Literature review of outcomes and prevalence and case report of leiomyosarcomas and non-typical uterine smooth muscle leiomyoma tumors treated with uterine artery embolization

Kainsbak, Janne; Hansen, Estrid Stæhr; Dueholm, Margit

doi:10.1016/j.ejogrb.2015.05.018

Cited by 25 publications

(8 citation statements)

References 70 publications

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“…Besides benign leiomyomas and malignant leiomyosarcomas, uterine smooth muscle tumours include benign tumours with an unusual growth pattern, some of which may demonstrate metastatic potential [3,4].…”

Section: Introductionmentioning

confidence: 99%

Metastasising Leiomyoma of the Uterus with Pulmonary Involvement—Case Report

Maskey-Warzęchowska

Chojnowska

Ptaszyński

et al. 2017

Advances in Respiratory Medicine

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Benign metastasising leiomyoma (BML) is characterised by extrauterine smooth muscle tumours in women after surgical treatment for uterine leiomyoma. Usually manifested as solitary or multiple focal lesions in various organs, it imposes a scrutinous diagnostic work-up to exclude a malignant disease and requires confirmation in microscopic examination of the extrauterine focus. The authors present a case of a 56-year-old woman with BML manifesting as bilateral multiple pulmonary nodules, with a tentative diagnosis of a disseminated malignant disease of mesenchymal origin. The patient underwent multiple diagnostic tests, which excluded malignancy. The definite diagnosis was established after the microscopic reevaluation of an excised pulmonary nodule. The patient is monitored with chest magnetic resonance. BML should be considered in the differential diagnosis of multiple pulmonary nodules in asymptomatic women. Patients with BML require long-term monitoring, therefore the selected imaging method should not carry the risk of cumulative side effects.

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Section: Introductionmentioning

confidence: 99%

Metastasising Leiomyoma of the Uterus with Pulmonary Involvement—Case Report

Maskey-Warzęchowska

Chojnowska

Ptaszyński

et al. 2017

Advances in Respiratory Medicine

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“…In rare cases, LMS will be inadvertently embolized. Inadvertent UAE treatment of LMS does not seem to spread malignancy, but this approach may impair prognosis by delaying diagnosis (7).…”

Section: Differentiation Of Fibroids From Uterine Leiomyosarcomamentioning

confidence: 99%

“…Uterine sarcomas are rare tumors, accounting for less than 3% of all female genital tract malignancies and for approximately 8% of uterine malignancies (7,8). Leiomyosarcoma (LMS) is the most common histologic subtype of uterine sarcomas.…”

Section: Differentiation Of Fibroids From Uterine Leiomyosarcomamentioning

confidence: 99%

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Preprocedural MRI and MRA in planning fibroid embolization

Maciel¹,

Tang²,

Sahdev³

et al. 2017

Diagn Interv Radiol

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“…7 A misdiagnosis concerns not only radical treatment of fibroid tumors but also other therapeutic options such as uterine artery embolization and magnetic resonance imagingYguided focused ultrasound surgery. 8 Uterine sarcomas are rare tumors. The incidence rates are retrieved from retrospective data.…”

mentioning

confidence: 99%

European Society of Gynecological Oncology Statement on Fibroid and Uterine Morcellation

Halaška

Haidopoulos

Guyon

et al. 2016

Int J Gynecol Cancer

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Recently, there has been an intense discussion about the issue of fibroid and uterine morcellation in relation to the risk of unrecognized uterine sarcoma spread. Morcellation can negatively influence the prognosis of patients, and transecting the specimen into pieces prevents the pathologist from performing proper disease staging. Many societies have published their statements regarding this issue. The European Society for Gynecological Oncology has established a working group of clinicians involved in diagnostics and treatment of oncogynecological patients to provide a statement from the oncological point of view. Leiomyosarcomas and undifferentiated endometrial sarcomas have generally dismal prognosis, whereas low-grade endometrial stromal sarcomas and adenosarcomas have variable prognosis based on their stage. A focus on the detection of patients at risk of having a sarcoma should be mandatory before every surgery where morcellation is planned by evaluation of risk factors (African American descent, previous pelvic irradiation, use of tamoxifen, rapid lesion growth particularly in postmenopausal patients) and exclusion of patients with any suspicious ultrasonographic signs. Preoperative endometrial biopsy should be mandatory, although the sensitivity to detect sarcomas is low. An indication for myomectomy should be used only in patients with pregnancy plans; otherwise en bloc hysterectomy is preferred in both symptomatic and postmenopausal patients. Eliminating the technique of morcellation could lead to an increased morbidity in low-risk patients; therefore, after thorough preoperative evaluation and discussion with patients, morcellation still has its place in the armamentarium of gynecologic surgery.

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Literature review of outcomes and prevalence and case report of leiomyosarcomas and non-typical uterine smooth muscle leiomyoma tumors treated with uterine artery embolization

Cited by 25 publications

References 70 publications

Metastasising Leiomyoma of the Uterus with Pulmonary Involvement—Case Report

Metastasising Leiomyoma of the Uterus with Pulmonary Involvement—Case Report

Preprocedural MRI and MRA in planning fibroid embolization

European Society of Gynecological Oncology Statement on Fibroid and Uterine Morcellation

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