Literature review and evaluation of biomarkers, matrices and analytical methods for chemicals selected in the research program Human Biomonitoring for the European Union (HBM4EU)

Sabbioni, Gabriele; Castaño, Argelia; López, Marta Esteban; Göen, Thomas; Mol, Hans; Riou, Margaux; Tagne-Fotso, Romuald

doi:10.1016/j.envint.2022.107458

Cited by 17 publications

(15 citation statements)

References 297 publications

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“…10 This is especially true for blood protein adduct biomarkers (e.g., hemoglobin or albumin adducts), which reflect an individual's exposure history integrated over weeks to months. 12 Currently, urine is a preferred sampling matrix in field studies for many analytes due to its noninvasive nature and acceptability among study participants. 7 However, DBS sampling represents a fieldfriendly complement to urine sample collection with a high level of acceptability by study participants, 74−76 especially in settings where DBS sampling has been used for other purposes, such as for the monitoring of HIV antiretroviral treatment.…”

Section: ■ Discussionmentioning

confidence: 99%

“…10 Among the mycotoxins, aflatoxins, fumonisins, ochratoxins, deoxynivalenol (DON), and zearalenone (ZEA) pose the greatest threats to global health. 3,11 The European Human Biomonitoring initiative (HBM4 EU) recently labeled aflatoxin B1 (AFB 1 ), DON, and fumonisin B1 (FB 1 ) as "prioritized chemicals of concern" 12 and there is growing interest in monitoring and reducing mycotoxin exposure levels globally. 4 While much progress has been made in measuring aflatoxin exposure biomarkers to understand disease etiology and evaluate public health interventions to reduce exposures, 1,2 there remains a paucity of high-quality longitudinal epidemiologic data on human exposures to most mycotoxins and associated health risks, especially in children.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Mycotoxins may adversely affect human health and consequently should be incorporated into human biomonitoring (HBM) and exposomics studies . Among the mycotoxins, aflatoxins, fumonisins, ochratoxins, deoxynivalenol (DON), and zearalenone (ZEA) pose the greatest threats to global health. , The European Human Biomonitoring initiative (HBM4 EU) recently labeled aflatoxin B1 (AFB 1 ), DON, and fumonisin B1 (FB 1 ) as “prioritized chemicals of concern” and there is growing interest in monitoring and reducing mycotoxin exposure levels globally . While much progress has been made in measuring aflatoxin exposure biomarkers to understand disease etiology and evaluate public health interventions to reduce exposures, , there remains a paucity of high-quality longitudinal epidemiologic data on human exposures to most mycotoxins and associated health risks, especially in children. , Although much can be attributed to a lack of proper surveillance in many parts of the world, the surveillance mechanisms which exist primarily involve measurements of food contamination (i.e., food sampling) rather than measurements of human exposures (i.e., biological sampling).…”

Section: Introductionmentioning

confidence: 99%

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Advancing Global Health Surveillance of Mycotoxin Exposures using Minimally Invasive Sampling Techniques: A State-of-the-Science Review

Jacobson,

Bae,

Kler

et al. 2024

Environ. Sci. Technol.

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Mycotoxins are a heterogeneous group of toxins produced by fungi that can grow in staple crops (e.g., maize, cereals), resulting in health risks due to widespread exposure from human consumption and inhalation. Dried blood spot (DBS), dried serum spot (DSS), and volumetric tip microsampling (VTS) assays were developed and validated for several important mycotoxins. This review summarizes studies that have developed these assays to monitor mycotoxin exposures in human biological samples and highlights future directions to facilitate minimally invasive sampling techniques as global public health tools. A systematic search of PubMed (MEDLINE), Embase (Elsevier), and CINAHL (EBSCO) was conducted. Key assay performance metrics were extracted to provide a critical review of the available methods. This search identified 11 published reports related to measuring mycotoxins (ochratoxins, aflatoxins, and fumonisins) using DBS/DSS and VTS assays. Multimycotoxin assays adapted for DBS/DSS and VTS have undergone sufficient laboratory validation for applications in large-scale population health and human biomonitoring studies. Future work should expand the number of mycotoxins that can be measured in multimycotoxin assays, continue to improve multimycotoxin assay sensitivities of several biomarkers with low detection rates, and validate multimycotoxin assays across diverse populations with varying exposure levels. Validated low-cost and ultrasensitive minimally invasive sampling methods should be deployed in human biomonitoring and public health surveillance studies to guide policy interventions to reduce inequities in global mycotoxin exposures.

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Section: ■ Discussionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Advancing Global Health Surveillance of Mycotoxin Exposures using Minimally Invasive Sampling Techniques: A State-of-the-Science Review

Jacobson,

Bae,

Kler

et al. 2024

Environ. Sci. Technol.

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“…This is a quite specific area belonging to more medicinal than ecological tasks, so it is not included in this review. Such methods were described in detail in several reviews [ 14 , 15 , 16 ].…”

Section: Biological Methods Of Environmental Monitoringmentioning

confidence: 99%

Vibrational Spectroscopy as a Tool for Bioanalytical and Biomonitoring Studies

Pirutin

Jia²,

Yusipovich

et al. 2023

IJMS

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The review briefly describes various types of infrared (IR) and Raman spectroscopy methods. At the beginning of the review, the basic concepts of biological methods of environmental monitoring, namely bioanalytical and biomonitoring methods, are briefly considered. The main part of the review describes the basic principles and concepts of vibration spectroscopy and microspectrophotometry, in particular IR spectroscopy, mid- and near-IR spectroscopy, IR microspectroscopy, Raman spectroscopy, resonance Raman spectroscopy, Surface-enhanced Raman spectroscopy, and Raman microscopy. Examples of the use of various methods of vibration spectroscopy for the study of biological samples, especially in the context of environmental monitoring, are given. Based on the described results, the authors conclude that the near-IR spectroscopy-based methods are the most convenient for environmental studies, and the relevance of the use of IR and Raman spectroscopy in environmental monitoring will increase with time.

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“…In workers exposed to HDI, HDA was found after strong basic hydrolysis (e.g., 3 M NaOH, 100 °C, and 4 h) of urine and after strong acidic hydrolysis (e.g., 1.6 M H 2 SO 4 , 100 °C, and 16 h) of plasma . In all the studies applying strong acidic or basic hydrolysis conditions, − the chemical structure of the adducts before cleavage is unknown. There are only a few studies in which urine was treated under mild conditions.…”

Section: Introductionmentioning

confidence: 99%

New Method to Biomonitor Workers Exposed to 1,6-Hexamethylene Diisocyanate

Sabbioni

Pugh²

2022

Chem. Res. Toxicol.

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Isocyanates such as 1,6-hexamethylene diisocyanate (HDI), 4,4′-methylenediphenyl diisocyanate, and toluene diisocyanate are highly reactive compounds that have a variety of commercial applications, including manufacturing polyurethane foam, elastomers, paints, adhesives, coatings, insecticides, and many other products. Their primary route of occupational exposure is through inhalation. Due to their high chemical reactivity, they are toxic and have adverse effects at the cellular and subcellular levels, leading to irritative and immunological reactions associated with lung disease. High concentrations of isocyanates are strong respiratory irritants. Bronchial sensitization and asthma are among the major adverse clinical reactions associated with low-level chronic exposure to isocyanates. Albumin adducts have been linked to the mechanism of occupational asthma caused by isocyanates. Isocyanates react in vivo with albumin, which is recognized by the immune system. Albumin adducts of isocyanates trigger immune responses and are probably the antigenic basis for isocyanate asthma. Sensitization to isocyanates is the main pathway for adverse health effects. Therefore, markers for the biologically effective dose such as albumin adducts of HDI are needed. A new isocyanate adduct of HDI with lysine�N ε -[(6-amino-hexyl-amino)carbonyl]-lysine (HDI-Lys)�was synthesized and characterized by 1 H-NMR, 13 C-NMR, and mass spectrometry (MS). Appropriate internal standards�HDI-Lys-4,4′-5,5′-d 4 (HDI-d 4 -Lys) and N ε -[(7amino-heptyl-amino)carbonyl]-lysine (Hep-Lys)�were synthesized to establish a LC−MS/MS method for the analysis of HDI adducts in in vitro modified albumin and in workers. The presence of HDI-Lys was found after pronase digestion of albumin and confirmed by two independent chromatographic approaches: with a C8 reversed-phase column and with a hydrophilic interaction liquid chromatography column. Quantification was performed with positive electrospray ionization (ESI)−MS. The adduct peak found in vivo was confirmed with the less sensitive negative ESI−MS. In summary, these are new compounds and methods to determine isocyanate-specific adducts with albumin in workers exposed to HDI.

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Literature review and evaluation of biomarkers, matrices and analytical methods for chemicals selected in the research program Human Biomonitoring for the European Union (HBM4EU)

Cited by 17 publications

References 297 publications

Advancing Global Health Surveillance of Mycotoxin Exposures using Minimally Invasive Sampling Techniques: A State-of-the-Science Review

Advancing Global Health Surveillance of Mycotoxin Exposures using Minimally Invasive Sampling Techniques: A State-of-the-Science Review

Vibrational Spectroscopy as a Tool for Bioanalytical and Biomonitoring Studies

New Method to Biomonitor Workers Exposed to 1,6-Hexamethylene Diisocyanate

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