Liquid Gastric Emptying is Often Abnormal When Solid Emptying is Normal

Ziessman, Harvey A.; Okolo, Patrick I.; Mullin, Gerard E.; Chander, Ankit

doi:10.1097/mcg.0b013e318181b42f

Cited by 47 publications

(37 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fifty five of these 60 patients did not have diabetes and, hence, represent 16% (55/336) of all non-diabetics and 28% (55/197) of non-diabetic patients with normal solid GES. Zeissman et al has recently reported that assessment of gastric emptying of liquids alone without solid food may provide added information in patient assessment [12,13]. In his studies, in which the liquid GES and solid GES were performed separately but sequentially on the same day, 32% of patients with normal solid gastric emptying had delayed liquid emptying [13].…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Gastric Emptying of Solids and Liquids for Evaluation for Gastroparesis

et al. 2011

View full text Add to dashboard Cite

Gastric emptying of liquids correlates well with gastric emptying of solids. When evaluating patients for gastroparesis, assessment of gastric emptying of liquids in addition to solids may help identify additional patients with delayed gastric emptying, particularly non-diabetic patients where 26% with normal solid emptying may have delayed emptying of liquids. Symptoms of gastroparesis, however, are primarily associated with delayed gastric emptying of solids.

show abstract

Section: Discussionmentioning

confidence: 98%

“…Thus, assessment of gastric emptying of solids and liquids evaluate different aspects of gastric physiology. Recent studies using sequential liquid and solid gastric emptying have reported identification of patients with delayed liquid emptying but normal solid emptying [12,13].…”

Section: Introductionmentioning

confidence: 99%

Gastric Emptying of Solids and Liquids for Evaluation for Gastroparesis

et al. 2011

View full text Add to dashboard Cite

show abstract

“…In a retrospective analysis from one study, 13 of 17 patients with symptoms of gastroparesis had normal solid gastric emptying but showed delayed liquid gastric emptying. 100 In a prospective followup from the same study, 10 of 30 individuals with symptoms of gastroparesis and normal solid gastric emptying showed delayed liquid gastric emptying. In another study of 101 individuals with sus pected gastroparesis, delays in solid gastric emptying were found in 16% of individuals, whereas delayed liquid gastric emptying was detected in 32%.…”

Section: Diagnosis Of Presumed Gastroparesismentioning

confidence: 95%

Gastroparesis: pathogenesis, diagnosis and management

Hasler

2011

Nat Rev Gastroenterol Hepatol

103

110

View full text Add to dashboard Cite

Gastroparesis is a prevalent condition that produces symptoms of delayed gastric emptying in the absence of physical blockage. The most common etiologies of gastroparesis are idiopathic, diabetic, and postsurgical disease, although some cases stem from autoimmune, paraneoplastic, neurologic or other conditions. Histologic examination of gastric tissues from patients with severe gastroparesis reveals heterogeneous and inconsistent defects in the morphology of enteric neurons, smooth muscle and interstitial cells of Cajal, and increased levels of inflammatory cells. Diagnosis is most commonly made by gastric emptying scintigraphy; however, wireless motility capsules and nonradioactive isotope breath tests have also been validated. A range of treatments have been used for gastroparesis including dietary modifications and nutritional supplements, gastric motor stimulatory or antiemetic medications, endoscopic or surgical procedures, and psychological interventions. Most treatments have not been subjected to controlled testing in patients with gastroparesis. The natural history of this condition is poorly understood. Active ongoing research is providing important insights into the pathogenesis, diagnosis, treatment and outcomes of this disease.

show abstract

“…One method begins with a 30-min liquid-only study followed by the solid study (5,6). The other approach is to simultaneously administer the dual-isotope solid and liquid meal (7).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Radionuclide Esophagogastrointestinal Transit Study: Methodology, Reference Values, and Initial Clinical Experience

Antoniou¹,

Raja

El-Khouli³

et al. 2015

J Nucl Med

Self Cite

View full text Add to dashboard Cite

A radionuclide methodology and reference values have been developed for a single gastrointestinal transit study including esophageal transit, liquid and solid gastric emptying, and small-and largebowel transit, using 111 In-diethylenetriaminepentaacetic acid (DTPA) with the standardized 99m Tc-labeled solid meal. Methods: Eighteen healthy subjects and 18 patients were investigated. The esophageal transit study was performed with 3.7 MBq (0.1 mCi) of 111 In-DTPA in 15 mL of water. A liquid-only 30-min gastric-emptying study followed, with ingestion of 3.7 MBq (0.1 mCi) of 111 In-DTPA in 300 mL of water. Then, a simultaneous solid-liquid emptying study was acquired after ingestion of a solid 99m Tc-sulfur colloid-labeled meal and 7.4 MBq (0.2 mCi) of 111 In-DTPA in 120 mL of water. Images were acquired intermittently for 4 h. Additional 111 In images were acquired at 5 and 6 h to measure small-bowel transit, and at 24, 48, and 72 h for largebowel transit. Results: Reference values were determined for esophageal transit (transit time, percentage emptying at 10 s), liquid-only gastric emptying (emptying half-time), liquid and solid emptying in a dual-phase solid-liquid study (emptying half-time and percentage emptying at 1, 2, 3, and 4 h), small-bowel transit index (percentage transit to ileocecal valve at 6 h), and colonic transit (geometric center and percentage colonic emptying) at 24, 48, and 72 h. Results from the first 18 patients found abnormal transit in 72% (13/18); clinical management changed in 61% (11/18). Conclusion: We have developed a radionuclide methodology and derived reference values for a comprehensive gastrointestinal transit study using 111 In-DTPA with the standardized 99m Tc-labeled solid meal. Our initial clinical experience suggests clinical value.

show abstract

Liquid Gastric Emptying is Often Abnormal When Solid Emptying is Normal

Abstract: Liquid gastric emptying is commonly abnormal in patients who have normal solid studies. Liquid studies should be routinely performed in addition to solid studies to fully evaluate gastric motility in patients with symptoms suggestive of gastroparesis.

Cited by 47 publications

References 25 publications

Gastric Emptying of Solids and Liquids for Evaluation for Gastroparesis

Gastric Emptying of Solids and Liquids for Evaluation for Gastroparesis

Gastroparesis: pathogenesis, diagnosis and management

Comprehensive Radionuclide Esophagogastrointestinal Transit Study: Methodology, Reference Values, and Initial Clinical Experience

Contact Info

Product

Resources

About