P.; Madriñán-Navia, Humberto J.; Putra, Aulia W.; July, Julius; Kataria, Saurabh

doi:10.1007/s11060-023-04519-9

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…The inclusion of liquid biopsy (derived from either blood or CSF) in the diagnostic process is essential for early detection of LM. Wijaya et al (1) systematically examined the diagnostic efficacy of circulating tumor DNA (ctDNA) obtained from CSF in comparison to plasma ctDNA in LM patients. Their findings affirm that liquid biopsies possess superior diagnostic efficacy for detecting genomic alterations when utilizing CSF-derived samples compared to plasma.…”

Section: Editorial On the Research Topic Improving Clinical Practice ...mentioning

confidence: 99%

Editorial: Improving clinical practice for the diagnosis and management of patients with leptomeningeal metastasis

La Rocca,

Mazzucchi,

Altieri

et al. 2024

Front. Neurol.

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Section: Editorial On the Research Topic Improving Clinical Practice ...mentioning

confidence: 99%

Editorial: Improving clinical practice for the diagnosis and management of patients with leptomeningeal metastasis

La Rocca,

Mazzucchi,

Altieri

et al. 2024

Front. Neurol.

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The early recognition and diagnosis of neoplastic meningitis

Pellerino,

Bertero,

Pronello

et al. 2023

Expert Review of Neurotherapeutics

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Survival and treatment outcomes in patients with leptomeningeal disease from metastatic melanoma

Saberian,

Milton,

Simon

et al. 2024

Neuro-Oncology Practice

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Background Melanoma leptomeningeal disease (LMD) has poor prognosis. However, the management of patients with advanced melanoma has evolved with time, including those with LMD. We reviewed a large cohort of melanoma LMD patients to assess factors associated with survival. METHODS Retrospective clinical data was collected on patients diagnosed with LMD at MD Anderson Cancer Center from 2015-2020. Overall survival (OS) was determined from LMD diagnosis to date of death or last follow-up. The Kaplan-Meier method and log-rank test were used to estimate OS and to assess univariate group differences, respectively. Multivariable associations of survival with variables of interest were determined using Cox proportional hazards regression models. RESULTS 172 patients were identified. The median age at LMD diagnosis was 53 (range 20-79) years, and all patients had radiographic evidence of LMD on MRI of either brain or spine. 143 patients previously received systemic therapy (83%), with a median of two prior treatments (range 0-5). 81 patients (47%) had concurrent uncontrolled systemic disease and 80 patients (53%) had elevated serum LDH at the time of diagnosis. With a median follow-up of 4.0 months (range 0.1-65.3 months), median OS for all patients from LMD diagnosis was 4.9 months. Patients (n=45) who received intrathecal (IT) therapy or systemic immunotherapy for LMD had a median OS of 8.0 months and 10.2 months, respectively. On multivariable analysis, decreased performance status, positive CSF cytology, elevated LDH, and whole brain radiation were associated with worse OS. CONCLUSIONS Despite many advances in therapeutic options, the outcomes of melanoma patients with LMD remains poor. However, a subset of patients appears to derive benefit from LMD-directed treatment.

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Liquid biopsy in the setting of leptomeningeal metastases: a systematic review and meta-analysis

Cited by 4 publications

References 23 publications

Editorial: Improving clinical practice for the diagnosis and management of patients with leptomeningeal metastasis

Editorial: Improving clinical practice for the diagnosis and management of patients with leptomeningeal metastasis

The early recognition and diagnosis of neoplastic meningitis

Survival and treatment outcomes in patients with leptomeningeal disease from metastatic melanoma

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