Listening to Rhythmic Music Reduces Connectivity within the Basal Ganglia and the Reward System

Brodal, Hans Petter; Osnes, Berge; Specht, Karsten

doi:10.3389/fnins.2017.00153

Cited by 20 publications

(14 citation statements)

References 44 publications

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“…However, it is important to note that the direction of the connectivity is not reflected in standard functional connectivity or tractography analyses. Further studies using effective connectivity measures such as dynamic causal modeling (DCM; Friston et al, 2003) are needed to understand better the directionality of such interactions (for an example of the use of DCM to study the interaction among auditory cortex, basal ganglia, and ventral striatum in rhythm perception, see Brodal et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

White Matter Microstructure Reflects Individual Differences in Music Reward Sensitivity

et al. 2019

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People show considerable variability in the degree of pleasure they experience from music. These individual differences in music reward sensitivity are driven by variability in functional connectivity between the nucleus accumbens (NAcc), a key structure of the reward system, and the right superior temporal gyrus (STG). However, it is unknown whether a neuroanatomical basis exists for this variability. We used diffusion tensor imaging and probabilistic tractography to study the relationship between music reward sensitivity and white matter microstructure connecting these two regions via the orbitofrontal cortex (OFC) in 38 healthy human participants (24 females and 14 males). We found that right axial diffusivity (AD) in the STG-OFC connectivity inversely correlated with music reward sensitivity. Additionally, right mean diffusivity and left AD in the NAcc-OFC tract also showed an inverse correlation. Further, AD in this tract also correlated with previously acquired BOLD activity during music listening, but not for a control monetary reward task in the NAcc. Finally, we used mediation analysis to show that AD in the NAcc-OFC tract explains the influence of NAcc activation during a music task on music reward sensitivity. Overall, our results provide further support for the idea that the exchange of information among perceptual, integrative, and reward systems is important for musical pleasure, and that individual differences in the structure of the relevant anatomical connectivity influences the degree to which people are able to derive such pleasure.

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Section: Discussionmentioning

confidence: 99%

White Matter Microstructure Reflects Individual Differences in Music Reward Sensitivity

et al. 2019

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“…Listening to music also showed significant changes in rs-FC of the e-PNN in healthy controls (Karmonik et al, 2016; Brodal et al, 2017; Alluri et al, 2017). However, the connectivity patterns show solely the after effects of listening to music and differ from those identified in the FM patients, starting with a right lateralization of the significant changes, compared to the left lateralization in FM.…”

Section: Discussionmentioning

confidence: 94%

Functional connectivity of music-induced analgesia in fibromyalgia

Pando‐Naude

Barrios

Alcauter

et al. 2017

Preprint

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Listening to self-chosen, pleasant and relaxing music reduces pain in fibromyalgia (FM), a chronic central pain condition. However, the neural correlates of this effect are fairly unknown and could be regarded as a more direct measure of analgesia. In our study, we wished to investigate the neural correlates of music-induced analgesia (MIA) in fibromyalgia patients. To do this, we studied 20 FM patients and 20 matched healthy controls (HC) acquiring rs-fMRI with a 3T MRI scanner, and pain data before and after two 5-min auditory conditions: music and noise. We performed resting state functional connectivity (rs-FC) seed-based correlation analyses (SCA) using pain and analgesia-related ROIs to determine the effects before and after the music intervention in FM and HC, and its correlation with pain reports. We found significant differences in baseline rs-FC between FM and HC. Both groups showed changes in rs-FC in several ROIs after the music condition between different areas, that were left lateralized in FM and right lateralized in HC. FM patients reported MIA that was significantly correlated with rs-FC decrease between the angular gyrus, posterior cingulate cortex and precuneus, and rs-FC increase between amygdala and middle frontal gyrus. These areas are related to autobiographical and limbic processes, and auditory attention, suggesting MIA may arise as a consequence of top-down modulation, probably originated by distraction, relaxation, positive emotion, or a combination of these mechanisms.

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“…This activity is goal oriented and mastering of a goal is a dopamine release factor (Lehrer, 2011). Music listening and production activate the reward circuitry cortical networks in reference to emotional reward, followed by a dopamine release—a neurotransmitter evident in the reward system (Owessen-White et al, 2016; Brodal et al, 2017). Dopamine may be a core factor for increased neuroplasticity during musical training.…”

Section: Discussionmentioning

confidence: 99%

Neuroplastic Effects in Patients With Traumatic Brain Injury After Music-Supported Therapy

Vik

Skeie

Specht

2019

Front. Hum. Neurosci.

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Damage to the orbitofrontal cortex (OFC) often occurs following a traumatic brain injury (TBI) and can lead to complex behavioral changes, including difficulty with attention and concentration. We investigated the effects of musical training on patients with behavioral and cognitive deficits following a mild traumatic brain injury (mTBI) and found significant functional neuro-plastic changes in the OFC’s networks. The results from neuropsychological tests revealed an improved cognitive performance. Moreover, six out of seven participants in this group returned to work post intervention and reported improved well-being and social behavior. In this study, we explore the functional changes in OFC following music-supported intervention in reference to connecting networks that may be responsible for enhanced social interaction. Furthermore, we discuss the factor of dopamine release during playing as an element providing a possible impact on the results. The intervention consisted of playing piano, two sessions per week in 8 weeks, 30 min each time, with an instructor. Additional playing was required with a minimum of 15 min per day at home. Mean time playing piano in reference to participant’s report was 3 h per week during the intervention period. Three groups participated, one mTBI group ( n = 7), two control groups consisting of healthy participants, one with music training ( n = 11), and one baseline group without music training ( n = 12). Participants in the clinical group had received standardized cognitive rehabilitation treatment during hospitalization without recovering from their impairments. The intervention took place 2 years post injury. All participants were assessed with neuropsychological tests and with both task and resting-state functional magnetic resonance imaging (fMRI) pre-post intervention. The results demonstrated a significant improvement of neuropsychological tests in the clinical group, consistent with fMRI results in which there were functional changes in the orbitofrontal networks (OFC). These changes were concordantly seen both in a simple task fMRI but also in resting-state fMRI, which was analyzed with dynamic causal modeling (DCM). We hypothesized that playing piano, as designed in the training protocol, may provide a positive increase in both well-being and social interaction. We suggest that the novelty of the intervention may have clinical relevance for patients with behavioral problems following a TBI.

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Listening to Rhythmic Music Reduces Connectivity within the Basal Ganglia and the Reward System

Cited by 20 publications

References 44 publications

White Matter Microstructure Reflects Individual Differences in Music Reward Sensitivity

White Matter Microstructure Reflects Individual Differences in Music Reward Sensitivity

Functional connectivity of music-induced analgesia in fibromyalgia

Neuroplastic Effects in Patients With Traumatic Brain Injury After Music-Supported Therapy

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