Lithium Action on Rat Phosphate Metabolism

Plenge, Per; Et, Mellerup; Oj, Rafaelsen

doi:10.1159/000468251

Cited by 20 publications

(7 citation statements)

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“…Furthermore, it was observed that lithium decreased the uptake of magnesium into bones. This de crease in bone uptake after lithium, has also been observed with respect to calcium (1) and phosphate (18); and the increase in serum magnesium is similar to the increase in serum calcium (1), whereas phosphate (18) is decreased after lithium administration.…”

Section: Discussionsupporting

confidence: 65%

“…The lithium effect on carbohydrate metabolism is followed by an increased uptake of phosphate into muscle in vivo as well as in vitro, and a decrease in serum phosphate; also incorporation of phosphate into bone is decreased after lithium (18). In bones, the phosphate ions are electrically neutralized -primar ily by calcium ions, but also about half of the total body magnesium is deposited in the bones.…”

Section: Discussionmentioning

confidence: 99%

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Lithium Effects on Magnesium Metabolism in Rats

Plenge

Oj³

1973

Int Pharmacopsychiatry

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Lithium Effects on Magnesium Metabolism in Rats

Plenge

Oj³

1973

Int Pharmacopsychiatry

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“…As discussed earlier (Plenge et al, 1971;Mellerup and Rafaelsen, 1975) we suggest that the changes in phosphate metabolism after lithium administration are secondary to a variety of changes in carbohydrate metabolism. The resulting uptake of phosphate into, especially, muscle and liver explains the decrease in serum phosphate, and is followed by decreased uptake or increased release of phosphate from the bones, which in turn may be accompanied by parallel changes in bone calcium and magnesium.…”

Section: Discussionsupporting

confidence: 58%

“…Animai experiments have shown that acute administration of lithium influenced calcium and magnesium metabolism {Mellerup et al, 1970; 1973), and that the observed changes may be secondary to the effect of lithium on phosphate and carbohydrate metabolism {Gotfredsen and Plenge et al, 1971 ;Mellerup and Rafaelsen, 1975). However, such initial changes may disappear during prolonged treatment, whereas other changes may be ob served only after lithium has been given for some time.…”

Section: Introductionmentioning

confidence: 99%

Lithium Effects on Magnesium, Calcium, and Phosphate Metabolism in Rats

Mellerup¹,

Plenge²

1976

Int Pharmacopsychiatry

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Rats were treated with lithium chloride for 8 weeks. At the last day of lithium administration, the animals were given radioactive calcium, magnesium, and phosphate. Electrolyte content and radioactivity were determined in serum, bone, muscle, liver and brain. Lithium led to an increase of inorganic phosphate in muscle and a decrease in serum. Uptake of radioactive phosphate was increased in muscle and liver but reduced in bone. The amount of magnesium in muscle and serum was increased in the lithium-treated rats, whereas the uptake of radioactive magnesium into bone was decreased. Uptake of radioactive calcium into bone was reduced, and radioactive calcium in serum was increased after lithium.

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“…(Endocrinology 94: 915, 1974) HPHE significance and mechanisms responsible •*-for the reported decrease in serum inorganic phosphorus, increase in serum total calcium, and decrease in the incorporation of ( 45 Ca) and ( 32 P) into bone following the intraperitoneal injection of a single large dose of lithium chloride (LiCl) to a rat are not known (1,2). Calcitonin, parathyroid hormone, and renal function per se do not appear to be responsible for the observed changes since the changes occur in the absence of the kidneys and the thyroid, and parathyroid glands.…”

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Lack of Effect of Chronic Lithium Chloride on Bone Composition and Metabolism¹

Henneman

Joshua

1974

Endocrinology

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Lithium chloride (LiCl, 1.43 ± 0.13 mEqA/day) was administered in distilled water to 13 adult female rats for 40 days; 6 rats served as controls. LiCl had no effect on the serum total calcium and inorganic phosphorus or on metaphyseal bone composition or collagen metabolism. There were no significant changes in the percentage bone wet weight of mineral salts, organic matrix, or fat and water; there were no changes in the content per unit wet weight of calcium, hydroxyproline, or DNA. There were no changes in the total amount of soluble collagen, the rate of collagen resorption under standardized conditions in vitro, or the rate of collagen formation. Serum lithium rose to 0.42 ± 0.10 mEq/1 and bone lithium content to 29/M-g/g wet weight.The data fail to demonstrate any effect of lithium on female rat bone composition or metabolism in doses which are many times the usual human prophylactic dose of 0.2-0.4 meq/k/day and administered under the experimental conditions described. (Endocrinology 94: 915, 1974) HPHE significance and mechanisms responsible •*-for the reported decrease in serum inorganic phosphorus, increase in serum total calcium, and decrease in the incorporation of ( 45 Ca) and ( 32 P) into bone following the intraperitoneal injection of a single large dose of lithium chloride (LiCl) to a rat are not known (1,2). Calcitonin, parathyroid hormone, and renal function per se do not appear to be responsible for the observed changes since the changes occur in the absence of the kidneys and the thyroid, and parathyroid glands. Because of this, the suggestion has been made that LiCl may have a direct effect on bone metabolism (1,2). Retention of lithium in bone following its chronic administration is in keeping with this suggestion (3). On the other hand, chronic administration in the rat of relatively non-toxic doses of LiCl has been shown to decrease proximal renal tubular reabsorption of calcium, phosphate, sodium, potassium, and uric acid (4,5) thereby increasing their renal excretion. The relation of these observations to bone metabolism and to changes in serum inorganic phosphorus and calcium is equally unclear.In view of the clinical use of chronic LiCl administration in certain manic-depressive disorders and the suggestive evidence that LiCl may modify bone calcium metabolism, the effect of chronic LiCl was studied in female rats. The data demonstrate that LiCl administered in sufficient doses to increase both serum and bone levels is not associated with any changes in bone collagen or calcium composition, bone resorption or collagen metabolism. Materials and MethodsDetails of all analytical techniques and procedures used have been published recently (6). Further details for methods in vitro have also been published (7,8,9).Nineteen female rats (Sprague Dawley, 150 g, 7 weeks old) were fed Purina Chow (2.5 meq sodium per day per rat) ad libitum. Six received distilled water and 13 received sequentially 0.005M lithium chloride (LiCl) for 7 days, 0.05M LiCl for 3 days (at which time they stopped drink...

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Lithium Action on Rat Phosphate Metabolism

Cited by 20 publications

References 4 publications

Lithium Effects on Magnesium Metabolism in Rats

Lithium Effects on Magnesium Metabolism in Rats

Lithium Effects on Magnesium, Calcium, and Phosphate Metabolism in Rats

Lack of Effect of Chronic Lithium Chloride on Bone Composition and Metabolism¹

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Lithium Action on Rat Phosphate Metabolism

Cited by 20 publications

References 4 publications

Lithium Effects on Magnesium Metabolism in Rats

Lithium Effects on Magnesium Metabolism in Rats

Lithium Effects on Magnesium, Calcium, and Phosphate Metabolism in Rats

Lack of Effect of Chronic Lithium Chloride on Bone Composition and Metabolism1

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Lack of Effect of Chronic Lithium Chloride on Bone Composition and Metabolism¹