Liquid crystalline drug delivery systems

Nalone, Luciana; Marques, Carlo Aldrovandi Torreão; Costa, Salvana Priscylla Manso; Souto, Eliana B.; Severino, Patrícia

doi:10.1016/b978-0-12-817870-6.00007-9

Cited by 5 publications

(8 citation statements)

References 41 publications

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“…All of the selected systems presented pseudoplasticity due to their organized mesophase which causes greater resistance to flow, and, with the exception of the 10ER system, all systems demonstrated a high degree of thixotropy [ 14 ]. Thus, systems with a higher degree of thixotropy also have a higher degree of initial organization, which is directly proportional to the area of hysteresis in the flow curve [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…For each diagram, 36 different formulations were prepared, with proportions varying from 10 to 80% ( w / w ) of the components mentioned above. After adding all the components, the formulations were homogenized with Ultra Turrax (IKA-T25 basic) at 13,000 RPM, for 3 min and then kept at rest for 24 h [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

“…The advent of systems such as liquid crystals has increased studies of other possible routes for the delivery of rifampicin for drug therapy, such as sublingual, nasal, and cutaneous administration [ 10 ]. Recent studies characterize liquid crystals and explore the possibility of their application through different routes for drug administration [ 11 , 12 , 13 , 14 ]. The naturally high viscosity of liquid crystals allows fixation of the formulation at a desired site of action after administration.…”

Section: Introductionmentioning

confidence: 99%

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Development of a Mucoadhesive Liquid Crystal System for the Administration of Rifampicin Applicable in Tuberculosis Therapy

Santos

Rodero

Ribeiro

et al. 2022

Life

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Since 1966, rifampicin (RIF) has been considered one of the most potent drugs in the treatment of tuberculosis (TB), which is caused by infection with M. tuberculosis (Mtb). New nanostructured formulations for RIF delivery and alternative routes of administration have been studied as potential forms of treatment. This study evaluates a liquid crystal system for RIF delivery, using alternative drug delivery routes. The systems developed are composed of surfactant, oleylamine, and soy phosphatidylcholine. With the aid of polarized light microscopy, it was possible to determine that the developed systems had a hexagonal mesophase. All systems developed showed non-Newtonian pseudoplasticity and a high degree of thixotropy. Liquid crystal systems with RIF showed an increase in elastic potential, indicating greater mu-coadhesiveness. The evaluation of mucoadhesive forces revealed an increase in the mucoadhesive potential in the presence of mucus, indicating the presence of satisfactory mucoadhesive forces. The 9DR and 10DR liquid crystal systems, when submitted to Differential Scanning Calorimetry analysis, remained structured even at temperatures above 100 °C, showing excellent stability. The developed liquid crystal systems showed a tolerable degree of cytotoxicity and bactericidal potential, for example, the 9DR system demonstrated a reduction in bacterial load after the third day and reached zero CFU on the seventh day of the test. The developed systems were also evaluated in the preclinical model of Mtb-infected mice, using the nasal, sublingual, and cutaneous route for the delivery of RIF associated with a nanostructured liquid crystal system as a possible tool in the treatment of TB.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of a Mucoadhesive Liquid Crystal System for the Administration of Rifampicin Applicable in Tuberculosis Therapy

Santos

Rodero

Ribeiro

et al. 2022

Life

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“…Furthermore, liquid crystals are easy to scale up, cheap, and thermodynamically stable. 77 However, the result of two studies applying MTX-loaded liquid crystalline system on psoriatic-induced animal models was disappointed. Their histopathological results after using these formulations in psoriatic-induced mouse model were not improved and inflammatory cytokine parameters after using these formulations were higher, comparing to the control.…”

Section: Resultsmentioning

confidence: 99%

The Anti-Psoriatic Efficacy and Safety Profile of Topical and Intralesional Methotrexate: A Literature Review

Chaiyabutr¹,

Punnakitikashem²,

Silpa‐archa³

et al. 2022

CCID

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Methotrexate (MTX) has long been considered the first-line oral systemic pharmacotherapy for psoriasis. The drug has several well-known systemic side effects, such as bone marrow suppression and hepatotoxicity. To avoid them, the use of topical or intralesional administrations of MTX has become an interesting option. With the advent of novel drug delivery systems, especially nanocarriers, the usage of a high-efficacy and safe topical MTX for psoriasis has nearly been attained. This review examined the development, anti-psoriatic efficacy and adverse effects of topical forms of MTX (plain MTX; MTX with chemical enhancer; MTX using nanotechnology; MTX with protein transduction domains; MTX with liquid crystalline systems; and MTX with physical enhancer/laser) and intralesional MTX in psoriasis patients and psoriasis-induced animals. The efficacy of topical MTX varied with the drug delivery technology employed. Nevertheless, the overall safety profile of the topical forms was favourable. A 25 mg/mL MTX solution injected intralesionally at the nail matrix worked well for nail psoriasis recalcitrant to topical treatment. To improve the standard of care for patients with psoriasis, randomized controlled trials that establish the most effective MTX-delivery system are needed.

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“…The lyotropic liquid phase (LCP) is a self-assembled system, commonly consisting of amphiphilic molecules (polar lipids and surfactants) and solvents. In the lyotropic phases, amphiphilic molecules are surrounded by solvent molecules to offer fluidity to the system [51]. The presence of solvent and water molecules modify the self-assembly of microstructures.…”

Section: Importance Of Lyotropic Liquid Crystalsmentioning

confidence: 99%