Liraglutide Is Protective against Brain Injury in Mice with Febrile Seizures by Inhibiting Inflammatory Factors

Abstract

The febrile seizure (FS) is a common disease in emergency pediatrics, and about 30% of patients are children aged between 6 months and 5 years. Therefore, we aim to observe the protective impact of liraglutide (LIR) on brain injury in mice with FS and to explore its relevant mechanisms. Male SD mice were selected, and the FS model was established by heat bath method. The behavioral score was performed on mice with Racine grading, and nerve cells in apoptosis in the hippocampus were determined by TUNEL. The content of glutamate was determined by ELISA. mRNA levels and protein expression of GLP-1, GLP-1R, IL-1β, IL-6, TNF-α, and cleaved-caspase 3 were examined in mice by q-PCR and WB. Protein expression of γ-aminobutyric acid was influenced by WB as well. LIR prolonged the seizure latency and seizure duration in mice with FS. The GLP-1 and GLP-1R in the mouse hippocampus with FS expressed highly and also inhibited the number of nerve cells in apoptosis, decreased glutamate content, and increased γ-aminobutyric acid expression in the mouse hippocampus with FS. In addition, The IL-1β, IL-6, and TNF-α, in the mouse hippocampus with FS expressed to reduce with LIR. LIR is protective against brain injury in mice with FS and protects brain injury by inhibiting inflammatory factors in mice with FS. Our finding provides a reference for mitigating and delaying the development of FS as well as the prevention and treatment of brain injury caused by FS.

Convulsão Febril Em Crianças: Fatores De Prevenção De Sua Recorrência E Manejo Clínico Na Emergência

“…Estão dispostos na tabela 1 mais detalhes sobre os dados obtidos. De acordo com Wang et al (2022), as convulsões febris, que acontecem com certa frequência durante a infância, principalmente entre as idades de 6 meses e 5 anos, são decorrentes de uma interação complexa de fatores genéticos, processos imunoinflamatórios e ativação da rede de citocinas. Caso tal enfermidade ocorra de forma crônica, cerca de 7% das crianças podem apresentar complicações, como a epilepsia pré-púbere com lesão neuronal grave.…”

“…Descrição dos resultados obtidos para a composição do trabalho et al (2022); EILBERT;CHAN, 2022;JAIN;SANTHOSH, 2021;WANG et al (2022);RAGHAVAN et al (2021).…”

Synergistic effects of GABA and hypoglycemic drugs

“…Нокдаун экспрессии GLP1R в alBST продлевает реакцию гипоталамо-гипофизарно-надпочечниковой оси на острый стресс. Учитывая данные о том, что ГАМК-ергическая проекция от вентрального alBST служит для ограничения реакции индуцированной стрессом оси гипоталамус-гипофиз-надпочечники, можно предположить, что передача сигналов ГПП-1 приводит к активации ГАМК-ергических вентральных нейронов alBST, которые проецируются непосредственно в паравентрикулярное ядро гипоталамуса (PVN) [ 20 ][ 32 ][ 35 ][ 36 ]. Эти данные раскрывают механизм взаимодействия ГПП-1Р и ГАМК, посредством которых alBST осуществляет ингибирующий контроль над эндокринной осью гипоталамус-гипофиз-надпочечники.…”

Retracted: Liraglutide Is Protective against Brain Injury in Mice with Febrile Seizures by Inhibiting Inflammatory Factors

“…Computational and Mathematical Methods in Medicine has retracted the article titled “Liraglutide Is Protective against Brain Injury in Mice with Febrile Seizures by Inhibiting Inflammatory Factors” [ 1 ] due to concerns that the peer review process has been compromised.…”

“…Computational and Mathematical Methods in Medicine has retracted the article titled "Liraglutide Is Protective against Brain Injury in Mice with Febrile Seizures by Inhibiting Inflammatory Factors" [1] due to concerns that the peer review process has been compromised. Following an investigation conducted by the Hindawi Research Integrity team [2], significant concerns were identified with the peer reviewers assigned to this article; the investigation has concluded that the peer review process was compromised.…”