Listeriosis During Pregnancy

Mylonakis, Eleftherios; Paliou, Maria; Hohmann, Elizabeth L.; Calderwood, Stephen B.; Wing, Edward J.

doi:10.1097/00005792-200207000-00002

Cited by 305 publications

(130 citation statements)

References 102 publications

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“…Case 2 presented a preterm delivery threat and case 3 had urinary symptoms, vomiting and back pain. All of these symptoms have been described in the medical literature (4,6,7). Case 3, a twin pregnancy, also had a discordant infection, as has been described (1).…”

Section: Clinical Presentationmentioning

confidence: 91%

“…Other contamination sources have been reported as cantaloupe, hot dogs, sushi rolls, and meat pates. Most cases are sporadic and others are associated with an outbreak (1,3,4,5).…”

Section: Introductionmentioning

confidence: 99%

“…According to the largest series revised from Mylonakis et al (4), from 191 cases, most of them had fever (65%), flu like symptoms (32%), abdominal or back pain (21.5%), headache (10%), vomiting/diarrhea (7%), minor complaints could be myalgia and sore throat but there are asymptomatic patients in 29%. The effect over the fetus is serious; the infection produces miscarriages, preterm births, impaired fetal growth and fetal death.…”

Section: Introductionmentioning

confidence: 99%

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Listeriosis in pregnancy

Díaz-Herrera¹,

Salvador-Pichilingue²,

Maguiña-Vargas³

et al. 2017

Rev Med Hered

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Section: Clinical Presentationmentioning

confidence: 91%

“…Other contamination sources have been reported as cantaloupe, hot dogs, sushi rolls, and meat pates. Most cases are sporadic and others are associated with an outbreak (1,3,4,5).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Listeriosis in pregnancy

Díaz-Herrera¹,

Salvador-Pichilingue²,

Maguiña-Vargas³

et al. 2017

Rev Med Hered

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“…At-risk individuals include the elderly, persons who are immunocompromised or immunosuppressed, and the fetuses of pregnant women, with one in six listeriosis cases (17%) occurring during pregnancy (3). The risk to a fetus of miscarriage, stillbirth, or premature delivery or of serious illness in a neonate (e.g., septicemia or meningitis) greatly increases if its mother has been exposed to L. monocytogenes (4), though she herself may experience only mild flu-like symptoms (5). One review of historical data (4) reported that 36 of 178 maternal listeriosis cases (20.2%) resulted in spontaneous abortion or stillbirth.…”

mentioning

confidence: 99%

“…The risk to a fetus of miscarriage, stillbirth, or premature delivery or of serious illness in a neonate (e.g., septicemia or meningitis) greatly increases if its mother has been exposed to L. monocytogenes (4), though she herself may experience only mild flu-like symptoms (5). One review of historical data (4) reported that 36 of 178 maternal listeriosis cases (20.2%) resulted in spontaneous abortion or stillbirth. Of the remaining 142 cases, 97 neonates (68.3%) were born with the infection.…”

mentioning

confidence: 99%

Dose Response of Listeria monocytogenes Invasion, Fetal Morbidity, and Fetal Mortality after Oral Challenge in Pregnant and Nonpregnant Mongolian Gerbils

et al. 2014

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Listeria monocytogenes is a food-borne pathogen that can result in adverse pregnancy outcomes, such as stillbirth or premature delivery. The Mongolian gerbil was recently proposed as the most appropriate small-animal model of listeriosis due to its susceptibility to the same invasion pathways as humans. The objectives of this study were to investigate invasion and adverse pregnancy outcomes in gerbils orally exposed to L. monocytogenes, to compare the dose-response data to those of other animal models, and to investigate differences in the responses of pregnant versus nonpregnant gerbils. Gerbils were orally exposed to 0 (control), 10 3 , 10 5 , 10 7 , or 10 9 CFU L. monocytogenes in whipping cream. L. monocytogenes was recovered in a dose-dependent manner from fecal samples, adult organs, and pregnancy-associated tissues. Dams exposed to 10 9 CFU had more invaded organs and higher concentrations of L. monocytogenes in almost all organs than nonpregnant animals, though no differences in fecal shedding were seen between the two groups. Adverse pregnancy outcomes occurred only in the dams treated with 10 9 CFU. A 50% infectivity dose (ID 50 ) of 2.60 ؋ 10 6 CFU for fetuses was calculated by fitting the data to a logistic model. Our results suggest that the 50% lethal dose (LD 50 ) falls within the range of 5 ؋ 10 6 to 5 ؋ 10 8 CFU. This range includes the guinea pig and nonhuman primate LD 50 s, but the observation that L. monocytogenes-induced stillbirths can be seen in guinea pigs and primates exposed to lower doses than those at which stillbirths were seen in gerbils indicates that gerbils are not more sensitive to L. monocytogenes invasion.

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