Listeria Infection in Transplant Patients

Ascher, Nancy L.

doi:10.1001/archsurg.1978.01370130092018

Cited by 32 publications

(2 citation statements)

References 27 publications

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“…Moreover, despite the observation that food has often been the vehicle of transmission, gastroenteris is an infrequent presentation. Nonetheless, gastrointestinal symptoms before the onset of meningitis or other invasive diseases due to L. monocytogenes have been reported in both sporadic [17][18][19] and outbreak-associated cases [20][21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

A foodborne outbreak of gastroenteritis involvingListeria monocytogenes

Donné²,

et al. 1996

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An outbreak of gastroenteritis occurred in Italy among 39 persons who had attended a private supper. All guests were previously healthy, young, non-pregnant adults; 18 (46%) had symptoms, mostly gastrointestinal (78%), with a short incubation period. Four were hospitalized with acute febrile gastroenteritis, two of whom had blood cultures positive for Listeria monocytogenes. No other microorganisms were recovered from the hospitalized patients' specimens. Epidemiological investigation identified rice salad as the most likely vehicle of the food-borne outbreak. L. monocytogenes was isolated from three leftover foods, the kitchen freezer and blender. Isolates from the patients, the foods and the freezer were indistinguishable: serotype 1/2b, same phage type and multilocus enzyme electrophoretic type. Eight (36%) of 22 guests tested were found to have antibodies against L. monocytogenes, compared with none of 11 controls from the general population. This point source outbreak was probably caused by infection with L. monocytogenes. Unusual features included the high attack rate among immunocompetent adults and the predominance of gastrointestinal symptoms.

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Section: Discussionmentioning

confidence: 99%

A foodborne outbreak of gastroenteritis involvingListeria monocytogenes

Donné²,

et al. 1996

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“…Sulfisoxazole is often used as a prophylactic antibacterial agent in renal transplant patients to reduce the likelihood of urinary tract infections during the postoperative recovery phase (2). Sulfisoxazole has been safely used in this patient population in a number of institutions including our own (3,6).…”

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Pharmacokinetics of sulfisoxazole in renal transplant patients

Shermantine¹,

Gambertoglio²,

Amend³

et al. 1985

Antimicrob Agents Chemother

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We studied the elimination of sulfisoxazole in eight renal transplant patients. The patients received sulfisoxazole prophylactically for urinary tract infection commencing 7 days postoperatively. The renal elimination of sulfisoxazole (unbound renal clearance) was decreased in this patient population and was highly correlated with creatinine clearance. The unbound metabolic clearance and apparent unbound formation clearance of N4-acetyl sulfisoxazole did not differ from values found in healthy volunteers. The protein binding was marginally lower in this patient population than in healthy subjects after a single dose. The reduced binding was compatible with a reduced albumin concentration. In contrast to the situation for healthy subjects, the binding of sulfisoxazole decreased upon multiple dosing. This is probably due to a relatively higher sulfisoxazole and N4-acetyl sulfisoxazole-to-albumin ratio in this patient population than in healthy subjects. No complications of sulfisoxazole therapy were seen, although in three subjects concentration of the N4-acetyl sulfisoxazole in urine exceeded its theoretical solubility on a few occasions.

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