Listeria Brain Abscess in the Acquired Immunodeficiency Syndrome

Harris, Jonathan O.; Márquez, José Luis; Swerdloff, Marc; Magana, Ignacio A.

doi:10.1001/archneur.1989.00520390016005

Cited by 26 publications

(6 citation statements)

References 9 publications

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“…treated with prednisone therapy for autoimmune disease, diabetes mellitus, alcohol abuse, cirrhosis, and AIDS. 42,[46][47][48] A few additional cases were reported to be immunocompetent but did have other medical conditions such as "mild" diabetes mellitus or moderate alcohol use. 46,49 Age does not play a significant role in the development of cerebritis.…”

Section: Predisposing Factors and Clinical Manifestationsmentioning

confidence: 99%

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Listeria and Atypical Presentations of Listeria in the Central Nervous System

Bartt¹

2000

Semin Neurol

103

105

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Listeria monocytogenes infection of the central nervous system is often not recognized and treated appropriately in the crucial early stages of the disease. Most consider patients with underlying disease or immunocompromised states to be at risk, although healthy individuals may present with a neurologic syndrome caused by L. monocytogenes. Earlier suspicion and treatment remains our best means of reducing the morbidity and high mortality rate of this treatable disease. In addition to meningitis and meningoencephalitis, infection of the brainstem (rhomboencephalitis) is challenging to recognize and therefore initiate appropriate early therapy. Cerebritis and abscess can also occur. Furthermore, empirical therapy for meningitis or the other manifestations of nervous system involvement is often inadequate. This review addresses the clinical microbiology, pathogenesis, spectrum of neurological involvement, and treatment of central nervous system infection related to L. monocytogenes.

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Section: Predisposing Factors and Clinical Manifestationsmentioning

confidence: 99%

“…Antibiotic successes have been reported several times without surgical intervention. 32,43,46,48,[50][51][52] Pathologically, there is perivasculitis as described before, and the repeated nonsurgical successes may reflect adequate antibiotic penetration into the infected areas.…”

Section: Treatment and Prognosismentioning

confidence: 99%

Listeria and Atypical Presentations of Listeria in the Central Nervous System

Bartt¹

2000

Semin Neurol

103

105

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“…1 Since then 186 cases of adult listeriosis have been reported in the English literature by 1980. 2 Patients with malignancy, 3 connective tissue disease, 4 those receiving immunosuppressive drugs, 5 patients with AIDS, 6 pregnant women, neonates and the elderly 2 are particularly prone to develop listeriosis. Although meningitis is the usual form of presentation, rhombencephalitis, 7 " 919 brain abscess, 610 and spinal cord abscess 11 " 131718 are increasingly being recognized since the advent of magnetic resonance imaging (MRI).…”

Section: Can J Neurol Sci 1996; 23: 220-223mentioning

confidence: 99%

Listeria Spinal Cord Abscess – Clinical and MRI Findings

Chu

Montanera²,

Willinsky³

1996

Can. j. neurol. sci.

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ABSTRACT:Background: Intramedullary spinal cord abscess due to Listeria Monocytogenes is an uncommon condition usually affecting immunocompromised patients. Method: Case study. Results: A 69-year-old man presented with 3 weeks history of subacute paralysis of both lower limbs and the left upper limb. Myelogram and CT scan showed a widened upper cervical cord. CSF revealed lymphocytosis, moderately elevated protein and depressed glucose. A gadolinium-enhanced MRI showed diffuse cervical cord edema with two ring-enhancing lesions at C2-C3. Blood and CSF cultures grew Listeria Monocytogenes. He received IV ampicillin and gentamycin; the latter was discontinued after 1 month due to nephrotoxicity. Serial MRI over the next 3 months showed significant reduction in the size of these abscesses. The patient made a modest improvement in the power of his lower limbs, however he remained bed-ridden. Aside from being a mild, diet-controlled diabetic, there was no evidence of immunosuppression. Conclusion: Listeria spinal cord abscess is a treatable disorder and should be considered in the differential diagnosis in patients with a subacute onset of spinal cord dysfunction. RESUME: Abces a Listeria de la moelle epiniere: observations cliniques et RMN. Introduction: L'abces intramedullaire du au Listeria monocytogenes est une condition rare qui atteint g6n6ralement les patients immunocompromis. Methode: Etude de cas. Resultats: Un homme ag6 de 69 ans s'est presente avec une histoire de paralysie subaigue des deux membres inferieurs et du membre sup6rieur gauche apparue trois semaines auparavant. Le myelogramme et le CT scan ont montr6 une moelle cervicale haute elargie. Le LCR a montre une lymphocytose, une eleVation modeY6e des proteines et un abaissement du glucose. Une RMN rehaussee au gadolinium a montre un oedeme diffus de la moelle cervicale avec deux lesions rehaussantes en anneaux au niveau de C2-C3. Des cultures du sang et du LCR ont revele la presence de Listeria monocytogenes. Le patient a regu de l'ampicilline et de la gentamycine IV, cette derniere medication ayant ete cessee apres un mois a cause de la n6phrotoxicite. La RMN s6riee sur une periode de 3 mois a montre une diminution significative de la taille de ces abces. La recuperation a ete minime et le patient est demeure' alite. Ce patient avait un diabete 16ger control^ par la diete. II n'avait pas d'evidence d'immunosuppression. Conclusions: L'abces spinal a Listeria est une maladie traitable et devrait etre considere dans le diagnostic diff6rentiel des patients qui ont une dysfonction de la moelle epiniere a d6but subaigu.

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“…C-3), and cultured to definitively categorize the bacteria present. Bacteria seen in CNS samples from HIV-infected patients have been Listeria monocytogenes, 89,90 Nocardia asteroides, 91,92 Salmonella enteritidis, 93 Treponema pallidum, 94,95 and Escherichia coli. 96…”

Section: Bacterial Infectionsmentioning

confidence: 99%

Review of the central nervous system cytopathology in human immunodeficiency virus infection

Strigle

Gal

1991

Diagnostic Cytopathology

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The human immunodeficiency virus (HIV) is a neurotropic retrovirus capable of producing a wide spectrum of central nervous system changes. Nearly 40% of HIV-infected patients demonstrate neuropathy ranging from dementia to the opportunistic infections and neoplasia seen in the acquired immunodeficiency syndrome (AIDS). Dramatic increases in the numbers of AIDS cases have allowed for the cytotechnologist and cytopathologist to become acquainted with the various pathologic manifestations of HIV infection. In this review, we are reporting the HIV-related diseases in the central nervous system and the role of diagnostic cytology.

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Listeria Brain Abscess in the Acquired Immunodeficiency Syndrome

Cited by 26 publications

References 9 publications

Listeria and Atypical Presentations of Listeria in the Central Nervous System

Listeria and Atypical Presentations of Listeria in the Central Nervous System

Listeria Spinal Cord Abscess – Clinical and MRI Findings

Review of the central nervous system cytopathology in human immunodeficiency virus infection

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