Liquid-Phase Exfoliation of Black Sesame to Create A Nanoplatform for
            <i>In Vitro</i>
            Photoluminescence and Photothermal Therapy

Xie, Zhongjian; Lu, Ruitao; Zhu, Yuelin; Peng, Minhua; Fan, Taojian; Ren, Pei‐Gen; Wang, Bing; Kang, Lin; Liu, Xiaoyun; Li, Sha; Cui, Huixian

doi:10.2217/nnm-2020-0151

Cited by 4 publications

(3 citation statements)

References 59 publications

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“…Furthermore, the photothermal performance of the as-prepared borophene is characterized 13 , 43 , 71 , 72 . For the naked borophene, the dispersions for different concentrations are shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Light-induced tumor theranostics based on chemical-exfoliated borophene

et al. 2022

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Among 2D materials (Xenes) which are at the forefront of research activities, borophene, is an exciting new entry due to its uniquely varied optical, electronic, and chemical properties in many polymorphic forms with widely varying band gaps including the lightest 2D metallic phase. In this paper, we used a simple selective chemical etching to prepare borophene with a strong near IR light-induced photothermal effect. The photothermal efficiency is similar to plasmonic Au nanoparticles, with the added benefit of borophene being degradable due to electron deficiency of boron. We introduce this selective chemical etching process to obtain ultrathin and large borophene nanosheets (thickness of ~4 nm and lateral size up to ~600 nm) from the precursor of AlB2. We also report first-time observation of a selective Acid etching behavior showing HCl etching of Al to form a residual B lattice, while HF selectively etches B to yield an Al lattice. We demonstrate that through surface modification with polydopamine (PDA), a biocompatible smart delivery nanoplatform of B@PDA can respond to a tumor environment, exhibiting an enhanced cellular uptake efficiency. We demonstrate that borophene can be more suitable for safe photothermal theranostic of thick tumor using deep penetrating near IR light compared to gold nanoparticles which are not degradable, thus posing long-term toxicity concerns. With about 40 kinds of borides, we hope that our work will open door to more discoveries of this top-down selective etching approach for generating borophene structures with rich unexplored thermal, electronic, and optical properties for many other technological applications.

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Section: Resultsmentioning

confidence: 99%

Light-induced tumor theranostics based on chemical-exfoliated borophene

et al. 2022

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“…Therefore, the application of natural and artificial melanin-based nanomaterials or melanin-like nanoparticles has achieved remarkable results in the field of biomedicine, especially as antitumor PTT ( 241 , 242 ). For example, Xie et al ( 63 ) prepared melanin and cellulose nanosheets (OMCNs) using black sesame hell as raw material by facile liquid-phase exfoliation. They then tested the photothermal properties and ability to kill cells of the OMCNs.…”

Section: Classification Of Photothermal Nanomaterialsmentioning

confidence: 99%

Research Progress of Photothermal Nanomaterials in Multimodal Tumor Therapy

et al. 2022

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The aggressive growth of cancer cells brings extreme challenges to cancer therapy while triggering the exploration of the application of multimodal therapy methods. Multimodal tumor therapy based on photothermal nanomaterials is a new technology to realize tumor cell thermal ablation through near-infrared light irradiation with a specific wavelength, which has the advantages of high efficiency, less adverse reactions, and effective inhibition of tumor metastasis compared with traditional treatment methods such as surgical resection, chemotherapy, and radiotherapy. Photothermal nanomaterials have gained increasing interest due to their potential applications, remarkable properties, and advantages for tumor therapy. In this review, recent advances and the common applications of photothermal nanomaterials in multimodal tumor therapy are summarized, with a focus on the different types of photothermal nanomaterials and their application in multimodal tumor therapy. Moreover, the challenges and future applications have also been speculated.

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“…Extracts from plants and animals provide several alternatives for the reformation of photothermal agents. Squid ink [ 20 , 21 ], bamboo charcoal [ 22 , 23 ], fruit-extracted anthocyanins [ 24 , 25 ], and black sesame [ 26 , 27 ] have been used to prepare photothermal agents which show brilliant biocompatibility. However, these bio-inspired photothermal agents exhibit inherent problems such as low accumulation in tumors, easy diffusion and fast elimination, which may cause side effects.…”

Section: Introductionmentioning

confidence: 99%

In Situ Biosynthesis of Photothermal Parasite for Fluorescence Imaging-Guided Photothermal Therapy of Tumors

Wang

Pan

Meng

et al. 2022

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Photothermal therapy (PTT) has been widely known as a promising therapeutic strategy for cancer treatment in recent decades. However, some organic and inorganic photothermal agents exhibit shortcomings including potential long-term toxicity and lack of biodegradability. Biocompatible extracts from plants and animals provide several alternatives for the reformation of photothermal agents. Bio-inspired products still have inherent problems such as low accumulation in tumors, easy diffusion, and fast elimination. Herein, we aim to develop a biocompatible photothermal agent with tumor enrichment. Enlightened by “parasitized snails”, in situ biosynthesis of photothermal agents and fluorescence imaging-guided PTT are achieved with the assistance of alginate–calcium–genipin (ACG) hydrogel. ACG hydrogel is a mixture of alginate (ALG), calcium (Ca), and genipin (GP). Given that the crosslinking product of GP and protein displays fluorescent/photothermal features, the constructed ACG hydrogel can gradually react with the tumor and then “light up” and “ignite” the tumor under specific light excitation. The ACG hydrogel can be seen as a photothermal parasite, eventually leading to the death of tumor. The photothermal therapeutic effects of ACG hydrogel reacting with tumors are successfully proven in vivo. The naturally derived GP and ALG ensure the biosafety of the ACG hydrogel-based bio-application. This work is another successful practice of nature-inspired methodological strategy for in situ biosynthesis of the photothermal agent.

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Liquid-Phase Exfoliation of Black Sesame to Create A Nanoplatform for In Vitro Photoluminescence and Photothermal Therapy

Cited by 4 publications

References 59 publications

Light-induced tumor theranostics based on chemical-exfoliated borophene

Light-induced tumor theranostics based on chemical-exfoliated borophene

Research Progress of Photothermal Nanomaterials in Multimodal Tumor Therapy

In Situ Biosynthesis of Photothermal Parasite for Fluorescence Imaging-Guided Photothermal Therapy of Tumors

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