Liquor Bilirubin Levels in Normal Pregnancy: A Reassessment of Early Prediction of Haemolytic Disease

Murray, John; Norrie, D. L.; Ruthven, C.R.J.

doi:10.1136/bmj.4.5732.387

Cited by 10 publications

(1 citation statement)

References 23 publications

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“…Early spectrophotometric methods, developed by Bevis (1956 and earlier work), Walker (1957) and Liley (1961), were found to have some disadvantages (Liley, 1963), particularly if the specimen contained methaem pigments arising either from contamination with blood during previous amniocentesis or intrauterine transfusion, or in cases of imminent or actual fetal death (Walker et al, 1964). Procedures to overcome these disadvantages have been suggested, including chemical estimation (Gambino et al, 1966, Kruijswijk et al, 1966, Watson et al, 1965, solvent extraction with subsequent spectrophotometric measurement (Brazie et al, 1969, Mallikarjuneswara et al, 1970, empirical equations based on spectrophotometric observations (Knox et al, 1965, Bjerre et al, 1968, and the use of bile pigment/protein ratios (Murray et al, 1970). We have had considerable experience of three such methods; Liley's method (1961), the empirical equation method of Knox et al (1965) modified by Whitfield (personal 'communication, 1974), and the solvent extraction of Mallikrajuneswara et at.…”

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confidence: 97%

Determination of Bilirubin in Amniotic Fluid: A Comparison of Some Current Methods

Simkins

Worth

1976

Ann Clin Biochem

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Three methods for the estimation of bilirubin in amniotic fluid are compared. The within-batch precision and recovery of bilirubin by each method has been studied, and the effects of the presence of haemoglobin, methaemoglobin, and methaemalbumin in varying concentrations have been investigated. Measurements on amniotic fluid from patients with rhesus isioimmunization have also been compared and regression equations calculated. The results of the three methods agree reasonably well so long as no haemoglobin degradation products are present. It is suggested that in the presence of these products a method involving organic solvent extraction of bilirubin gives the most accurate result.

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confidence: 97%

Determination of Bilirubin in Amniotic Fluid: A Comparison of Some Current Methods

Simkins

Worth

1976

Ann Clin Biochem

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Recent Advances in the Separation and Analysis of Diazo‐Positive Bile Pigments

Heirwegh

Fevery

Meuwissen

et al. 1974

Methods of Biochemical Analysis

113

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Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus

et al. 2016

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Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks of gestation and were followed up until delivery. The value of bilirubin was tested and oral glucose tolerance test was conducted to screen gestational diabetes mellitus. The relationship between serum bilirubin concentration and gestational weeks was studied by two-piecewise linear regression. A subsample of 1135 participants with serum bilirubin test during 16-18 weeks gestation was conducted to research the association between serum bilirubin levels and risk of gestational diabetes mellitus by logistic regression. Gestational diabetes mellitus developed in 8.5 % of the participants (223 of 2969). Two-piecewise linear regression analyses demonstrated that the levels of bilirubin decreased with gestational week up to the turning point 23 and after that point, levels of bilirubin were increased slightly. In multiple logistic regression analysis, the relative risk of developing gestational diabetes mellitus was lower in the highest tertile of direct bilirubin than that in the lowest tertile (RR 0.60; 95 % CI, 0.35-0.89). The results suggested that women with higher serum direct bilirubin levels during the second trimester of pregnancy have lower risk for development of gestational diabetes mellitus.

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Liquor Bilirubin Levels in Normal Pregnancy: A Reassessment of Early Prediction of Haemolytic Disease

Cited by 10 publications

References 23 publications

Determination of Bilirubin in Amniotic Fluid: A Comparison of Some Current Methods

Determination of Bilirubin in Amniotic Fluid: A Comparison of Some Current Methods

Recent Advances in the Separation and Analysis of Diazo‐Positive Bile Pigments

Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus

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