Liraglutide treatment effects on rat ovarian and uterine tissues

Saber, Sara; El‐Rahman, Heba Ali Abd

doi:10.1016/j.repbio.2019.07.003

Cited by 6 publications

(2 citation statements)

References 31 publications

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“…Indeed, some effects of GLP-1 receptor agonists (e.g., food reward, weight loss) were dependent on, or potentiated by, estrogens in female rodents (Asarian et al 2012 ; Richard et al 2016 ; Maske et al 2017 ). Conversely, GLP-1 receptor agonists were shown to affect gonadal function in female rodents (Outeiriño-Iglesias et al 2015 ; Saber and Abd El-Rahman 2019 ). How these interactions may explain the reduced effects of exendin-4 in the present study is also unclear.…”

Section: Discussionmentioning

confidence: 99%

Sex-dependent divergence in the effects of GLP-1 agonist exendin-4 on alcohol reinforcement and reinstatement in C57BL/6J mice

Díaz-Megido¹,

Thomsen²

2023

Psychopharmacology

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Rationale Alcohol use disorder remains a leading cause of preventable deaths, and current treatments have limited efficacy. Glucagon-like peptide 1 (GLP-1) receptor agonists can reduce alcohol drinking in preclinical studies, but mechanisms are still not fully understood, and data in female subjects are scarce. Objectives To assess whether the GLP-1 receptor agonist exendin-4 could decrease alcohol-seeking behavior in the absence of alcohol consumption or intoxication, to compare the potency and efficacy of exendin-4 in the reduction of alcohol seeking vs. alcohol taking, and to compare effects between male and female mice. Methods Male and female C57BL/6J mice were trained to self-administer 20% alcohol under an FR 1 schedule of reinforcement. After extinction, systemic exendin-4 (saline, 1.8, and 3.2 μg/kg) was tested in cue-induced reinstatement of alcohol seeking. Effects of exendin-4 on alcohol self-administration were tested in a separate group. Results Exendin-4 suppressed reinstatement of alcohol seeking to extinction levels, at both doses, in the male mice, but had no effect in the female mice. Both doses of exendin-4 also significantly decreased alcohol self-administration in male mice; females again showed less pronounced effects. Conclusions In male mice, exendin-4 appeared more effective at suppressing alcohol seeking in the absence of alcohol relative to alcohol self-administration, consistent with modulation of alcohol reward or inhibitory control, rather than satiety or aversive effects of alcohol. We saw marked sex differences with less effect of exendin-4 in female mice, and it will be important to include both sexes in further investigations into GLP-1 receptor agonists.

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Section: Discussionmentioning

confidence: 99%

Sex-dependent divergence in the effects of GLP-1 agonist exendin-4 on alcohol reinforcement and reinstatement in C57BL/6J mice

Díaz-Megido¹,

Thomsen²

2023

Psychopharmacology

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“…(1) Clinical efficacy [7] was measured after 12 weeks. Obviously efficacy: FPG < 7.0 mmol/L or reduced by > 30%; effective: FPG < 8.5 mmol/L or reduced by 10-29%; ineffective: FPG showed no significant change or decreased by less than 10%.…”

Section: Outcome Measuresmentioning

confidence: 99%

Effect of Liraglutide combined with Jinlida granules on glycolipid metabolism and islet function of type 2 diabetes mellitus

Xianjuan Wang,

Kun He,

Jing Li

et al. 2024

Cell Mol Biol (Noisy-le-grand)

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Materials and methods Clinical data90 patients with T2DM from October 2021 to February 2023 were selected. A control group and an observation group were established by the random number table method. In the control group, there were 26 males and 19 females, aged from 41 to 78 years with an average age of (59.67±5.31) years. The course of disease ranged from 6 months to 9 years, with an average of (2.58 ± 0.56) years. BMI ranges from 18.5 to 28.3 kg/m 2 , with an average of (23.01 ± 1.26) kg/m 2 . The observation group included 24

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Pharmacological and non-pharmacological interventions for improving endometrial receptivity in infertile patients with polycystic ovary syndrome: a comprehensive review of the available evidence

Palomba,

Costanzi,

Caserta

et al. 2024

Reproductive BioMedicine Online

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Liraglutide treatment effects on rat ovarian and uterine tissues

Cited by 6 publications

References 31 publications

Sex-dependent divergence in the effects of GLP-1 agonist exendin-4 on alcohol reinforcement and reinstatement in C57BL/6J mice

Sex-dependent divergence in the effects of GLP-1 agonist exendin-4 on alcohol reinforcement and reinstatement in C57BL/6J mice

Effect of Liraglutide combined with Jinlida granules on glycolipid metabolism and islet function of type 2 diabetes mellitus

Pharmacological and non-pharmacological interventions for improving endometrial receptivity in infertile patients with polycystic ovary syndrome: a comprehensive review of the available evidence

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