2017
DOI: 10.1128/iai.00733-16
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Listeria monocytogenes-Induced Cell Death Inhibits the Generation of Cell-Mediated Immunity

Abstract: The influence of cell death on adaptive immunity has been studied for decades. Despite these efforts, the intricacies of how various cell death pathways shape immune responses in the context of infection remain unclear, particularly with regard to more recently discovered pathways such as pyroptosis. The emergence of Listeria monocytogenes as a promising immunotherapeutic platform demands a thorough understanding of how cell death induced in the context of infection influences the generation of CD8 ϩ T-cell-me… Show more

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Cited by 27 publications
(34 citation statements)
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“…In some cases, excessive inflammasome activation or pyroptosis is detrimental to the host. Unchecked inflammasome activation can either drive immunopathology in response to infection by Pseudomonas aeruginosa (117, 118) or impair the generation of CD8 + T-cell-mediated immunity to Listeria monocytogenes (119). …”
Section: Introductionmentioning
confidence: 99%
“…In some cases, excessive inflammasome activation or pyroptosis is detrimental to the host. Unchecked inflammasome activation can either drive immunopathology in response to infection by Pseudomonas aeruginosa (117, 118) or impair the generation of CD8 + T-cell-mediated immunity to Listeria monocytogenes (119). …”
Section: Introductionmentioning
confidence: 99%
“…Some forms of cell death are thought to inhibit the generation of protective immunity. Strains of L. monocytogenes engineered to induce pyroptosis, necrosis or apoptosis inhibit the generation of protective immunity [26]. Thus, it is likely that LLO-induced cell death also affects the immune response to L. monocytogenes infection.…”
Section: Insights Into the Effects Of Llo During Infectionmentioning
confidence: 99%
“…In contrast, in the context of L. monocytogenes immunization, necrosis inhibits optimal T-cell priming and, ultimately, protective immunity. Immunization with a strain of L. monocytogenes engineered to express mis-regulated LLO led to decreased primary and recall CD8+ T-cell responses [ 39 ]. Consistent with necrosis being an inflammatory process, however, L. monocytogenes -induced necrosis was able to boost immunity induced by primary dendritic cell immunization [ 39 ].…”
Section: Necrosis and Necroptosismentioning
confidence: 99%
“…Immunization with a strain of L. monocytogenes engineered to express mis-regulated LLO led to decreased primary and recall CD8+ T-cell responses [ 39 ]. Consistent with necrosis being an inflammatory process, however, L. monocytogenes -induced necrosis was able to boost immunity induced by primary dendritic cell immunization [ 39 ]. The mechanism by which necrosis impairs L. monocytogenes stimulated cell-mediated immunity is incompletely understood, though Theisen et al suggested that hyperactivation of necrosis led to both a loss of cross-presenting dendritic cells as well as suboptimal expression of costimulatory molecules [ 39 ].…”
Section: Necrosis and Necroptosismentioning
confidence: 99%
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