Liquid paraffin: a reappraisal of its role in the treatment of constipation

Sharif, Farhana; Crushell, Ellen; O'Driscoll, K; Bourke, Billy

doi:10.1136/adc.85.2.121

Cited by 66 publications

(41 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mineral oil is usually well tolerated and easy to titrate [67]. However, aspiration of mineral oil is associated with lipoid pneumonia, a serious complication [72,73].…”

Section: Mineral Oilmentioning

confidence: 99%

See 1 more Smart Citation

Functional constipation in childhood: current pharmacotherapy and future perspectives

Hoekman¹,

Benninga²

2012

Expert Opinion on Pharmacotherapy

View full text Add to dashboard Cite

Despite the widespread use of laxatives, there is a paucity of evidence to support this practice. No strong conclusions can be drawn on which laxative to prefer over the other. However, polyethylene glycol appears to be a reasonable first choice for maintenance therapy. Due to advances in our understanding of intestinal (patho)physiology, new classes of drugs have been developed. Data from adult studies are promising; however, pediatric data are lacking. Ongoing and future studies have to determine the efficacy and safety of these new drugs in the treatment of functional constipation in children.

show abstract

“…Mineral oil is usually well tolerated and easy to titrate [67]. However, aspiration of mineral oil is associated with lipoid pneumonia, a serious complication [72,73].…”

Section: Mineral Oilmentioning

confidence: 99%

“…Because it is not absorbed in the intestines, it acts as a local lubricant of feces. It may have an osmotic effect as well, when it is converted to hydroxy fatty acids [67]. No placebo-controlled trials have been conducted with mineral oil in children.…”

Section: Mineral Oilmentioning

confidence: 99%

Functional constipation in childhood: current pharmacotherapy and future perspectives

Hoekman¹,

Benninga²

2012

Expert Opinion on Pharmacotherapy

View full text Add to dashboard Cite

show abstract

“…6,8,18 In our study, the tolerability with combination laxatives were considered as good as none of the patients reported any adverse events during the 4-week study period. Present study has several strengths.…”

Section: Discussionmentioning

confidence: 99%

“…5 Liquid paraffin is an emollient laxative which acts by lubricating the passage of stool, thereby reducing the resistance to passage of stools. 6 Sodium picosulphate is a commonly used oral laxative which gets activated to bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM) by the colonic bacteria, thereby stimulating the colonic nerve endings, resulting in enhanced peristalsis and bowel evacuation. In an earlier 4-week study with bisacodyl (5-10 mg daily; n=70) and sodium picosulphate (5-10 mg daily; n=74), in patients with chronic constipation (N=144), a significant improvement in physicians' global assessment was observed in 74.6% patients treated with bisacodyl and 79.2% patients treated with sodium picosulphate.…”

Section: Introductionmentioning

confidence: 99%

A prospective non-comparative study to assess the effectiveness and safety of combination laxative therapy containing milk of magnesia, liquid paraffin and sodium picosulphate (Cremaffin-Plus®) in the management of constipation in patients with anal fissure/hemorrhoids/obstructive defecation syndrome

Patankar

Mishra

2017

Int Surg J

View full text Add to dashboard Cite

Background: Assess the effectiveness and safety of combination laxative therapy containing milk of magnesia, liquid paraffin and sodium picosulphate (Cremaffin-Plus®) in management of constipation, in patients with anal fissure/haemorrhoids/obstructive defecation syndrome (ODS). Methods: Patients visiting study site with complaints of constipation secondary to anal fissures/haemorrhoids/ODS, intended to receive combination laxative therapy (as per physicians' discretion), were enrolled. Primary objectives were to assess the change in number of bowel movements per day and stool consistency; secondary objectives were to assess change in straining, physician global efficacy assessment, quality of life (PAC-QOL score), Constipation Symptoms (CSS), Fecal Incontinence Score (FIS), Patient Assessment of Constipation Symptoms (PAC-SYM) score, along with the Modified Longo Score (MODS) for ODS from baseline to end of 4 weeks. Safety, tolerability and treatment adherence were also assessed. Results: About 32 patients (anal fissure:19, haemorrhoids:5, ODS:8) met inclusion criteria. Significant improvement in stool frequency was observed in all patients pooled together (p=0.016); group wise, statistical significance was noted in patients of anal fissures. Stool consistency was improved in all patients pooled together (p<0.001); group wise, significant improvement was seen in patients of anal fissure and ODS. There was a significant improvement in straining noted in all patients pooled together (p=0.002). Significant reduction (p<0.001) was noted in all the symptom scores (CSS, FIS, PAC-SYM and PAC-QOL) from baseline to 4 weeks in all patients. About 51.44% reduction in MODS score was noted in patients with ODS. Conclusions: Improvement in stool frequency, consistency and straining was noted in all patients with constipation (with fissure/haemorrhoids/ODS) treated with Cremaffin-plus for 4-weeks, improving the quality of life. All patients showed good therapy adherence with better safety and tolerability profile.

show abstract

“…Liquid paraffin is a colourless, almost odourless, highly refined mineral oil composed of saturated hydrocarbons obtained from petroleum 1. Penile paraffinoma is an uncommon entity produced by paraffin injection for the purpose of penile augmentation.…”

Section: Descriptionmentioning

confidence: 99%