Listeria monocytogenes meningitis in the elderly: Distinctive characteristics of the clinical and laboratory presentation

Pagliano, Pasquale; Attanasio, Vittorio; Rossi, Marco; Carleo, Maria Aurora; Carannante, Novella; Ascione, Tiziana; Tuccillo, Francesco; Fraganza, Fiorentino

doi:10.1016/j.jinf.2015.02.003

Cited by 24 publications

(24 citation statements)

References 11 publications

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“…Contrary to the present results, a previous study in Italy has demonstrated that an unfavorable outcome frequently occurred for those patients presenting a low WBC count. 30 Human neurolisteriosis is a bloodborne infection and positive blood cultures at the time of diagnosis can not only reflect higher circulating bacteria in the blood as well as weaker host defenses, but also a higher risk of mortality due to other opportunistic infections. 5 In our study, an elderly patient with positive blood and CSF cultures was not cured at discharge.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Laboratory Characteristics of Patients infected by Listeria monocytogenes at a Tertiary Hospital in Hefei City, China

Shi¹,

Lv²,

Zhou³

et al. 2021

IDR

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Background Human listeriosis is a severe foodborne infection caused by Listeria monocytogenes and the data of patients with this infection are largely limited for the Hefei population. Purpose This is a retrospective study that evaluated the clinical and laboratory data of patients with listeriosis at a tertiary hospital in Hefei City. Patients and Methods A total of 24 listeriosis patients were admitted to the First Affiliated Hospital of Anhui Medical University from January 2003 to July 2021. Data from all patients were collected from the hospital’s electronic medical records. Results The most common symptom of all patients was fever (91.7%), followed by altered consciousness (50.0%), rashes (45.8%), respiratory distress symptoms (37.5%), nuchal rigidity (29.2%), and headaches (20.8%). Laboratory results also indicated elevated C-reactive protein (CRP) (79.1%), hypoproteinemia (75.0%), anemia (62.5%), leukocytosis (45.8%), and neutrophilia (45.8%). The mean value of 5.1 μg/mL (SD, 3.8) for D‐dimer (D‐D) was significantly higher than the normal value ((0.00–0.50) μg/mL), while both altered consciousness (6 vs 4, P = 0.034) and headaches (4 vs 1, P = 0.036) occurred more frequently in the neurolisteriosis group compared with the bacteremia one. Additionally, the mean maximal body temperature (°C) (40.5 ± 0.7) as well as white blood cell (WBC) (15.3 vs 7.5 ×10 9 /L, P = 0.014) and neutrophil (NEUT#) (13.2 vs 6.1 ×10 9 /L, P = 0.026) counts of neurolisteriosis patients were higher than those of bacteremia (39.4 ± 0.4) ( P = 0.001). Of all patients, four (50%) from the maternal-neonatal group remained uncured. Conclusion Listeriosis is a rare disease with extremely variable clinical characteristics in Hefei City. Our data indicated that unexplained fever, altered consciousness, hypoproteinemia, anemia, elevated CRP and DD should be considered to assist diagnosis of listeriosis for early treatment interventions.

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Section: Discussionmentioning

confidence: 99%

Clinical and Laboratory Characteristics of Patients infected by Listeria monocytogenes at a Tertiary Hospital in Hefei City, China

Shi¹,

Lv²,

Zhou³

et al. 2021

IDR

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“…In addition, in contrast to pneumococcal meningitis, L. monocytogenes meningitis is often detected in people in a coma who did not develop respiratory failure rapidly. Nevertheless, the symptoms and signs of L. monocytogenes meningitis lack specificity or sensitivity [2,22].…”

Section: Clinical Presentationmentioning

confidence: 99%

Brainstem Encephalitis Caused by Listeria monocytogenes

2020

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International outbreaks of listerial infections have become more frequent in recent years. Listeria monocytogenes, which usually contaminates food, can cause potentially fatal infections. Listerial cerebritis is a rare disease that is encountered mostly in immunocompromised or elderly patients. However, listerial brainstem encephalitis (mesenrhombencephalitis or rhombencephalitis) is found in persons who were formerly in good health, and recognizing this disease, particularly at its early stages, is challenging. Listerial brainstem encephalitis has high mortality, and serious sequelae are frequently reported in survivors. Early recognition and correct diagnosis, as well as the timely use of appropriate antibiotics, can reduce the severity of listerial infections. The trigeminal nerve is proposed as a pathway through which L. monocytogenes reaches the brainstem after entering damaged oropharyngeal mucosa or periodontal tissues. This review introduces the clinical manifestations, pathology, magnetic resonance imaging (MRI) findings, diagnosis, and treatment of listerial brainstem encephalitis. Moreover, it proposes that L. monocytogenes may also invade the brainstem along the vagus nerve after it infects enteric neurons in the walls of the gastrointestinal tract.

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“…WNV transmission through organ transplantation was first described during the 2002 epidemic [9]. This can be a relevant aspect as organ transplant recipients who are chronically immunosuppressed appear to have an increased risk for severe WNV disease, regardless of the transmission route, as it is generally reported in immunocompromised and elderly with CNS infections [10][11][12][13][14].…”

Section: Non-mosquito-borne Transmissionmentioning

confidence: 99%

West Nile Virus diffusion in temperate regions and climate change. A systematic review

et al. 2023

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Listeria monocytogenes meningitis in the elderly: Distinctive characteristics of the clinical and laboratory presentation

Cited by 24 publications

References 11 publications

Clinical and Laboratory Characteristics of Patients infected by Listeria monocytogenes at a Tertiary Hospital in Hefei City, China

Clinical and Laboratory Characteristics of Patients infected by Listeria monocytogenes at a Tertiary Hospital in Hefei City, China

Brainstem Encephalitis Caused by Listeria monocytogenes

West Nile Virus diffusion in temperate regions and climate change. A systematic review

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