Listeria monocytogenes septic arthritis in a patient treated with mycophenolate mofetil for polyarteritis nodosa: a case report and review of the literature

Pozo, J.L. del; Garza, Rocío García de la; Rada, P. Díaz de; Ornilla, Enrique; Yuste, José Ramón

doi:10.1016/j.ijid.2012.11.005

Cited by 20 publications

(10 citation statements)

References 6 publications

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“…A variety of cases of infectious complication in patients treated with azathioprine and mycophenolate mofetil have been published. Bacterial infections (common and atypical bacterial infections including Listeria monocytogenes , and mycobacterium species), fungal infections ( Cryptococcus neoformans, Aspergillus , Mucor , Pneumocystis jirovecii ), parasitic infection/reactivation ( Toxoplasma gondii ), and viral infection/reactivation (disseminated herpes zoster, varicella reactivation, JC virus, and polyomavirus associated nephropathy associated with BK virus infection) have been reported in azathioprine and mycophenolate mofetil users . The FDA places a special emphasis on the risk of JC virus‐associated progressive multifocal leukoencephalopathy in azathioprine and mycophenolate mofetil users .…”

Section: Other Immunosuppressive Drugsmentioning

confidence: 99%

Preventing infectious complications when treating non‐malignant immune‐mediated hematologic disorders

2019

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Immunosuppressants, targeted antibody therapies, and surgical splenectomy are amongst the treatment choices for immune-mediated non-malignant hematologic disorders, with infection being the most common non-hematological adverse event from these therapies. Corticosteroids are associated with a length-of-treatment and dose-dependent risk for infection, including opportunistic infections. Screening and antimicrobial prophylaxis against tuberculosis, Strongyloides stercoralis, and Pneumocystis jirovecii pneumonia, are indicated in selected patients on steroids and with certain risk factors for infection. Rituximab is associated with hepatitis B virus reactivation. All patients planned to be started on rituximab should be screened for hepatitis B surface antigen and total core antibody, with antiviral prophylaxis given depending on test results. In eculizumab treated patients, immunization against meningococcal serogroups ACWY and B is recommended. In addition, some guidelines suggest antibiotic prophylaxis for the duration of eculizumab treatment. In splenectomized patients, counseling and immunization are cornerstones of infection prevention. Several federal and society guidelines about immunizations and prophylactic antimicrobial therapies for patients treated with various immunosuppressive agents exist and are summarized in this manuscript in a clinical-focused table. In addition, management suggestions are made where no formal guidelines exist. 2 | PATIENT COUNSELING An important part of infectious disease prevention in immunocompromised patients entails the education of the patient, family, and friends. Household and other close contacts of persons with altered immunocompetence should be educated in hand hygiene and avoid contact with the patient when they are experiencing an infectious process. 12 Proper food and water hygiene measures are important to prevent

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Section: Other Immunosuppressive Drugsmentioning

confidence: 99%

Preventing infectious complications when treating non‐malignant immune‐mediated hematologic disorders

2019

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“…Listeriosis is a serious foodborne disease caused by Listeria monocytogenes , predominantly affecting people with weakened immune systems including neonates, pregnant women, elderly and immunocompromised individuals leading to serious illness with high mortality rates ( European Food Safety Authority [EFSA], 2017 ; Centers for Disease Control [CDC], 2018 ; Radoshevich and Cossart, 2018 ). Although infections usually manifest as meningitis, bacteremia, and feto-maternal complications, listeriosis can in rare cases present as focal infections in different organs including bone and joint ( Allerberger and Wagner, 2010 ; Del Pozo et al, 2013 ; Chavada et al, 2014 ; European Food Safety Authority [EFSA], 2017 ; Radoshevich and Cossart, 2018 ). Septic arthritis is one of infrequent listeriosis manifestation that usually involves orthopedic implant devices and it is more common in older or immunosuppressed individuals ( Cone et al, 2001 ; Chougle and Narayanaswamy, 2004 ; Kesteman et al, 2007 ; Charlier et al, 2012 ; Del Pozo et al, 2013 ; Chavada et al, 2014 ; Bush et al, 2015 ; Bader et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Evolution of Listeria monocytogenes During a Persistent Human Prosthetic Hip Joint Infection

Muchaamba

Eshwar

et al. 2020

Front. Microbiol.

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“…Additional high-risk populations include those with hematologic malignancy, end-stage renal disease, AIDS, organ transplantation, iron-overload states, alcoholism and other chronic liver diseases [ 3 , 8 ]. In particular, the risk of invasive Listeriosis is noted with the use of TNF-α inhibitors as it suppresses T-cell mediated immunity; the primary defence against this organism [ 10 – 12 ].…”

Section: Discussionmentioning

confidence: 99%

Listeria spondylodiscitis: an uncommon etiology of a common condition; a case report

et al. 2020

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Background Listeriosis is a severe food-borne infection caused by the Gram-positive rod, Listeria monocytogenes. Despite the low incidence (3–8 cases per million), Listeriosis has a case fatality rate of 20–30% as it occurs predominantly in immunocompromised individuals at extremes of age, diabetics and pregnant women. Listeriosis classically presents as a febrile gastroenteritis, isolated bacteremia, meningitis, or maternal-fetal infections. Focal bone and joint infection are rare and primarily involve orthopedic implant devices. Here, we present the first case of Listeria-associated spondylodiscitis. Case presentation A 79-year-old male presents with acute-on-chronic back pain in the absence of risk factors or exposures, aside from age. On radiological imaging, spondylodiscitis of L3-L4 was diagnosed. Subsequently, a CT-guided biopsy was performed to aid in confirming microbiological aetiology. Listeria monocytogenes was grown in culture and patient received appropriate antibacterial therapy. Conclusion The case highlights the utility of image-guided tissue sampling in aiding diagnosis and management in patients with vertebral osteomyelitis. It also encourages consideration of uncommon organisms such as Listeria as an etiology of vertebral osteomyelitis, even in the absence of prosthetic implants.

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Listeria monocytogenes septic arthritis in a patient treated with mycophenolate mofetil for polyarteritis nodosa: a case report and review of the literature

Cited by 20 publications

References 6 publications

Preventing infectious complications when treating non‐malignant immune‐mediated hematologic disorders

Preventing infectious complications when treating non‐malignant immune‐mediated hematologic disorders

Evolution of Listeria monocytogenes During a Persistent Human Prosthetic Hip Joint Infection

Listeria spondylodiscitis: an uncommon etiology of a common condition; a case report

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