Liquid chromatographic determination of gemfibrozil and its metabolite in plasma

Randinitis, Edward J.; Parker, T.D.; Kinkel, Arlyn W.

doi:10.1016/s0378-4347(00)83493-3

Cited by 21 publications

(15 citation statements)

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“…Similar to AMG 853, a primary metabolic pathway of the peroxisome proliferator-activated receptor ␣-activating drug gemfibrozil is glucuronidation of its carboxylic acid moiety, which results in formation of an acyl glucuronide metabolite (Okerholm et al, 1976;Randinitis et al, 1984Randinitis et al, , 1986. Subsequent studies have identified gemfibrozil 1-O-acyl glucuronide as both a competitive inhibitor and a hememodifying ligand of CYP2C8 in vitro (Ogilvie et al, 2006;Baer et al, 2009;Jenkins et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Predicting the Drug Interaction Potential of AMG 853, a Dual Antagonist of the D-Prostanoid and Chemoattractant Receptor-Homologous Molecule Expressed on T Helper 2 Cells Receptors

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Predicting the Drug Interaction Potential of AMG 853, a Dual Antagonist of the D-Prostanoid and Chemoattractant Receptor-Homologous Molecule Expressed on T Helper 2 Cells Receptors

et al. 2012

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“…The mechanism of this action is not completely understood but may involve inhibition of peripheral lipolysis; reduced hepatic extraction of free fatty acids, which reduces hepatic triglyceride production; inhibition of synthesis and increased clearance of VLDL carrier, apolipoprotein B, which also reduces VLDL production and according to animal studies, reduced incorporation of longchain fatty acids into newly formed triglycerides, accelerated turnover and removal of cholesterol from the liver (stimulates incorporation of cholesterol precursors into precursors into liver sterols), and increased excretion of cholesterol in the feces [4][5][6][7][8][9] . Gemfibrozil is determined by high performance liquid chromatography (HPLC) [10][11][12][13] , liquid chromatography (LC) 14,15 , gas chromatography (GC) 16 19 , ion exchange 20 , hydrophobicity interaction 21 , and electrostatic interaction [22][23] . To our best knowledge, there are no reports for quantitative determination of gemfibrozil by using poly (gabapentin) film modified glassy carbon electrode.…”

Section: Introductionmentioning

confidence: 99%

Cyclic Voltammetric Studies of Gemfibrozil at Poly (Gabapentin) Film Modified Glassy Carbon Electrode

P¹,

Deepa²,

Naik³

et al. 2012

Int J Pharmceut Chem

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ABSTRACT:A polymerized film of gabapentin was prepared on the surface of a glassy carbon electrode (GCE) in phosphate buffer solution by electropolymerisation method using cyclic voltammetric technique. The poly (gabapentin) film modified glassy carbon electrode was calibrated with standard potassium ferrocyanide solution in 1 M KCl as a supporting electrolyte. This modified electrode used to study the electrochemical behavior of gemfibrozil, a lipid lowering drug in aqueous alcohol medium by cyclic voltammetric technique. It was found that the oxidation peak current of gemfibrozil at the modified GCE was greatly improved compared with that at the bare GCE. The effects of scan rate, pH, supporting electrolyte concentration, % of solvent and concentration of gemfibrozil were examined. With high sensitivity and selectivity, micro molar detection limit, high reproducibility together with ease of preparation and regeneration of the electrode surface make the electrode very stable for the determination of gemfibrozil in pharmaceutical and clinical preparations.

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“…Several reports on gemfibrozil determination have appeared in the literature. Gas chromatography [11] and high performance liquid chromatography (HPLC) with ultraviolet or fluorimetric detection [12][13][14][15][16][17][18][19] have been used for the determination of gemfibrozil and its metabolites in plasma and urine samples. A liquid chromatography-mass spectrometric method [20] has been reported for the determination of this drug in water and wastewater samples.…”

Section: Introductionmentioning

confidence: 99%

Development of a new analytical spectroscopic methodology based on the competitive aggregation in a dye–surfactant–drug system: Application to the determination of gemfibrozil

2008

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Abstract.A new analytical methodology based on the competitive aggregation in a dye-surfactant-drug system is developed for the determination of gemfibrozil. Eriochrome Blue Black R (EBBR) and Didodecyldimethylammonium bromide (DDABr) were the dye and surfactant used, respectively. In the proposed method, the anions of the dye bind to the cationic surfactant molecules to form dye-surfactant aggregates, which are monitored from changes in UV-Vis absorption features of the dye. In the ternary EBBR-DDABr-drug mixtures, the drug competes with the dye to interact with the surfactant, which results in a decrease in dye-surfactant aggregates formation. This, again, causes a change in absorption properties of the dye. The measurement parameter is the difference between the absorption of the dye in the presence and absence of the drug. In the appropriate experimental conditions the absorbance differences are directly proportional to the drug concentration. The influence of several experimental variables such as pH, concentrations of buffer, EBBR and DDABr on the measurement parameter were studied. Under the optimum conditions, the calibration graph was linear up to 6.0 µg ml −1 with the correlation coefficient of 0.998.The limit of detection and quantification were found to be 0.044 and 0.15 µg ml −1 , respectively. The method was validated and applied to the determination of gemfibrozil in pharmaceutical preparations.

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Liquid chromatographic determination of gemfibrozil and its metabolite in plasma

Cited by 21 publications

References 1 publication

Predicting the Drug Interaction Potential of AMG 853, a Dual Antagonist of the D-Prostanoid and Chemoattractant Receptor-Homologous Molecule Expressed on T Helper 2 Cells Receptors

Predicting the Drug Interaction Potential of AMG 853, a Dual Antagonist of the D-Prostanoid and Chemoattractant Receptor-Homologous Molecule Expressed on T Helper 2 Cells Receptors

Cyclic Voltammetric Studies of Gemfibrozil at Poly (Gabapentin) Film Modified Glassy Carbon Electrode

Development of a new analytical spectroscopic methodology based on the competitive aggregation in a dye–surfactant–drug system: Application to the determination of gemfibrozil

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