Listeriosis During Pregnancy and in Newborns: 18 Years of Data From a Large Tertiary Hospital in Singapore

Abstract

A 20-year retrospective review at a tertiary hospital in Singapore identified 11 cases of perinatal listeriosis in maternal–fetal pairs (incidence, 4.8 cases per 100 000 live births). Fever, meconium-stained amniotic fluid, and fetal akinesia during the third trimester were associated with listeriosis. In this study early directed antibiotic therapy resulted in favorable outcomes.

Atypical presentation of listeriosis in pregnancy: A case report and review of the literature

“…The majority of the cases are Chinese (54%), as they constitute the main population in Singapore, followed by other races such as Indian, Malaysian and Indonesian. 5 The rate is higher than that in the UK (4.0 cases per 100,000 live births) and the USA (3.48 cases per 100,000 live births). 5…”

“…5 The rate is higher than that in the UK (4.0 cases per 100,000 live births) and the USA (3.48 cases per 100,000 live births). 5…”

“…1,2,6 The most common clinical presentations for neonatal listeriosis (NL) are septicaemia (81–88%), respiratory distress (38%) and meningitis (24%). 5 Cutaneous eruptions such as papules, pustules, vesicles or ulcers, endocarditis and multiple abscesses are infrequent symptoms of NL. 5 Other presentations include granulomatosis infantiseptica – a severe form of NL manifest with widespread microabscesses, miliary granulomas, area of necrosis and liver involvement.…”

“…5 Other presentations include granulomatosis infantiseptica – a severe form of NL manifest with widespread microabscesses, miliary granulomas, area of necrosis and liver involvement. 5…”

“…Maternal listeriosis usually presents with fever associated with flu-like illness (100%), reduced foetal movements (45%), preterm labor (36%) and diarrhoea (18%). 5 L. monocytogenes bacteraemia rarely presented with hepatic involvement. However, there are a few reports in the literature of hepatic involvement in adult listeriosis.…”