List of Contributors

Alazem, Mazen; Al-Tuwariqi, Hani Z.; Barba, M.; Boubourakas, I. N.; Çağlayan, Kadriye; Candresse, Thierry; Conejero, Vicente; Dadami, Elena; Dalakouras, Athanasios; Daròs, José‐Antonio; Peña, Marcos de la; Delgado, Sonia; Serio, Francesco Di; Dixon, J. M.; Durán-Vila, N.; El-Dougdoug, Khaled A.; Elleuch, Amine; Faggioli, F.; Flores, Ricardo; Fraile, Aurora; Gago‐Zachert, Selma; Gallitelli, D.; García‐Arenal, Fernando; Geering, Andrew D. W.; Giunchedi, L.; Gómez, Gustavo; Gyamera, Ebenezer A.; Habili, Nuredin; Hadidi, A.; Hallan, Vipin; Hammond, Rosemarie W.; Hanold, D.; Hataya, Tatsuji; Hernández, Carmen; Hóng, Ní; Hosakawa, Munetaka; Hsu, Yau‐Heiu; Hu, Chung-Chi; Huang, Ying; James, D.; Joseph, Hendry; Kalantidis, Kriton; Kaponi, Maria S.; Kim, Mi-Kyeong; Kinard, Gary; Ling, K. Charles; Kovalskaya, Natalia; Kuhn, David N.; Kyriakopoulou, P. E.; Lavagi, Irene; Li, Shifang; Lin, Na-Sheng; Ling, Kai‐Shu; Liou, Ming-Ru; Lisón, Purificación; López-Carrasco, Amparo; Luigi, M.; Alba, Ángel Emilio Martínez de; Mascia, Tiziana; Masuta, Chikara; Matoušek, Jaroslav; Maurel, Marie-Christine; Meekes, E.T.M.; Minoia, Sofía; Navarro, Beatriz; Nie, Xianzhou; Owens, Robert A.; Pallás, Vicente; Palukaitis, Peter; Parakh, D. B.; Perreault, Jean‐Pierre; Podleckis, E. V.; Pyle, Jesse D.; Randles, J. W.; Riesner, Detlev; Rodriguez, M. J. B.; Roenhorst, J. W.; Roossinck, Marilyn J.; Rubino, Luisa; Sánchez‐Navarro, J. A.; Shimmen, Teruo; Scholthof, Karen‐Beth G.; Serra, P.; Shimura, Hanako; Singh, R. P.; Škorić, Dijana; Stancanelli, Giuseppe; Steger, Gerhard; Taglienti, Anna; Tessitori, M.; Thanarajoo, Sathis Sri; Tiberini, Antonio; Torchetti, Enza Maria; Tsagris, Mina; Tsushima, Takao; Vadamalai, Ganesan; Verhoeven, J. Th. J.; Vidalakis, Georgios; Wang, Qiao‐Chun; Wassenegger, Michael; Winter, Stephan; Xú, Wénxìng; Yang, Xiangdong; Zhang, Yongjiang; Zhang, Zhibo; Zhou, Xueping; Zhu, Shuifang

doi:10.1016/b978-0-12-801498-1.00074-7

Cited by 1 publication

(1 citation statement)

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“…However the lack of altered transcriptional activity in infected plants of MRTCP genes, argues against the possibility that such physiological effects can be associated to HSVd infection in cucumber. No significant correlation was observed when the targets of the other six differentially expressed miRNAs where analyzed evidencing that, in coincidence with the described in other plant-viroid models (27,31,(101)(102)(103), the global effects of HSVd infection in cucumber miRNA metabolisms is weak, and generally not related to an evident regulation of their targets.…”

Section: Discussionmentioning

confidence: 67%

Multiomic analisys reveals that viroid infection induces a temporal reprograming of plant-defence mechanisms at multiple regulatory levels

Marquez‐Molins

Villalba-Bermell

Corell-Sierra

et al. 2022

Preprint

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Constricted by an extreme biological simplicity, viroids are compelled to subvert host regulatory networks in order to accomplish their infectious process. Most of the studies focused on the response to viroid infection have only addressed a specific host regulatory level and considered a unique infection time. Thus, much remains to be done if we want to understand the temporal evolution and complex nature of viroid-host interactions. Here we present an integrative analysis of the timing and intensity of the genome-wide alterations in cucumber plants infected with Hop stunt viroid (HSVd). Differential host transcriptome, sRNAnome and methylome were integrated to determine the temporal response to viroid-infection. Our results support that HSVd promotes a dynamic redesign of the cucumber regulatory pathways predominantly affecting specific regulatory layers at different infection phases. Remarkably, the initial response was characterized by a reconfiguration of the host transcriptome by differential exon usage, followed by a predominant down-regulation of the transcriptional activity possibly modulated by the host epigenetic changes associated to infection and characterized by an increased hypermethylation. The silencing of at least three cucumber transcripts potential targets of vd-sRNAs was also observed. The alteration in host sRNA and miRNA metabolism was marginal. We expect that these data constituting the first comprehensive map of the cucumber-response to HSVd could contribute to elucidate the molecular basis of the host alterations triggered by viroid infection.

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