Liquid chromatographic separation of the enantiomers of trans-chlordane, cis-chlordane, heptachlor, heptachlor epoxide and α-hexachlorocyclohexane with application to small-scale preparative separation

Enantiomeric separation of chiral pesticides by high performance liquid chromatography on cellulose tris‐3,5‐dimethyl carbamate stationary phase under reversed phase conditions

“…Owing to the enantioselective interaction with enzymes, cellular receptors, or other chiral biological molecules [1], many enantiomers of pharmaceutical compounds may display quite different activities in biological systems. About one quarter of all agrochemical compounds used commercially are chiral and account for 26% of the total value of the world agrochemical market [2], and most of these agrochemical compounds are still sold in the form of racemates.…”

The chiral resolution of pesticides on amylose‐tris(3,5‐dimethylphenylcarbamate) CSP by HPLC and the enantiomeric identification by circular dichroism

“…The literature shows it could separate the enantiomers of fenamiphos, fensulfothion, profenofos, crufomate, 10 o,p-DDT, o,p-DDD, 11 and heptachlor epoxide. 12 The development of analytical methods for the efficient resolution of enantiomers is one of the most important tasks in the field of pesticides. A systematic study of the enantioselective HPLC chromatographic separation of the seven chiral pesticides on ADMPC CSP was carried out here with the aim of setting up methods for chiral analysis of single enantiomers.…”

Chirality as an Environmental Forensics Tool

“…No evidence of stereoselectivity was observed for degradation of PCBs 45,88,91,95,136,144, and 149 by the soil bacterium Jonibacter sp. strain MS3-02 [164].…”

“…Enantioselective HPLC has been less popular for enantiomer resolution of chiral POPs, given its lower chromatographic resolution compared to GC, but has been used for quantification purposes [83,84]. More commonly, HPLC has been used to purify POP enantiomers to simplify subsequent analysis by GC [85][86][87]; to collect sufficientmaterial [88] to determine chemical properties such as (þ) or (À) rotational designation and chromatographic elution order [20,39,57,[89][90][91][92][93], absolute configuration by vibrational circular dichroism [94,95], and chemical stability [96]; to characterize enantiomer-specific environmental fate and toxicity studies [19,20,97]; and to analyze POPs that are not thermally stable and cannot be measured by GC, such as HBCDDs [58,98,99]. Enantioselective CE, while a highly efficient analytical separations technique with up to a million theoretical plates, has not been used much for environmental analysis to date.…”