Liquid chromatographic determination including simultaneous “on-cartridge” separation of ranitidine cisapride drug combinations from paediatric plasma samples using an automated solid-phase extraction procedure

A single LC–tandem mass spectrometry method for the simultaneous determination of four H2 antagonists in human plasma

“…A number of analytical methods have been reported for the determination of individual H 2 antagonists in human plasma since 1990 years, cimetidine [1][2][3][4][5][6][7][8], ranitidine [9][10][11][12][13][14][15][16][17], famotidine [18][19][20][21][22][23][24][25], and lafutidine [26][27][28][29]. Apart from some uncommonly used methods such as free capillary zone electrophoresis [4], micellar electrokinetic capillary chromatography [7], HPTLC [13], most reports utilized HPLC-UV method [1][2][3][4][5][6][7][9][10][11][12][13][14][15][16][18][19]…”

“…Apart from some uncommonly used methods such as free capillary zone electrophoresis [4], micellar electrokinetic capillary chromatography [7], HPTLC [13], most reports utilized HPLC-UV method [1][2][3][4][5][6][7][9][10][11][12][13][14][15][16][18][19][20][21][22][23]26,27]. Although HPLC method is mature and relatively economical, limitations such as sensitivity, selectivity and throughput were often encountered during the method development.…”

Spectrophotometric Method for Ranitidine Determination in Drugs Using Rhodamine B

“…In order to assure the quality of R . HCl containing pharmaceutical formulations, several methods have been developed for its determination, including high-performance liquid chromatography (HPLC) [1][2][3][4][5][6] , high-performance thin-layer chromatography and scanning densitometry 7 , differential pulse polarography 8 , amperometry 9 , capillary electrophoresis 10 , conductometry 11 , coulometry 12 , voltammetry 13 , potentiometry 14 , fluorimetry 15 , chemiluminescence 16 , AAS 17 . The official method described in the United States Pharmacopeia 18 is based on potentiometric titration of R .…”

Determination of ranitidine in urine by capillary electrophoresis-electrochemiluminescent detection

“…So, it is possible to determine the quantity of ranitidine in urine as well as to learn a patient's treatment history. Primary work indicated that if urine sample was directly injected into the capillary, proteins and other biomolecules present in the urine matrix could be adsorbed to the wall of the capillary [4] and could influence the separation of the drug. Thus, a pretreatment procedure was necessary to remove the large amounts of interferential compounds [17].…”

“…Due to its critical role in the pharmaceutical industry, it is important to determine ranitidine in biological fluids. Among the analytical techniques, polarography [2], high-performance liquid chromatography (HPLC) [1,[3][4][5][6][7][8], thin layer chromatography (TLC) [9] and supercritical fluid chromatography [10] have been used for the determination of ranitidine. Although TLC method could simultaneously determine several samples and the standard solution, the plate coating, chamber saturation with mobile phase, and spotting were time-consuming and cost effective.…”