Liquid chromatography/electrochemical detection of carbohydrates at a cobalt phthalocyanine containing chemically modified electrode

Santos, Leonel M.; Baldwin, Richard P.

doi:10.1021/ac00141a006

Cited by 191 publications

(66 citation statements)

References 42 publications

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“…CoPC modified electrodes show effective oxidation of some small [60][61][62] and larger molecular compounds [63][64][65], which normally exhibit a sluggish reaction at carbon electrodes. As shown in Fig.…”

Section: Copc Modified CCCmentioning

confidence: 99%

Electrochemical characteristics of conductive carbon cement as matrix for chemically modified electrodes

Huang

Pot

Kok

1995

Analytica Chimica Acta

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Electrochemical characteristics of conductive carbon cement as matrix for chemically modified electrodes Huang, X.; Pot, J.J.; Kok, W.T. General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. AbstractConductive carbon cement (CCC) was evaluated as matrix material for the preparation of electrodes bulk-modified with electrocatalysts. For pure CCC electrodes the background current characteristics were examined. In acidic or neutral phosphate buffers the useful electrode potential range was from -0.3 to + 1.0 V vs. SCE, while in 0.1 mol l-' NaOH it was from -0.3 to + 0.7 V. The electrochemical reversibility of CCC electrodes was examined by measuring the standard rate constants for the reduction of hexacyanoferrate( III) and the oxidation of hydroquinone, using cyclic voltammetry (CV) and rotating disk experiments. The reversibility of a CCC electrode was comparable with that of a freshly polished glassy carbon electrode and better than that of carbon paste electrodes. CCC was used as matrix for the preparation of electrodes bulk-modified with cuprous oxide and cobalt phthalocyanine (CoPC). With a C&O-CCC electrode the oxidation potential of glucose, which shows sluggish kinetics at unmodified carbon electrodes, was strongly reduced. The kinetics of the mediated glucose oxidation has been studied with a rotating disk electrode. It was shown that at glucose concentrations higher than approximately 1 mmol 1-l the electrochemical regeneration of the catalyst becomes rate-determining. The Cu@-CCC modified electrode has been applied with a constant potential in flow-injection analysis for the determination of glucose. The long-term stability of the electrode was studied; repeated injections of a glucose solution during a period of 6 h yielded a relative standard deviation of the peak height of 1.8% (n = 57). In CV experiments the electrocatalytic activity of CoPC was shown for the oxidation of various compounds such as penicillamine, hydrazine and bile acids. Application of the CoPC-CCC electrode for the detection of bile acids in flow-through detection with a constant or pulsed potential failed, due to a rapid deactivation of the electrode.

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Section: Copc Modified CCCmentioning

confidence: 99%

Electrochemical characteristics of conductive carbon cement as matrix for chemically modified electrodes

Huang

Pot

Kok

1995

Analytica Chimica Acta

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“…All derivatives were substituted with three α-mannose units on each porphyrin in the hope of targeting tumor cells which contained over-expressed lectin-type membrane receptors. The four oligomers (418)(419)(420)(421) were all synthesized from a single parent monomer 417 with varying π-conjugation linkers between the porphyrin moieties. The parent monomer 417 was pre-formed in five steps and the trimethylsilyl group was deprotected for oligomer synthesis.…”

Section: Glycosidation Reactions O-linked Systemsmentioning

confidence: 99%

“…Certain types of Rh porphyrins were found to be good catalysts for oxidizing aldose in low-potential regions and exhibited higher activity for aldose than ketose derivatives. Also investigated for such application were cobalt phthalcyanines [420][421][422][423][424] .…”

Section: Catalysismentioning

confidence: 99%

Chemical Synthesis and Medicinal Applications of Glycoporphyrins

Moylan¹,

Scanlan²,

Senge

2015

CMC

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Abstract:This review presents an in-depth overview of the modification of porphyrins with bioconjugates and their applications in medicine today. Porphyrin bioconjugates ranging from nucleotides to steroids are under active scrutiny. However, carbohydrates have been at the forefront of such research in recent years and offer significant potential. This is attributed to their own selectivity to lectins on the surface of cancer cells and their influence on the amphiphilicity of the porphyrin macrocycle. These characteristics and the tendency of porphyrin photosensitizers to accumulate in tumor tissues make glycoporphyrins promising candidates for use as photosensitizers. Thus, a detailed overview of the synthesis and biological evaluation of glycoporphyrins is given with a particular focus on their applications in photodynamic therapy and their future prospects as drug candidates have been reported.

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“…The other is the constant potential amperometry in which transition metals (Cu, Ni), [12][13][14][15][16][17][18] Ni alloys [19][20][21][22][23] or chemically modified electrodes based on the transition metals [24][25][26] are used as working electrodes. The constant potential amperometry employs simpler instrumentation and provides higher sensitivity compared to PAD.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Platinum Electrodes for Amperometric Determination of Sugars with Anion Exchange Chromatography

et al. 2010

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A simple amperometric detection (AD) method based on mesoporous platinum (Pt) electrodes has been developed for the determination of sugars (glucose, fructose, and sucrose) with high-performance anion-exchange chromatography (HPAEC). The amperometric detection is based on the direct oxidation of sugars on mesoporous Pt films formed on a gold electrode. The mesoporous Pt electrode (roughness factor of 243) sensitively responded to glucose, fructose, and sucrose in 80 mM sodium hydroxide solution as an alkaline mobile-phase for HPAEC. Under the optimum conditions, the limits of detection (S/N = 3) in these sugars were 0.24, 0.29, and 1.8 mM, for glucose, fructose, and sucrose, respectively. The reproducibility (relative standard deviation) of the measurements was less than 3.5%. The present method was applied to the determination of sugars in apple juice. The recoveries for all sugars ranged from 97 to 99%.

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Liquid chromatography/electrochemical detection of carbohydrates at a cobalt phthalocyanine containing chemically modified electrode

Cited by 191 publications

References 42 publications

Electrochemical characteristics of conductive carbon cement as matrix for chemically modified electrodes

Electrochemical characteristics of conductive carbon cement as matrix for chemically modified electrodes

Chemical Synthesis and Medicinal Applications of Glycoporphyrins

Mesoporous Platinum Electrodes for Amperometric Determination of Sugars with Anion Exchange Chromatography

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