Liquid chromatography determination of residue levels on apples treated with cetylpyridinium chloride

Identification of potential antimicrobials against Salmonella typhimurium and Listeria monocytogenes using Quantitative Structure-Activity Relation modeling

“…Although CPC has long been held to be a “gold standard” for disinfectant antimicrobial compounds, there are many issues associated with the use of CPC as a food disinfectant. Studies have shown a rising trend of resistance to certain QACs (including CPC) among bacteria[ 20 ], a negative environmental impact of CPC runoff [ 21 ], and negative health effects from ingested QAC residue left on fatty surfaces [ 22 – 26 ]. There is a growing need to identify new antimicrobial QACs and similar compounds that share or mimic the general antimicrobial mechanisms.…”

Quantitative Structure-Activity Relation Study of Quaternary Ammonium Compounds in Pathogen Control: Computational Methods for the Discovery of Food Antimicrobials

“…CPC is an environmental hazard and leaves a toxic residue on surfaces [13,19]. This residue is dissolved and subsequently removed using propylene glycol (PEG) as a cosolvent with water.…”

“…This study focuses on the use of cetylpyridinium chloride (CPC) for decontamination. CPC is an effective antimicrobial, it has been approved only for use on raw chicken, although it has also shown effectiveness for use on beef and produce for both disinfection and the extension of shelf life [11][12][13]. CPC is classified as a quaternary ammonium compound (QAC), which is defined by its cationic nitrogen head.…”