Liquid Nanoparticles for Nanocatalytic Cancer Therapy

Abstract

Nanotechnology is revolutionizing cancer therapy, and catalyzes the emerging of ion‐involved cancer‐therapeutic modality, which unfortunately suffers from undesirable nanocarriers for efficient intracellular ion delivery. To radically extricate from this critical issue, the glutathione (GSH)‐responsive organosilica network was employed to lock the liquid drops at the nanoscale via a general bottom‐up strategy to achieve the systemic delivery of “ion drugs”. In this work, a sulfate radical generation donor (Na2S2O8), as a paradigm “ion drug”, was entrapped into this liquid nanoparticle for efficiently delivering to the tumor region. After further surface engineering with pH‐responsive tannic acid‐Fe2+ framework, these liquid nanoparticles achieved tumor‐microenvironmental pH/GSH‐dual responsive ion release (Fe2+/Na+/S2O82−) after reaching the tumor sites, where the Fe2+ further triggered S2O82− to generate toxic •SO4− and •OH, effectively executing cancer cell ferroptosis (Fe2+, ROS) and pyroptosis (Na+, ROS). Such a tumor‐responsive/specific liquid nanoplatform is highly instructive for further ion‐mediated nanomedicine and disease treatment.This article is protected by copyright. All rights reserved

Pyroptosis: a double-edged sword in lung cancer and other respiratory diseases

“…A delivery platform based on macrophage was developed to achieve targeted tumor drug delivery and controlled release [ 101 ]. Some burgeoning nanoplatforms can also stably deliver drugs to activate pyroptosis [ 102 ]. Precisely activating pyroptosis in the tumor site can effectively prevent damage to normal tissues caused by pyroptosis.…”

Zinc–Iron Bimetallic Peroxides Modulate the Tumor Stromal Microenvironment and Enhance Cell Immunogenicity for Enhanced Breast Cancer Immunotherapy Therapy

“…Enhancing the immunogenicity of breast cancer cells is crucial for immune recognition and response. Excitingly, the elevated levels of H 2 O 2 and Fe 2+ in the tumor ECM not only contribute to remodeling the stromal microenvironment of tumors but also have the potential to trigger ferroptosis, which can enhance the immune system’s recognition and response to breast cancer cells . However, the ability of Fe 2+ to induce ferroptosis and activate immune responses is limited due to its low catalytic efficiency in the Fenton reaction and the harsh catalytic conditions required. , Therefore, other strategies for enhancing the immune response triggered by Fe 2+ -mediated ferroptosis need to be explored.…”

Acid-Activated TAT Peptide-Modified Biomimetic Boron Nitride Nanoparticles for Enhanced Targeted Codelivery of Doxorubicin and Indocyanine Green: A Synergistic Cancer Photothermal and Chemotherapeutic Approach

“…The evolution of nano-drug delivery systems has emerged as a pivotal solution to confront the constraints of conventional cancer treatments. − Stimulus-responsive nanomaterial-based delivery systems offer a promising avenue due to their temporal and spatial advantages. , This paradigmatic approach relies on exogenous stimulus-responsive nanocomponents and structural adaptations that enable the precise modulation of drug delivery and release upon exposure to external triggers like light, temperature variations, and magnetic fields. − Boron nitride (BN) nanomaterials, possessing a hexagonal structure similar to that of graphene, have emerged as promising candidates with significant potential applications in drug delivery and cancer treatment in recent years. − Functioning as drug delivery platforms, BN nanomaterials demonstrate high drug loading capacity, multifunctionality, and low toxicity, providing robust support for precise drug delivery and release. − Through surface modification, pH-responsive controlled release of chemotherapeutic drugs can be achieved, enhancing therapeutic efficacy while minimizing side effects on normal tissues . Simultaneously, in boron neutron capture therapy (BNCT), BN nanomaterials serve as carriers for 10 B, releasing high-energy particles through boron neutron capture reactions for precise radiation therapy, offering potential advantages in deep tissue treatment. − …”