2023
DOI: 10.33029/2304-9529-2023-12-4-117-131
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Liraglutide and sibutramine: similarities and differences in pharmacotherapy of obesity

T.I. Romantsova

Abstract: The centrally acting anti-obesity drugs currently registered in the Russian Federation include liraglutide 3.0 mg (Saxenda®, Enligria®) and a number of sibutramine-containing drugs, including Reduxin®, Reduxin Forte®. This literature review compares data on the mechanisms of action of these drugs and their effect on homeostatic and hedonistic regulation of body weight, production of glucagon-like peptide-1, and gut microbiota. Information is provided on the effects of these drugs on major metabolic parameters,… Show more

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