Liquid Methionine Hydroxy Analog (Free Acid) and DL-Methionine Attenuate Calcium-Induced Kidney Damage in Domestic Fowl

Wideman, Robert F.; Ford, Bonnie C.; Leach, R. M.; Wise, Dirk F.; W, Robey

doi:10.3382/ps.0721245

Cited by 8 publications

(6 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Urinary uric acid excretion in birds with severe kidney damage caused by the HC and HCHP diets was not significantly less than in the control, suggesting that increased plasma uric acid is not the result of decreased urinary uric acid excretion. Our results also supported a previous study showing that plasma uric acid concentrations are not directly related to calcium-induced kidney damage (Wideman et al, 1993). Other factors such as the higher protein ingested in HCHP may have increased plasma uric acid.…”

Section: Discussionsupporting

confidence: 93%

Clinicopathology of gout in growing layers induced by high calcium and high protein diets

Guo

Huang

Tang

2005

British Poultry Science

View full text Add to dashboard Cite

1. An experiment was conducted to test the independent and combined effects of high dietary calcium and protein concentrations on the induction of visceral gout in growing birds of a layer strain. 2. One hundred and sixty healthy birds were randomly divided into 4 groups at 35 d of age. The different groups were given 4 diets containing normal or high concentrations of dietary calcium or crude protein in a 2 x 2 factorial experiment for 30 d. The diets contained normal calcium (Ca) and crude protein (CP) (NCNP, 8.5 g Ca/kg and 175g CP/kg), high calcium and normal protein (HC, 36.3 g Ca/kg and 175 g CP/kg), normal calcium and high protein (HP, 8.8 g Ca/kg and 245 g CP/kg) or high calcium and high protein (HCHP, 36.8 g Ca/kg and 242 g CP/kg), respectively. 3. Typical visceral gout was induced by the HCHP diet. The HCHP and HC diet caused severe kidney damage. The HP diet did not cause kidney damage, but significantly increased plasma uric acid and inorganic phosphorus concentrations. 4. The HC diet significantly increased plasma uric acid, calcium and sodium, but significantly decreased plasma inorganic phosphorus, potassium and magnesium concentrations. The HCHP diet significantly increased plasma uric acid, calcium and sodium. 5. Urine volumes were significantly higher on the HCHP and HC diets than on the control. The growers raised on HC and HCHP diets had significantly higher total quantity of 24 h urinary excretion of uric acid, calcium, magnesium, inorganic phosphorus and potassium and a significantly lower 24 h urinary excretion of sodium. The growers fed on the HP diet had a higher 24 h urinary excretion of uric acid and inorganic phosphorus than the control. 6. It is concluded that growing layer birds should not be fed on layer rations.

show abstract

Section: Discussionsupporting

confidence: 93%

Clinicopathology of gout in growing layers induced by high calcium and high protein diets

Guo

Huang

Tang

2005

British Poultry Science

View full text Add to dashboard Cite

show abstract

“…These "acidifiers" consistently function effectively in spite of the fact that urinary Ca apparently is a limiting constituent required for avian Ca-urate urolith formation, and urinary Ca excretion increases significantly (hypercalciuria) when plasma Ca concentrations are elevated in pullets fed urinary acidifiers (Oldroyd and Wideman, 1986;Glahn et al, 1988a;Wideman et al, 1989;Lent and Wideman, 1994). The latter observation raises the possibility that the hypercalciuria triggered by urinary acidification could interfere with Ca utilization, potentially affecting crucial variables such as bone mineralization, egg production, and eggshell quality (Mongin, 1968;Glahn et al, 1988b;Wideman et al, 1993).…”

Section: Introductionmentioning

confidence: 86%

“…Previous (Lent and Wideman, 1993;Wideman et al, 1989Wideman et al, , 1993; nor were SCWL hens in full production affected when their diets were supplemented with either 1% ammonium chloride or 1% DLM (Glahn et al, 1988b;Koelkebeck et al, 1991). However, the impact of very high (>1%) levels of DLM and HMB on SCWL hens previously had not been evaluated; therefore the present study was designed to evaluate the responses of laying hens to diets containing up to 2% DLM or equimolar (2.25%) HMB.…”

Section: Introductionmentioning

confidence: 97%

“…Diets supplemented with ammonium chloride, ammonium sulfate, DL-Met (DLM), or 2-hydroxy-4-(methylthio)butanoic acid (HMB, Alimet®) all successfully acidify the urine and reduce Ca-induced kidney damage in Single Comb White Leghorn (SCWL) pullets and hens (Wideman and Cowen, 1987;Glahn et al, 1988b;Wideman et al, 1989Wideman et al, , 1993Lent and Wideman, 1993). These "acidifiers" consistently function effectively in spite of the fact that urinary Ca apparently is a limiting constituent required for avian Ca-urate urolith formation, and urinary Ca excretion increases significantly (hypercalciuria) when plasma Ca concentrations are elevated in pullets fed urinary acidifiers (Oldroyd and Wideman, 1986;Glahn et al, 1988a;Wideman et al, 1989;Lent and Wideman, 1994).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Responses of Laying Hens to Diets Containing up to 2% DL-Methionine or Equimolar (2.25%) 2-Hydroxy-4-(Methylthio)Butanoic Acid

Wideman

Ford

Dibner³

et al. 1994

Poultry Science

Self Cite

View full text Add to dashboard Cite

Diets supplemented with up to .6% DL-Met (DLM) or .68% 2-hydroxy-4-(methylthio)butanoic acid (HMB, Alimet) acidify the urine and reduce the incidence of urolithiasis in pullets and laying hens. Excessive acidification potentially may reduce eggshell quality and bone mineralization by interfering with Ca metabolism and may severely challenge the liver and kidneys, which are the primary organs responsible for attenuating metabolic acidosis. To evaluate these possibilities, 30-wk-old Single Comb White Leghorn hens in full production (five hens per replicate, six replicates per diet treatment) were fed for 30 d a 15.7% CP corn and soybean meal-based control layer ration alone or supplemented with DLM (.5, 1, 1.5, or 2%) or equimolar HMB (.56, 1.13, 1.69, or 2.25%). None of the diets caused mortality or gross hepatic or renal damage. Hens fed diets supplemented with the highest levels of DLM and HMB exhibited significant reductions in feed intake, hen-day egg production, and liver mass and had lower plasma concentrations of alanine amino-transferase and isocitrate dehydrogenase when compared with hens fed the control diet. Kidney mass was not significantly affected by high levels of DLM or HMB, but plasma uric acid was significantly higher in hens fed 2% DLM compared with hens fed the control diet. The highest levels of DLM and HMB did not significantly alter total plasma Ca or inorganic phosphate concentrations, nor were percentage eggshell or femur mineralization (femur ash mass:defatted bone mass, femur ash mass:bone volume) significantly reduced.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

“…However, the beneficial effects of calcium can only be attained when the recommended doses are administered. Many metabolic problems, such as diuresis, urolithiasis, visceral gout, and poor pullet performance have been reported to be associated with excessive dietary calcium (Siller, 1981;Wideman and Cowen, 1987;Leeson and Summers, 1987;Wideman et al, 1993;Guo et al, 2005;Julian, 2005). Case histories of affected bird flocks often revealed that excessive calcium had been fed.…”

Section: Introductionmentioning

confidence: 97%

High Dietary Calcium Causes Metabolic Alkalosis in Egg-Type Pullets

et al. 2008

View full text Add to dashboard Cite

One hundred sixty healthy egg-type pullets were randomly divided into 2 groups at 35 d of age. The groups were fed either with a normal-calcium (control, 8.5 g of Ca/kg) diet or with a high-calcium (HC, 36.3 g of Ca/kg) diet, respectively. The experiment lasted for 32 d. The healthy situations of the egg-type pullets were observed. Blood gas values and serum and urine electrolyte content were determined. The HC diet caused watery excreta in pullets. The pullets raised on the HC diet had significantly higher blood pH, bicarbonate, base excess, and significantly lower blood partial pressure of oxygen, partial pressure of carbon dioxide, and oxygen saturation than the pullets raised on the control diet. Phosphorus and potassium decreased; meanwhile, calcium increased in the HC group as compared with the control group. Sodium, magnesium, and chloride in serum had no significant difference between the HC group and the control. The pullets raised on the HC diet had significantly higher urine pH than the pullets raised on the control diet. For HC pullets, urinary concentration and 24-h urinary excretion of calcium and chloride was significantly higher, and magnesium, inorganic phosphorus, and sodium was significantly lower than that of the control pullets. It is concluded that some metabolic disorders associated with high dietary calcium in egg-type pullets may be related to a state of metabolic alkalosis.

show abstract

Liquid Methionine Hydroxy Analog (Free Acid) and DL-Methionine Attenuate Calcium-Induced Kidney Damage in Domestic Fowl

Cited by 8 publications

References 42 publications

Clinicopathology of gout in growing layers induced by high calcium and high protein diets

Clinicopathology of gout in growing layers induced by high calcium and high protein diets

Responses of Laying Hens to Diets Containing up to 2% DL-Methionine or Equimolar (2.25%) 2-Hydroxy-4-(Methylthio)Butanoic Acid

High Dietary Calcium Causes Metabolic Alkalosis in Egg-Type Pullets

Contact Info

Product

Resources

About