Litchi thaumatin-like protein induced the liver inflammation and altered the gut microbiota community structure in mice

Wang, Kun; Li, Weichao; Wang, Kai; Du, Bing; Hu, Zhuoyan; Zhao, Lei

doi:10.1016/j.foodres.2022.111868

Cited by 12 publications

(11 citation statements)

References 48 publications

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“…Turicibacter can alleviate inflammation, 43 Bifidobacterium can promote intestinal sIgA secretion, 44 and norank_f_Muribaculaceae negatively correlate with inflammatory cytokine levels. 48 Gentisic acid and 2-isopropylmalic acid also have antioxidant and antibacterial properties. 49,50 In this experiment, LTA maintained immune balance by modulating potentially beneficial microbial communities and amino acid and lipid metabolites.…”

Section: Discussionmentioning

confidence: 99%

“…Gut microbiota and gut metabolites can regulate the balance of the intestinal immune system. Turicibacter can alleviate inflammation, 43 Bifidobacterium can promote intestinal sIgA secretion, 44 and norank_f_Muribaculaceae negatively correlate with inflammatory cytokine levels 48 . Gentisic acid and 2‐isopropylmalic acid also have antioxidant and antibacterial properties 49,50 .…”

Section: Discussionmentioning

confidence: 99%

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L‐Theanine alleviates heat stress through modulation of gut microbiota and immunity

Liu,

Wang,

Lin

et al. 2023

J Sci Food Agric

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BACKGROUNDHeat stress (HS) damages the intestines, disrupting gut microbiota and immune balance. l‐Theanine (LTA), found in tea, alleviates oxidative stress and cell apoptosis under HS; however, its effects on gut microbiota and immunity under HS remain unclear. To investigate this, we administered LTA doses of 100, 200, and 400 mg·kg−1·d−1 to C57BL/6J mice. On day 44, the model group and LTA intervention group were subjected to continuous 7‐day HS treatment for 2 h per day.RESULTSThe results demonstrated that LTA intervention improved food intake, body weight, and intestinal epithelium, and reduced the water intake of heat‐stressed mice. It increased the abundance of Turicibacter, Faecalibaculum, Bifidobacterium, and norank_f_Muribaculaceae, while reducing that of Lachnoclostridium and Desulfovibrio. LTA intervention also increased the concentrations of amino acid and lipid metabolites, regulated macrophage differentiation stimulated by gut microbiota and metabolites, reduced the antigen presentation by macrophages to the specific immune system, promoted B‐cell differentiation and sIgA secretion, inhibited pro‐inflammatory factors, and enhanced intestinal defense. Mechanistically, LTA downregulated heat shock protein 70 expression and the TLR4/NF‐κB/p38 MAPK signaling pathway, restoring gut microbiota and immune balance.CONCLUSIONWe suggest that LTA can alleviate HS by modulating gut microbiota, metabolites, and immunity, indicating its potential as a natural active ingredient for anti‐HS food products. © 2023 Society of Chemical Industry.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

L‐Theanine alleviates heat stress through modulation of gut microbiota and immunity

Liu,

Wang,

Lin

et al. 2023

J Sci Food Agric

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“…† LcTLP was isolated from the litchi pulp and characterized following the method of our previous study. 2,3 2.3. Animal experiments 2.3.1.…”

Section: Preparation Of the Lge And Lctlpmentioning

confidence: 99%

“…It has been reported that intragastric administration of LcTLP induces liver inflammation. 3 Therefore, histology analysis was performed by H&E and immunohistochemical staining (CD4 + and CD8 + ). As shown in Fig.…”

Section: Effects Of Lge On Liver Histologymentioning

confidence: 99%

“…2 With further research, it has been found that in mice that had received LcTLP the liver is prone to suffering from inflammatory reactions. 3 Liver injury is closely linked to the compo-sition of gut microbiota, due to its bidirectional relationship mediated by the 'gut-liver axis'. 4 Dysbiosis in the gut microbiota composition is a typical characteristic in multiple liver diseases, including non-alcoholic fatty liver disease (NAFLD), fibrosis, and cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

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Litchi pulp-derived gamma-aminobutyric acid (GABA) extract counteracts liver inflammation induced by litchi thaumatin-like protein

Wang,

Wang

et al. 2024

Food Funct.

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Broad bean (Vicia faba L.) caused abnormal lipid metabolism in grass carp (Ctenopharyngodon idellus) liver: Insight from the gut microbiota–liver axis

Fu,

Ma,

Yang

et al. 2024

Food Frontiers

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Broad bean (Vicia faba L.) has received attention from the food and animal feed industries as a sustainable, inexpensive, and versatile plant‐based protein source. However, long‐term consumption of broad bean, especially unprocessed ones, can lead to hepatic lipid accumulation. To investigate how broad bean affected hepatic lipid metabolism and its underlying mechanisms, we conducted a multi‐omics analysis of crisp grass carp (Ctenopharyngodon idellus C. et V) model with hepatic steatosis after feeding with single broad bean for 120 days. The glycolysis inhibition, increased de novo lipogenesis, abnormalities in lipid metabolism, and activation of oxidative stress were the key processes involved in broad bean‐induced hepatic lipid accumulation. Disturbances in intestinal flora caused by damage to the intestinal barrier and increased lipopolysaccharide caused by broad bean promoted hepatic lipid accumulation. Reduction of antinutritional factors and balanced diet offer potential strategies to mitigate the liver damage caused by broad bean consumption. Overall, our findings provided a theoretical basis for the wide application of broad bean as animal feeds.

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Litchi thaumatin-like protein induced the liver inflammation and altered the gut microbiota community structure in mice

Cited by 12 publications

References 48 publications

L‐Theanine alleviates heat stress through modulation of gut microbiota and immunity

L‐Theanine alleviates heat stress through modulation of gut microbiota and immunity

Litchi pulp-derived gamma-aminobutyric acid (GABA) extract counteracts liver inflammation induced by litchi thaumatin-like protein

Broad bean (Vicia faba L.) caused abnormal lipid metabolism in grass carp (Ctenopharyngodon idellus) liver: Insight from the gut microbiota–liver axis

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