Liquid Chromatographic Determination of Deoxynivalenol in Baby Food and Animal Feed: Interlaboratory Study

Stroka, J; Derbyshire, Michelle; Carsten, Mischke; Massimo, Ambrosio; Katy, Kroeger; Arranz, Isabel; Sizoo, E. A.; H, van Egmond

doi:10.1093/jaoac/89.4.1012

Cited by 12 publications

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“…Using this approach nivalenol has been determined (together with deoxynivalenol) at levels down to 50 µg/kg in cereals. The major drawback of HPLC-UV detection is the high background noise caused by co-extracted compounds (MacDonald et al, 2005;Stroka et al, 2006). FLD detection generally leads to lower detectability and selectivity of the measurement compared to HPLC-UV.…”

Section: Chromatographic Methodsmentioning

confidence: 99%

Scientific Opinion on risks for animal and public health related to the presence of nivalenol in food and feed

2013

EFSA Journal

136

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Nivalenol is a mycotoxin produced by various Fusarium species. The European Commission (EC) asked the European Food Safety Authority (EFSA) for a scientific opinion on the risk to human and animal health related to the presence of nivalenol in food and feed. A total of 13 164 results for nivalenol in food, feed and unprocessed grains, collected in 2001-2011 from 18 European countries, were available for the evaluation. The highest mean concentrations for nivalenol were observed in oats, maize, barley and wheat and products thereof. Grains and grain-based foods, in particular bread and rolls, grain milling products, pasta, fine bakery wares and breakfast cereals, made the largest contribution to nivalenol exposure for humans. Animal exposure to nivalenol is primarily from consuming cereal grains and cereal by-products. The available information on the toxicokinetics of nivalenol is incomplete. Evidence exists for metabolic de-epoxidation in some species. Based on the data available, the Panel on Contaminants in the Food Chain (CONTAM Panel) concluded that the overall weight of evidence is that nivalenol is unlikely to be genotoxic. Toxic effects of nivalenol include immunotoxicity and haematotoxicity. A reduction in white blood cell (WBC) counts in a 90-day rat study was identified as the critical effect for human risk assessment. Using these data and a benchmark dose analysis the CONTAM Panel established a tolerable daily intake (TDI) of 1.2 µg/kg b.w. per day. All chronic human dietary exposures to nivalenol estimated, based on the available occurrence data in food, are below the TDI, and are therefore not a health concern. No toxicity data were identified for ruminants, rabbits, fish and companion animals but lowest-observed-adverse-effect levels were identified in pigs and poultry. Based on estimates of exposure the risk of adverse health effects of feed containing nivalenol is low for both these species

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Section: Chromatographic Methodsmentioning

confidence: 99%

Scientific Opinion on risks for animal and public health related to the presence of nivalenol in food and feed

2013

EFSA Journal

136

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“…MacDonald et al, 2005;Stroka et al, 2006). The established HPLC methods were assessed for linearity, recovery, precision, limit of detection and limit of quantification (ICH, 2005).…”

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confidence: 99%

The fate of deoxynivalenol and its derivatives in spring wheat whole-grain flour during storage

Janavičienė

Mankevičienè

Kochiieru

2020

Zemdirbyste-Agriculture

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A study was conducted at Institute of Agriculture, Lithuanian Research Centre for Agriculture and Forestry to explore the quantitative changes in type B trichothecenes: deoxynivalenol (DON), 3-acelyt-deoxynivalenl (3-ADON) and 15-acetyl-deoxynivalenol (15-ADON), in spring wheat whole-grain flour as influenced by storage period and temperature. Samples with different concentrations of DON and its metabolites were selected and stored in two controlled climate chambers at different temperatures (18°C and 28°C) at the same ambient air humidity (~80%). The initial concentration ranged from 1246 to 4581 µg kg-1 for DON, from 440 to 820 µg kg-1 for 3-ADON and from 88 to 141 µg kg-1 for 15-ADON. The samples were analysed before the storage experiment and then after 4 and 8 weeks of storage. The findings of the DON retention showed no significant differences between the storage periods and temperatures; however, it was found that over time the concentrations of DON in the samples decreased. There were found significant differences (P < 0.05) in 3-ADON concentrations between storage periods and temperatures. Over time, 3-ADON concentrations decreased in the samples. Statistically significant increases in 15-ADON concentrations were identified over this period. Within 60 days of storage, the concentrations of DON decreased by 16% and 33%, 3-ADON-by 60% and 100%, and those of 15-ADON increased by 63% and 96% compared to the initial levels, depending on the combination of the experimental factors. The results of this study led to the conclusion that storage of spring wheat flour for several months at 80% relative humidity, at 18°C and 28°C temperatures did not have significant influence on the retention level of DON. However, the levels of DON derivative 3-ADON significantly decreased and the concentrations of 15-ADON significantly (almost twice) increased during flour storage and aging.

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Fusarium Mycotoxins. An Overview of Chemical Characterization and Techniques for its Determination from Agricultural Products

Astoreca

Magliano

Ortega

2013

Fusarium Head Blight in Latin America

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Liquid Chromatographic Determination of Deoxynivalenol in Baby Food and Animal Feed: Interlaboratory Study

Cited by 12 publications

References 0 publications

Scientific Opinion on risks for animal and public health related to the presence of nivalenol in food and feed

Scientific Opinion on risks for animal and public health related to the presence of nivalenol in food and feed

The fate of deoxynivalenol and its derivatives in spring wheat whole-grain flour during storage

Fusarium Mycotoxins. An Overview of Chemical Characterization and Techniques for its Determination from Agricultural Products

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