Liranaftate loaded Xanthan gum based hydrogel for topical delivery: Physical properties and ex-vivo permeability

Mishra, Bibaswan; Sahoo, Sabuj; Sahoo, Susijit

doi:10.1016/j.ijbiomac.2017.10.039

Cited by 24 publications

(5 citation statements)

References 26 publications

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“…Therefore, it was concluded that the mechanism of transport for all these formulations followed an anomalous (non-Fickian) behavior, as described in Table 6, possibly including both diffusion and/or polymer erosion phenomena. These results are in accordance with those reported for zaltoprofen and griseofulvin MBGs (47,66,67) and contraceptive vagino-adhesive propranolol HCl gel (68).…”

Section: Drug Release Kineticssupporting

confidence: 92%

Preparation and Characterization of Lidocaine-Loaded, Microemulsion-Based Topical Gels

et al. 2022

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: Microemulsion-based gels (MBGs) were prepared for transdermal delivery of lidocaine and evaluated for their potential for local anesthesia. Lidocaine solubility was measured in various oils, and phase diagrams were constructed to map the concentration range of oil, surfactant, cosurfactant, and water for oil-in-water (o/w) microemulsion (ME) domains, employing the water titration method at different surfactant/cosurfactant weight ratios. Refractive index, electrical conductivity, droplet size, zeta potential, pH, viscosity, and stability of fluid o/w MEs were evaluated. Carbomer® 940 was incorporated into the fluid drug-loaded MEs as a gelling agent. Microemulsion-based gels were characterized for spreadability, pH, viscosity, and in-vitro drug release measurements, and based on the results obtained, the best MBGs were selected and subsequently subjected to ex-vivo rat skin permeation anesthetic effect and irritation studies. Data indicated the formation of nano-sized droplets of MEs ranging from 20 - 52 nm with a polydispersity of less than 0.5. In-vitro release and ex-vivo permeation studies on MBGs showed significantly higher drug release and permeation in comparison to the marketed topical gel. Developed MBG formulations demonstrated greater potential for transdermal delivery of lidocaine and advantage over the commercially available gel product, and therefore, they may be considered as potential vehicles for the topical delivery of lidocaine.

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Section: Drug Release Kineticssupporting

confidence: 92%

Preparation and Characterization of Lidocaine-Loaded, Microemulsion-Based Topical Gels

et al. 2022

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“…Pure xanthan gels are stable under acidic and neutral pH, as in alkaline conditions ester bonds are hydrolyzed [ 115 ]. While there are numerous reports concerning XG hydrogels of various forms, e.g., [ 119 , 120 ], the review below is focused on micro- and nanogel structures and micro-/nanoencapsulation of actives where a crosslinking agent is used. Such formulation technologies have been employed most often for the design of sustained-release oral dosage forms (including gastroretentive ones) or targeted colonic delivery of locally acting drugs.…”

Section: Gum-based Micro- and Nanoparticles In Drug Deliverymentioning

confidence: 99%

Natural Gums in Drug-Loaded Micro- and Nanogels

et al. 2023

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Gums are polysaccharide compounds obtained from natural sources, such as plants, algae and bacteria. Because of their excellent biocompatibility and biodegradability, as well as their ability to swell and their sensitivity to degradation by the colon microbiome, they are regarded as interesting potential drug carriers. In order to obtain properties differing from the original compounds, blends with other polymers and chemical modifications are usually applied. Gums and gum-derived compounds can be applied in the form of macroscopic hydrogels or can be formulated into particulate systems that can deliver the drugs via different administration routes. In this review, we present and summarize the most recent studies regarding micro- and nanoparticles obtained with the use of gums extensively investigated in pharmaceutical technology, their derivatives and blends with other polymers. This review focuses on the most important aspects of micro- and nanoparticulate systems formulation and their application as drug carriers, as well as the challenges related to these formulations.

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“…The Zeta sizer (Gondkar et al, 2017) quantifies zeta potential. Using a suitable procedure, the amount of drug released from the TEs is added to the solution, which is then subjected to spectrophotometric or chromatographic analysis to evaluate its drug concentration (Mishra et al, 2018; Shaji & Bajaj, 2018). Entrapment efficiency, drug release, and vesicle yield are measured using separation techniques (Ultracentrifugation or dialysis bag method) followed by spectroscopic or chromatographic (High Performance Liquid Chromatography) or colorimetric studies (Shaji & Bajaj, 2018) to collect correct info on the medication that the vesicles are supposed to contain.…”

Section: Transdermal Systemmentioning

confidence: 99%

Transethosomes: Cutting edge approach for drug permeation enhancement in transdermal drug delivery system

Nayak¹,

Mohanty²,

Mishra³

et al. 2023

Chem Biol Drug Des

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The skin is a major route of drug administration. Despite the high surface area of the skin, drug delivery via the skin route is problematic due to its physiological obstacles. The formulation scientist has developed a vesicular system to enhance the skin's absorption of bioactive substances. Among numerous vesicular systems, concept of transethosomes (TEs) introduced in 2012 are being tested for drug delivery to the dermis. When transferosomes and ethosomes interact, TEs are produced. It consists of water, ethanol, phospholipids, and an edge activator. Ethanol and the edge activator increase the absorption of medication through the skin. In the presence of ethanol and an edge activator, skin permeability can increase. The advantages of TEs include increased patient compliance, bypassing first‐pass metabolism, including non‐toxic raw components, being a noninvasive method of drug delivery, being more stable, biocompatible, biodegradable, and administered in semisolid form. TEs can be produced through the use of hot, cold, mechanical dispersion, and conventional techniques. The morphology, shape, size, zeta potential, drug loading efficiency, vesicle yield, biophysical interactions, and stability of TEs define them. Recent studies reported successful transdermal distribution of antifungal, antiviral, anti‐inflammatory, and cardiovascular bioactive while using ethosomes with significant deeper penetration in skin. The review extensively discussed various claims on TEs developed by researchers, patents, and marketed ethosomes. However, till today no patens being granted on TEs. There are still lingering difficulties related to ethanol‐based TEs that require substantial research to fix.

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Liranaftate loaded Xanthan gum based hydrogel for topical delivery: Physical properties and ex-vivo permeability

Cited by 24 publications

References 26 publications

Preparation and Characterization of Lidocaine-Loaded, Microemulsion-Based Topical Gels

Preparation and Characterization of Lidocaine-Loaded, Microemulsion-Based Topical Gels

Natural Gums in Drug-Loaded Micro- and Nanogels

Transethosomes: Cutting edge approach for drug permeation enhancement in transdermal drug delivery system

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