2019
DOI: 10.1002/anie.201910986
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Liquid Metastable Precursors of Ibuprofen as Aqueous Nucleation Intermediates

Abstract: The nucleation mechanism of crystals of small organic molecules, postulated based on computer simulations, still lacks experimental evidence. In this study we designed an experimental approach to monitor the early stages of the crystallization of ibuprofen as a model system for small organic molecules. Ibuprofen undergoes liquid–liquid phase separation prior to nucleation. The binodal and spinodal limits of the corresponding liquid–liquid miscibility gap were analyzed and confirmed. An increase in viscosity su… Show more

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Cited by 61 publications
(79 citation statements)
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“…The multistep model, designated by nonclassical nucleation theory, accounts for the presence of intermediates in the pre-nucleation stage . Such intermediates have been illustrated in several materials systems including calcium-based inorganics [4][5][6][7][8] , organics [9][10][11] , polymers [12][13][14] , metals [15][16][17] , and semiconductor quantum dots (QDs) [18][19][20][21][22][23][24][25][26][27][28] .…”
mentioning
confidence: 99%
“…The multistep model, designated by nonclassical nucleation theory, accounts for the presence of intermediates in the pre-nucleation stage . Such intermediates have been illustrated in several materials systems including calcium-based inorganics [4][5][6][7][8] , organics [9][10][11] , polymers [12][13][14] , metals [15][16][17] , and semiconductor quantum dots (QDs) [18][19][20][21][22][23][24][25][26][27][28] .…”
mentioning
confidence: 99%
“…The advance in the synthesis of quantum dots, resulting in an in‐depth understanding of the induction period described by the two‐pathway model, facilitates the control of size and particle yield of quantum dots, and thus embraces the promise of colloidal semiconductor quantum dots in various application areas . Furthermore, this two‐pathway model reinforces the multistep nucleation model which has been proposed for several other material systems including organics, polymers, inorganics, and metals …”
Section: Introductionmentioning
confidence: 52%
“…Also, the present study provides a more complete understanding of the evolution of MSCs and the transformations among them . Similar to the fabrication of small‐size CdS quantum dots with enhanced particle yield from a CdS induction period sample, the room‐temperature synthesis of single‐ensemble CdTeSe MSC‐399 by mixing CdTe and CdSe induction period samples assists in the advance of nonclassical nucleation theory …”
Section: Introductionmentioning
confidence: 84%
“…FFA, where the molecules are in a higher concentration compared to the mother solution. As such, in the DLP the molecules are hindered in their translational and rotational movements and kinetically stable (metastable) whilst still possessing an interface with the surrounding liquid 9 .…”
Section: Resultsmentioning
confidence: 99%