Accelerator driven subcritical reactors have attracted much attention in recent years for their ability to generate energy and transform radioactive waste in a cleaner and safer manner. As an important part of accelerator driven subcritical system (ADS), control system is directly related to the stable and safe operation of the system. Therefore, it is necessary to build a high-precision control system simulation platform that is easy to design and verify. In this paper, a simulation platform coupling Simulink and Locust is developed for the control system design of ADS in China. Based on an explicit thermal coupling strategy (TCS) of interface heat flux and wall temperature, the entire closed-loop system model is established. The simulation platform is divided into two parts according to the coolant type: the first part with lead bismuth eutectic is composed of the shell side of the interface heat exchanger (IHX), reactor, and main pump; the second part with water include the tube side of IHX, air cooler, feedwater pump, and flow network. To verify the effectiveness of the TCS method, the thermohydraulics parameters of once-through steam generator (OTSG) calculated by the coupled model were compared with those calculated by single Locust model under steady and transient conditions.The results show that the two models have good consistency. The coupled platform is able to successfully simulate dynamic processes under different conditions. In addition, simulation verification is carried out under the step change of 10% FP to study its control characteristics. The results show that the control effect of the coupled platform is slightly better than that of single Locust.The control system has a good ability to adjust the ADS system, and extends the functions of traditional Locust without modifying the Locust source code. While ensuring the accuracy of the model, it increases the flexibility of modeling and improves the modeling efficiency, which can provide an important reference for further engineering applications.