Literacy and Language in East Asia

Kell, Marilyn; Kell, Peter

doi:10.1007/978-981-4451-30-7

Cited by 9 publications

(3 citation statements)

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“…17 Nevertheless, the efflux and influx effects can still be present or not completely eliminated for a number of permeants due to the presence of multiple transporters. In fact, the vast majority of drugs included in our data set can interact with a variety of influx and efflux transporters 8 (see pages for individual molecules in the PerMM database). The possible effect of influx transporters is expected to result in a higher permeability of polar permeants than that predicted from passive diffusion.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6] In natural membranes, mechanisms of selective permeability are more complex: in addition to passive transbilayer diffusion and diffusion through aqueous boundary layer, there are compound-specific transporter-and carrier-mediated influx and efflux, adsorptive transcytosis of cationic compounds, receptor-mediated endocytosis, micropinocytosis, and other mechanisms. 2,[7][8][9] The relevance of the passive diffusion and transport-mediated influx and efflux of drug-related compounds has been extensively discussed, 1,8,[10][11][12][13] and it was concluded that both mechanisms coexist and contribute to translocation across biological membranes. 1,10 However, rigorous evaluation of the contribution of passive diffusion in vivo is a challenging task, as the measurable permeation of drugs across biological membranes depends on many factors, such as physicochemical properties of drugs (molecular weight, polarity, lipophilicity, hydrogen bonding capacity, charge, etc.)…”

Section: Introductionmentioning

confidence: 99%

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Physics-Based Method for Modeling Passive Membrane Permeability and Translocation Pathways of Bioactive Molecules

Lomize

Pogozheva

2019

J. Chem. Inf. Model.

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Assessment of permeability is a critical step in the drug development process for selection of drug candidates with favorable ADME properties. We have developed a novel physics-based method for fast computational modeling of passive permeation of diverse classes of molecules across lipid membranes. The method is based on heterogeneous solubility−diffusion theory and operates with all-atom 3D structures of solutes and the anisotropic solvent model of the lipid bilayer characterized by transbilayer profiles of dielectric and hydrogen bonding capacity parameters. The optimal translocation pathway of a solute is determined by moving an ensemble of representative conformations of the molecule through the dioleoyl-phosphatidylcholine (DOPC) bilayer and optimizing their rotational orientations in every point of the transmembrane trajectory. The method calculates (1) the membrane-bound state of the solute molecule; (2) free energy profile of the solute along the permeation pathway; and (3) the permeability coefficient obtained by integration over the transbilayer energy profile and assuming a constant size-dependent diffusivity along the membrane normal. The accuracy of the predictions was evaluated against experimental permeability coefficients measured in pure lipid membranes (for 78 compounds, R2 was 0.88 and rmse was 1.15 log units), PAMPA-DS (for 280 compounds, R2 was 0.75 and rmse was 1.59 log units), BBB (for 182 compounds, R2 was 0.69 and rmse was 0.87 log units), and Caco-2/MDCK assays (for 165 compounds, R2 was 0.52 and rmse was 0.89 log units).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Physics-Based Method for Modeling Passive Membrane Permeability and Translocation Pathways of Bioactive Molecules

Lomize

Pogozheva

2019

J. Chem. Inf. Model.

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“…As a new assessment dimension of reading literacy, affective element has become another important component in the sustainable development of one's reading literacy, which consists of a series of factors, concerning reading attitude (Kaderavek et al, 2014;Nootens et al, 2018;Lopes et al, 2022), reading anxiety (Katzir et al, 2018(Katzir et al, ), 10.3389/fpsyg.2023 Frontiers in Psychology 03 frontiersin.org reading motivation (Schiefele et al, 2012;Stutz et al, 2017;Wang and Gan, 2021;Wang and Jin, 2021), and reading habits. Thus, in recent years, a new trend of research has been aroused, on how to assess learners' affective impact on reading performance such as attitude and interest, showing the feature of diversified development of reading literacy assessment (Kell and Kell, 2014). Some researchers hold that students' reading performance is closely related to their cognitive and affective factors (Chiu et al, 2012).…”

Section: The Assessment Of Reading Literacymentioning

confidence: 99%

Development of the reading literacy questionnaire for EFL learners at primary schools

Kang

Shao

2023

Front. Psychol.

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Previous studies have indicated that there are a variety of factors influencing reading literacy assessment, including linguistic, cognitive, and affective factors, but little has been done on how to integrate these influential factors reasonably in a reading literacy instrument. As such, the purpose of this study is to develop and validate an English Reading Literacy Questionnaire (ERLQ) for English as foreign language (EFL) learners at the elementary level. The ERLQ was designed and revised through three rounds of validation with a sample of 784 pupils (Grades 3–6) in six primary schools from six provinces in China. Validity and reliability tests of the questionnaire were conducted with item analysis, Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), reliability test, and the analysis of criterion validity in SPSS 26.0 and AMOS 23.0. Results indicated that the revised ERLQ had high internal consistency, ranging from 0.729 to 0.823. The criterion validity of the ERLQ was supported by significant correlations to the Chinese Students’ English Rating Scale verified by the authoritative department, with a correlation coefficient of 0.871. The study shows that the revised questionnaire, with 3 dimensions of 14 items, has high reliability and validity, which can be used as an assessment instrument for the intended audience. It also suggests that modifications may be made for further use in other regions and countries, depending on the background information of the learners.

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Overview of Education in Indonesia

Sakhiyya,

Rahmawati

2024

Springer International Handbooks of Education

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Literacy and Language in East Asia

Cited by 9 publications

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Physics-Based Method for Modeling Passive Membrane Permeability and Translocation Pathways of Bioactive Molecules

Physics-Based Method for Modeling Passive Membrane Permeability and Translocation Pathways of Bioactive Molecules

Development of the reading literacy questionnaire for EFL learners at primary schools

Overview of Education in Indonesia

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