Liquisolid Technology: Preparation, Characterization and Applications

Abstract

With the advent of high throughput screening, drugs are emerging to be more lipophilic and less hydrophilic. Liquisolid Technology aims at solubility enhancement of such entities via cosolvency concept in a relatively minimalistic setup where there is no need of sophisticated machinery and is cost effective. It involves constituting a drug into molecular dispersion via a non-volatile solvent and then transforming it into a dry looking, free flowing compressible powder. This article aims at mapping Liquisolid Technology where its preparation techniques and potential applications are reviewed. An overview of the performance of Liquisolid in areas of dissolution enhancement, zero order release, photostability enhancement, liquipellets and its role in natural product formulations is recorded for a number of drugs.
 Keywords: Liquisolid, Dissolution Enhancement, Flowability, Compressibility, Cosolvency

Exploring Multifaceted Changes in Physicochemical and Nutritional Attributes of Chicken Breast Powder under Cold Plasma Treatment

“…Carr’s index and Hausner ratio serve as metrics to evaluate material flow characteristics, compressibility, and particle interactions. Higher values of Carr’s index and Hausner ratio indicate lower flowability, while lower values suggest enhanced flowability. , In this study, the Carr’s index and Hausner ratio of CP-5, CP-10, and CP-15 decreased by 14.52, 21.75, and 24.33%, and 2.62, 3.88, and 3.46%, respectively, relative to CP-0. According to Carr and Gorle and Chopade, materials are categorized as having good or fair flow properties if their Carr’s index and Hausner ratio fall within the ranges of 11–15 and 1.12–1.18, and 16–20 and 1.19–1.25, respectively.…”

“…Higher values of Carr's index and Hausner ratio indicate lower flowability, while lower values suggest enhanced flowability. 31,32 In this study, the Carr's index and Hausner ratio of CP-5, CP-10, and CP-15 decreased by 14.52, 21.75, and 24.33%, and 2.62, 3.88, and 3.46%, respectively, relative to CP-0. According to Carr 33 and Gorle and Chopade, 31 evident from Table 1 that the values of Carr's index and Hausner ratio in this study align with these reference ranges.…”

“…31,32 In this study, the Carr's index and Hausner ratio of CP-5, CP-10, and CP-15 decreased by 14.52, 21.75, and 24.33%, and 2.62, 3.88, and 3.46%, respectively, relative to CP-0. According to Carr 33 and Gorle and Chopade, 31 evident from Table 1 that the values of Carr's index and Hausner ratio in this study align with these reference ranges. Consequently, it can be inferred that flowability may exhibit a slight improvement with an increasing cold plasma treatment duration.…”

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“…Among the various novel techniques for promoting dissolution, the liquisolid formulation is the most unique and new method of approach. [10] Liquisolid systems are powdered type of liquid medications that are well flowing and compressible, immersing the poorly soluble drug in an oily vehicle or solution. The liquid medication can be transformed into a free-flowing and good compressible powder by blending a liquid drug with selected powder excipients known as the carrier and coating material which was added based on the new mathematical model of liquisolid system.…”

Diseño de recubrimientos porosos basados en circona mediante proyección térmica por plasma de suspensiones concentradas Carnicer Cervera, Víctor

“…Tabla 8. Clasificación de la fluidez de los materiales pulverulentos en función del índice de Hausner y el ángulo de reposo [204].…”