Nowadays, the liquid−solid triboelectric nanogenerator (L-S TENG) has gained much attention among researchers because of its ability to be a part of self-powering technology by harvesting ultra-low-frequency vibration in the environment. The L-S TENG works with the principle of contact electrification (CE) and electrostatic induction, in which CE takes place between the solid and liquid. The exact mechanism behind the CE at the L-S interface is still a debatable topic because many physical parameters of both solid and liquid triboelectric layers contribute to this process. In the L-S TENG device, water or solvents are commonly used as liquid triboelectric layers, for which their wettability over the solid triboelectric layer plays a significant role. Hence, this review is extensively focused on the influence of the wettability of solid surfaces on the CE and the corresponding impact on the output performance of L-S TENGs. The present review starts with introducing the L-S TENG, a mechanism that contributes to CE at the L-S interface, the significance of hydrophobic materials/surfaces in TENG devices, and their fabrication methods. Further, the impact of the contact angle over the electron/ion transfer over various surfaces has been extensively analyzed. Finally, the challenges and future prospects of the fabrication and utilization of superhydrophobic surfaces in the context of L-S TENGs have been included. This review serves as a foundation for future research aimed at optimizing the L-S TENG performance and inspiring new approaches in material design and multifunctional energy-harvesting systems.