Deepfake detection methods have shown promising results in recognizing forgeries within a given dataset, where training and testing take place on the in-distribution dataset. However, their performance deteriorates significantly when presented with unseen samples. As a result, a reliable deepfake detection system must remain impartial to forgery types, appearance, and quality for guaranteed generalizable detection performance. Despite various attempts to enhance cross-dataset generalization, the problem remains challenging, particularly when testing against common post-processing perturbations, such as video compression or blur. Hence, this study introduces a deepfake detection framework, leveraging a self-supervised pre-training model that delivers exceptional generalization ability, withstanding common corruptions and enabling feature explainability. The framework comprises three key components: a feature extractor based on vision Transformer architecture that is pre-trained via self-supervised contrastive learning methodology, a graph convolution network coupled with a Transformer discriminator, and a graph Transformer relevancy map that provides a better understanding of manipulated regions and further explains the model's decision. To assess the effectiveness of the proposed framework, several challenging experiments are conducted, including in-data distribution performance, cross-dataset & cross-manipulation generalization, and robustness against common post-production perturbations. The results achieved demonstrate the remarkable effectiveness of the proposed deepfake detection framework, surpassing the current state-of-theart approaches.