Liquor amnii analysis in the management of the pregnancy complicated by rhesus sensitization

Liley, Andrew

doi:10.1016/s0002-9378(16)36265-2

Cited by 691 publications

(188 citation statements)

References 19 publications

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“…Escenario Clínico: en el manejo de pacientes Rh negativo sensibilizadas, la evaluación de la concentración de bilirrubina en el líquido amniótico, mediante espectrofotometría, ha sido utilizada para estimar la presencia de anemia fetal (2). La obtención de líquido amniótico, mediante amniocentesis, es un procedimiento invasivo, no exento de riesgos.…”

Section: Análisis De La Investigaciónunclassified

Ultrasonografía Doppler versus amniocentesis para predecir anemia fetal: Resultados de un estudio multicéntrico randomizado

U¹,

Carvajal

2007

Rev. chil. obstet. ginecol.

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Section: Análisis De La Investigaciónunclassified

Ultrasonografía Doppler versus amniocentesis para predecir anemia fetal: Resultados de un estudio multicéntrico randomizado

U¹,

Carvajal

2007

Rev. chil. obstet. ginecol.

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“…Similar observations have been made by other researchers. 1,5,14 We have also observed that as gestational age advances, fetal MCA-PSV can be better evaluated as the vessel can be better identified and sampled. This fact is depicted in that the fetus is anemic.…”

mentioning

confidence: 92%

“…But the invasive nature of these tests was a deterrent to their wide scale use for screening of unsuspected fetuses. 1,2 Hence, soon after the discovery that elevated fetal middle cerebral artery peak systolic velocity (MCA-PSV) can indicate fetal anemia satisfactorily and noninvasively, Doppler ultrasound of fetal MCA received a warm welcome all over the globe. 3,4 Literature on this technique from India is scanty and hence this study was, therefore, undertaken with an aim to demonstrate the normal values of fetal MCA-PSV at various gestational ages in an Indian setting by using the standard internationally accepted protocol.…”

Section: Introductionmentioning

confidence: 99%

An Untold Story of Indian Fetal Middle Cerebral Artery Peak Systolic Velocities

Gandage¹,

Pawar²,

Kachewar³

2014

International Journal of Infertility &Amp; Fetal Medicine

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Although noninvasive diagnosis of anemia in fetus by measuring the middle cerebral artery peak systolic velocity (MCA-PSV) is practised and extensively researched in the developed world, such studies from the developing world are rare. India is the home for many hemoglobinopathies and cases of Rh alloimmunization are also reported here. Hence, it is expected that fetal anemias will be quite common. So in addition to an awareness about the correct method of measuring MCA-PSV and knowledge about changes that occur in the waveforms with advancing gestational age, it is important to know the normal values at various gestational ages in an Indian setting. Demonstrating these normal values was the primary goal of the current study.Context: Fetal anemia can be adequately tackled only if it is diagnosed on time. Fetal MCA-PSV has the potential to reliably predict fetal anemia. Scientific studies across the globe are a testimony to this fact. As such studies from rural setups are lacking, this study was initiated. Aims:To demonstrate the normal values of fetal MCA-PSV at various gestational ages in an Indian setting by using the standard internationally accepted protocol. Settings and design:The ultrasound wing of radiodiagnosis department of a rural medical college was the site of this study. Permission from institutional research cell and ethical committee was obtained for study on fetal MCA-PSV. Written informed consent from every pregnant mother who participated in the study was also obtained. A cross-sectional and prospective observational study was conducted over the last 9 months. materials and methods: A total of 60 measurements of fetal MCA-PSV were conducted in normal 20 pregnant women referred for routine obstetric scan at 12, 24, and 36 weeks of gestation respectively, by a single radiologist on color Doppler ultrasound machine. In each fetus the proximal MCA, soon after its origin, was evaluated. Statistical analysis:The observations were entered in Microsoft Excel sheet and statistical analysis was done by using SPSS statistical software version 12. The relation between fetal MCA-PSV and gestational age was studied using the Karl Pearson's correlation coefficient. The significance of difference was studied using the t-test.Results: MCA-PSV increased with increasing gestational age, suggesting positive correlation between the two. Better waveforms and increasing PSV were visualized with advancing gestational age. Conclusion:Fetal anemia can be accurately predicted only if the MCA-PSV is scientifically measured and compared with normal values in a given setting. This study demonstrates the normal values at various gestational ages in an Indian setting.

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“…Liley (1) , em 1961, descreveu método de leitura espectrofotométrica para determinar indiretamente a concentração de bilirrubina no líquido amniótico e avaliar o estado hemolítico, e o possível estado hematimétrico do concepto. A espectrofotometria precedida da amniocentese converteuse em técnica de aceitação geral e passou a ser considerada básica no manuseio da gestante sensibilizada ao fator Rh.…”

Section: Introductionunclassified

Alterações ultra-sonográficas na gravidez Rh negativo sensibilizada avaliada pela espectrofotometria do líquido amniótico e pela dopplervelocimetria da artéria cerebral média

Nardozza¹,

Camano²,

Moron³

et al. 2006

Radiol Bras

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OBJETIVO: Avaliar e confrontar a presença de alterações ultra-sonográficas nas gestações Rh negativo sensibilizadas, quando a anemia fetal foi determinada ou pela espectrofotometria do líquido amniótico, ou pela dopplervelocimetria da artéria cerebral média. MATERIAIS E MÉTODOS: Observacional descritivo com grupo de comparação. Nosso grupo de estudo foi constituído por 99 pacientes, avaliadas no período de janeiro de 1995 a janeiro de 2004. Foram analisados e comparados dois grupos: 74 gestantes sensibilizadas pelo fator Rh cuja anemia fetal foi acompanhada pela espectrofotometria (grupo SE) e 25 gestantes sensibilizadas pelo fator Rh cuja anemia fetal foi acompanhada pela dopplervelocimetria (grupo SD). Avaliamos a presença ou não de alterações ultra-sonográficas no acompanhamento pré-natal e confrontamos os dois grupos de estudo. RESULTADOS: No grupo cuja anemia fetal foi acompanhada através da espectrofotometria (grupo SE), apuramos modificações placentárias, principalmente o aumento da espessura e sua alteração textural, mais assiduamente que as encontradiças no grupo de gestantes sensibilizadas, em que a anemia foi determinada através da dopplervelocimetria (grupo SD) (64% × 32%, F = 6,294). CONCLU-SÃO: As alterações ultra-sonográficas foram detectadas em dobro quando a anemia foi avaliada pela espectrofotometria em comparação com o grupo seguido pela dopplervelocimetria. Unitermos: Isoimunização; Anemia fetal; Artéria cerebral média; Ultra-som Doppler; Aloanticorpos; Eritroblastose fetal.Ultrasound findings in Rh-alloimmunized pregnancies assessed by spectrophotometric analysis of amniotic fluid and Doppler velocimetry of fetal middle cerebral artery. OBJECTIVE: To evaluate and compare existing ultrasound findings in women with Rh-alloimmunized pregnancies with diagnosis of fetal anemia by spectrophotometric analysis of amniotic fluid or Doppler ultrasound of the fetal middle cerebral artery. MATERIALS AND METHODS: This was an observational descriptive study involving 99 patients evaluated between January 1995 and January 2004. Patients were divided into two groups: 74 Rh-isoimmunized women submitted to spectrophotometry of the amniotic fluid (group S) and 25 Rh-isoimmunized women submitted to Doppler ultrasound of fetal middle cerebral artery (group D) to evaluate fetal anemia. Ultrasound findings in the two groups were compared. RESULTS: Placental anomalies, mainly placentomegaly and textural irregularities were more frequently seen in pregnant women followed up with spectrophotometry of the amniotic fluid compared to those followed up with Doppler ultrasound (64% × 32%, F = 6,294). CONCLUSION: The frequency of abnormal ultrasound findings was 2-fold higher in pregnancies evaluated with spectrophotometry of the amniotic fluid compared to those followed up with Doppler ultrasound. INTRODUÇÃOA aloimunização pelas células vermelhas do sangue é caracterizada por ser distúrbio imunológico conseqüente a incompatibilidade sanguínea materno-fetal, que determina doença hemolítica no feto e recém-nascido. Há dest...

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Liquor amnii analysis in the management of the pregnancy complicated by rhesus sensitization

Cited by 691 publications

References 19 publications

Ultrasonografía Doppler versus amniocentesis para predecir anemia fetal: Resultados de un estudio multicéntrico randomizado

Ultrasonografía Doppler versus amniocentesis para predecir anemia fetal: Resultados de un estudio multicéntrico randomizado

An Untold Story of Indian Fetal Middle Cerebral Artery Peak Systolic Velocities

Alterações ultra-sonográficas na gravidez Rh negativo sensibilizada avaliada pela espectrofotometria do líquido amniótico e pela dopplervelocimetria da artéria cerebral média

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