Listeria monocytogenes infection in prosthetic joints

Allerberger, Franz; Kasten, Mary J.; Cockerill, Franklin R.; Krismer, Martin; Dierich, Manfred P.

doi:10.1007/bf00182702

Cited by 35 publications

(31 citation statements)

References 18 publications

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“…Listeriosis is very rarely seen in im wkw 3-4/2009 Epidemiology of listeriosis in Austria review article 114 munocompetent adults and then usually presents as an illness with diarrhea and selflimiting, flulike symp toms. It may also manifest as a local infection such as conjunctivitis or cholecystitis [2][3][4]. However, in immu nocompromised patients it presents as a lifethreaten ing illness, especially as sepsis or meningitis.…”

Section: Introductionmentioning

confidence: 98%

Epidemiology of listeriosis in Austria

Kasper

Huhulescu

Auer

et al. 2009

Wien Klin Wochenschr

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A total of 150 human cases of listeriosis (case definition based on isolation of Listeria monocytogenes from normally sterile material) were reported in Austria between 1997 and 2007. Of these, 14 cases (9.3%) were pregnancy-associated (mother/child illness considered as a single case) with a mean age of 29.3 years (median: 26.5; range 24-36). Among the non-pregnancy-associated cases (n = 136), 75 were male (55.2%) and 61 female (44.9%); patients in this group had a mean age of 64.3 years (median: 66.2; range 1-93). The average incidence of listeriosis in Austria in the period studied was 0.168 cases per 100,000 population. The majority of cases (90.7%) were caused by systemic infection, only 9.3% of cases were local infections. Among non-pregnancy-associated cases the fatality rate was 28.7% (39/136) and among the pregnancy-associated cases 35.7% (5/14: miscarriage x3, stillbirth x1, and one death in a newborn within 15 days of birth). Serotyping results for the 150 isolates revealed serovar (SV) 4b: 54%, SV 1/2a: 31.3%, SV 1/2b: 10%, SV 1/2c: 2.7%, 4d: 1.3% and SV 3a: 0.7%. Predisposing risk factors were determined for 131 of the 150 cases: age > or = 65 years (n = 73), pregnancy (n = 14) and 44 cases of carcinoma, blood malignancies, autoimmune diseases and status post solid organ transplants (7 patients had more than one underlying illness). During the period studied, the incidence of listeriosis doubled, despite a drastic reduction in the frequency of pregnancy-associated cases.

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Section: Introductionmentioning

confidence: 98%

Epidemiology of listeriosis in Austria

Kasper

Huhulescu

Auer

et al. 2009

Wien Klin Wochenschr

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“…Gauto et al [30] and Cone et al [31 ] stated that cephalosporins were 'probably' ineffective against Listeria but thought that these antibiotics might be used. Animal test ing, however, and reports of therapeutic fail ures prove that cephalosporins are not indi cated in the treatment of listeriosis [26,[32][33][34],…”

Section: In Vitro Susceptibility Of Listeria Monocytogenesmentioning

confidence: 99%

In vitro Susceptibility of <i>Listeria monocytogenes</i>: Comparison of the E Test with the Agar Dilution Test

Heger

Dierich

Allerberger³

1997

Chemotherapy

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In vitro susceptibility testing was performed on 66 strains of Listeria monocytogenes. Recently obtained clinical isolates from Austria, France, Norway and Switzerland and 17 reference strains from three type culture collections were tested against ampicillin, gentamicin, trimethoprim-sulfamethoxazole, ampicillin-sulbactam, meropenem, and first-, second-, third- and fourth-generation cephalosporins. All isolates were susceptible to ampicillin, gentamicin, and trimethoprim-sulfamethoxazole, ampicillin-sulbactam, and meropenem and more than 86% of the minimal inhibitory concentration E test values were within plus/minus one dilution step of the agar dilution test. In vitro susceptibility of L. monocytogenes has not changed markedly during the last decades; the level of susceptibility of old reference strains did not differ from that of recently encountered clinical isolates. The E test seems to be a suitable method for Listeria.

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“…monocytogenes bacteremia might precede meningeal spread; however, at this stage it seems to already affect the CNS and manifests with symptomatic illness [16][17][18][19][20]. When diagnosed at this early stage the prognosis of the disease can be significantly improved with promptly delivered specific therapy.…”

Section: Discussionmentioning

confidence: 95%