Liquid chromatography of cephalosporin C on substituted polystyrene resins

Sacco, D.; Dellacherie, Édith

doi:10.1021/ac00272a071

Cited by 14 publications

(2 citation statements)

References 15 publications

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“…Polystyrene (PS) is an amorphous and glassy polymer with highly ordered structures solely constructed by the polymerization of styrene. Owing to its strong covalent linkages between light elements (H and C), PS possesses many unique features such as low density, ease of handling, negligible solubility in water, nonbiodegradability, and nontoxicity, which make it applicable to diverse fields including wastewater treatment, − chromatographic separation, − solid-phase extraction, − and adsorption of proteins/peptides. − …”

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Sub-ppt Mass Spectrometric Detection of Therapeutic Drugs in Complex Biological Matrixes Using Polystyrene-Microsphere-Coated Paper Spray

et al. 2017

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Polystyrene (PS) is a class of polymer materials that offers great potential for various applications. However, the applications of PS microspheres in paper spray mass spectrometry are largely underexplored. Herein we prepared a series of PS microspheres via a simple dispersion polymerization and then used them as coating materials for paper spray mass spectrometry (MS) in high-sensitivity analysis of various therapeutic drugs in complex biological matrixes. In the preparation of PS-coated papers, the coating method was found playing a key role in determining the performance of the resulting paper substrate in addition to other parameters (e.g., starch type and amount, PS coating amount, and spray solvent). We also found that as a solvent was applied on PS-coated paper for paper spray, the analytes of interest would be first extracted out and then moved to the tip of paper triangle for spray along with the applied solvent. In the process, the surface energy of PS particles had a strong impact on the desorption performance of analytes from PS-coated paper substrate, and the PS with a high surface energy favored the elution of analytes to allow a high MS sensitivity. When the prepared PS coated paper was used as a substrate for paper spray, it gave high sensitivity in analysis of therapeutic drugs in various biological matrixes such as whole blood, serum, and urine with excellent repeatability and reproducibility. In contrast to uncoated filter paper, an improvement of 10-546-fold in sensitivity was achieved using PS-coated paper for paper spray, and an estimated lower limit of quantitation (LLOQs) in the range of 0.004-0.084 ng mL was obtained. The present study is significant in exploring the potential of PS for high-sensitivity MS analysis, and it provides a promising platform in the translation of the MS technique to clinical applications.

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Sub-ppt Mass Spectrometric Detection of Therapeutic Drugs in Complex Biological Matrixes Using Polystyrene-Microsphere-Coated Paper Spray

et al. 2017

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“…For many years, micro-scale PS particles have found a wide variety of applications in many advanced materials and optical devices because of their homogeneous size, large surface area, negligible solubility in water, and invariant surface characteristics. [18][19][20][21] PS has also been extensively used as an adsorbent in the treatment of wastewater, [22][23][24][25][26] chromatographic separations, [27][28][29][30][31][32][33] solid-phase extraction, [34][35][36][37][38][39][40] and adsorption of proteins/peptides. [18][19][20][21][41][42][43][44][45] Although PS represents a powerful substrate that allows high efficiency treatment of various compounds in complex matrices, a complete analysis of its surface interactions is essential to further understand its performance and to develop improved materials.…”

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Abnormal adsorption and desorption behavior of pharmaceutical drugs on polystyrene microspheres

et al. 2017

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Equilibria for the adsorption of antibiotics onto neutral polymeric sorbents: Experimental and modeling studies

Chaubal

Payne

Reynolds

et al. 1995

Biotech & Bioengineering

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The objective of this work was to study the equilibria for adsorption of three antibiotics (penicillin V, tetracycline, and cephalosporin C) from water onto commercially available neutral polymeric sorbents. The pH was observed to be an important factor in adsorption as our results suggest that the neutral forms of penicillin V and cephalosporin C are preferentially adsorbed onto the neutral sorbents. Also, sorbent surface chemistry was observed to be important for adsorption, as the antibiotics adsorbed more favorably (both in terms of affinities and enthalpies) onto the aromatic sorbent as compared to the aliphatic ester sorbent. In addition to these thermodynamic measurements, molecular modeling studies and Monte Carlo simulations suggest that adsorption onto aromatic sorbents may involve specific interactions between the planar regions of the antibiotic molecules and the phenyl rings of the aromatic sorbent. The interaction energies predicted from Monte Carlo simulations were observed to provide qualitative agreement with experimentally determined adsorption affinities. (c) 1995 John Wiley & Sons, Inc.

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Liquid chromatography of cephalosporin C on substituted polystyrene resins

Cited by 14 publications

References 15 publications

Sub-ppt Mass Spectrometric Detection of Therapeutic Drugs in Complex Biological Matrixes Using Polystyrene-Microsphere-Coated Paper Spray

Sub-ppt Mass Spectrometric Detection of Therapeutic Drugs in Complex Biological Matrixes Using Polystyrene-Microsphere-Coated Paper Spray

Abnormal adsorption and desorption behavior of pharmaceutical drugs on polystyrene microspheres

Equilibria for the adsorption of antibiotics onto neutral polymeric sorbents: Experimental and modeling studies

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