Liquid Chromatographic Determination of NSAIDs in Urine After Dispersive Liquid–Liquid Microextraction Based on Solidification of Floating Organic Droplets

Peer Review #2 of "Fabrication of calixarene-grafted bio-polymeric magnetic composites for magnetic solid phase extraction of non-steroidal anti-inflammatory drugs in water samples (v0.1)"

“…The maximum peak area was observed with 1.5 mL volume of acetonitrile. In contrast, above 1.5 mL of acetonitrile, the peak area decreased due to dilution factor and loss of analytes to environment at higher volume of organic eluent (Shukri et al, 2015;Hu et al, 2017;Rashidi Nodeh et al, 2017). During drying the elution extract by nitrogen gas stream, the higher volume needed more time to dry and preconcentrate the analytes.…”

“…Manuscript to be reviewed failure and stomach bleeding which can ultimately lead to sudden death. These side effects are more prominent towards those with poor health conditions and alcoholics (Shukri et al, 2015). The NSAIDs may transfer to natural streams through hospital and pharmaceutical units effluent, as well as private household manure (Toledo-Neira & Álvarez-Lueje, 2015).…”

“…Various sample preparation methods have been reported for the enrichment and purification of pharmaceutical compounds. Liquid-liquid extraction (LLE) (Wen, Tu & Lee, 2004;Payán et al, 2009), solid phase extraction (SPE) (Santos et al, 2005;Rodil et al, 2009), stir rod sorptive extraction (SRSE) (Luo et al, 2011), dispersive liquid-liquid microextraction (DLLME) (Shukri et al, 2015), and solid phase micro-extraction (SPME) (Moeder et al, 2000;Torres Padrón, Sosa Ferrera & Santana Rodríguez, 2009) methods are commonly used for determination of drugs and their metabolites. Among these techniques, solid phase extraction is one of the most virtual and reliable method due to its advantages of producing PeerJ reviewing PDF | (2018:02:25988:1:1:CHECK 1 Jun 2018)…”

Rapid ultrasound‐assisted dispersive solid‐phase extraction of nonsteroidal anti‐inflammatory drugs in urine using oleic acid functionalized magnetic graphene oxide

“…To assess the interday RSD%, the spiked samples at the same concentration were analyzed during three consecutive days. PF and AR% were calculated according to equations (4) and (5). Direct calibration is a curve that is plotted by analytical signals versus standard solutions with different concentrations.…”

Biocoacervation extraction combined with dispersive solid phase extraction using a reversed-phase core–shell magnetic molecularly imprinted sorbent for 2,4-dichlorophenoxyacetic acid prior to its determination by HPLC

“…They have as disadvantages to be laborious, to require a large sample volume and to be time consuming. An additional disadvantage of the traditional extraction method (LLE) is the use of significant amount of volatile and toxic organic solvents [6,7]. In order to reduce the detection limit and increased enrichment factor, the combination of different sample preparation methods has been more attention in recent years [8][9][10][11].…”