Lithium as a prooxidant? A possible protective role  of selenium – in vitro study

Musik, Irena; Kiełczykowska, Małgorzata; Rajtar, Barbara; Świątek, Łukasz; Polz‐Dacewicz, Małgorzata; Kocot, Joanna

doi:10.26444/aaem/74473

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…The supplementation of Se to these chickens prevented negative changes in the levels of reduced glutathione (GSH), mitochondrial membrane potential, and Ca 2+ -ATPase activity induced by Cr in brain tissue [42]. Protective effects of Se were also described against lithium-provoked oxidative stress in FaDu and Vero cell lines [43]. In chickens, simultaneous administration of Se with lead (Pb) reduced the Pb level in serum and alleviated Pb-induced activation of the NF-κB pathway [44].…”

Section: Selenium and Its Health Effects In Humans And Animalsmentioning

confidence: 99%

The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature

Zwolak

2019

Biol Trace Elem Res

242

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Arsenic (As) and cadmium (Cd) are elements arousing major public health concerns associated with environmental pollution, high toxicity potential, and carcinogenic nature. However, selenium (Se) at low doses and incorporated into enzymes and proteins has antioxidant properties and protects animals and humans from the risk of various diseases. It also has an exceptionally narrow range between necessary and toxic concentrations, which is a well-known hindrance in its use as a dietary supplement. The present article aims to update and expand the role of Se in As and Cd toxicity discussed in our earlier paper. In general, recent reports show that Se, regardless of its form (as selenite, selenomethionine, nanoSe, or Se from lentils), can reduce As- or Cd-mediated toxicity in the liver, kidney, spleen, brain, or heart in animal models and in cell culture studies. As was suggested in our earlier review, Se antagonizes the toxicity of As and Cd mainly through sequestration of these elements into biologically inert complexes and/or through the action of Se-dependent antioxidant enzymes. An increase in the As methylation efficiency is proposed as a possible mechanism by which Se can reduce As toxicity. However, new studies indicate that Se may also diminish As or Cd toxicity by activation of the Nrf2 pathway. In addition, this paper discusses possible signs of Se toxic effects, which may be a challenge for its future use in the therapy of As and Cd poisoning and provide future directions to address this issue.

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Section: Selenium and Its Health Effects In Humans And Animalsmentioning

confidence: 99%

The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature

Zwolak

2019

Biol Trace Elem Res

242

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“…18 Again, results in rat studies on TAS and antioxidant enzymes superoxide dismutase, glutathione peroxidase and catalase in cell culture differ. 19,20 However, a literature review did not reveal any research related to TOS and OSI in the kidneys in lithium damage, which shows the actual oxidative stress state. [13][14][15][16] In the current study, we observed that TOS values in both plasma and tissue increased with chronic lithium exposure.…”

Section: Discussionmentioning

confidence: 98%

Protective effect of metformin on lithium-induced nephrogenic diabetes insipidus: An experimental study in rats

Taş¹,

Sancak²

2021

Adv Clin Exp Med

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Background. Lithium is widely used in the treatment of bipolar disorders and may lead to nephrogenic diabetes insipidus (NDI), following long-term treatment. Metformin is considered the preferred initial therapy for patients with type 2 diabetes mellitus (T2D). Objectives.To investigate the protective effect of metformin on the kidney damage caused by lithium administration. Materials and methods.Using an animal model of chronic lithium-induced NDI, rats were divided into 4 groups: sham, metformin, lithium, and lithium + metformin. The effects of these treatments were examined using serum electrolytes, blood and tissue total antioxidant status, total oxidant status, the oxidative stress index, urine and blood osmolality, and tissue aquaporin-2 (AQP2) levels. Additionally, histopathological changes, including congestion, hydropic swelling, tubular necrosis, tubular atrophy, and Bowman's capsule dilatation, were evaluated. The total histopathological score was obtained by summing the scores for each pathological finding.Results. In the lithium group, biochemical variables indicating NDI, including sodium, chloride and blood osmolality, increased, and urine osmolality decreased, compared to the sham group. With metformin treatment, the blood osmolality decreased from 328. 17 mOsm/kg to 306.33 mOsm/kg, and urine osmolality increased from 349.67 mOsm/kg to 754.50 mOsm/kg (p = 0.004 and p = 0.001, respectively). Tissue AQP2 levels decreased with lithium administration but stabilized with metformin treatment. Additionally, in comparison to the lithium group, the total histopathological score in the metformin group declined from 8.0 to 2.0 (p = 0.002).Conclusions. Metformin may help protect the kidneys from lithium-induced NDI through the AQP2 regulating effect and a reduction in oxidative stress.

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“…Consistent with our results, lithium significantly reduced the activity of enzymatic antioxidants in the testes and heart, as well as FaDu (ATCC HTB-43) and Vero (ECACC No. 84113001) cell lines [12,55]. Considering the low amounts of the sperm cytoplasm and the insufficient levels of antioxidants in the spermatozoa, these cells are very sensitive to the oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Coexposure of Silymarin with Lithium Chloride Preserves Human Sperm Quality: A Useful Approach to Reduce Oxidative Damages

Nasimi,

Momeni,

Etemadi

et al. 2023

Andrologia

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Lithium, a common component in various mood-stabilizing drugs, induces adverse effects on spermatozoa and human fertility. Oxidative stress, as a possible mechanism involved in lithium toxicity, can be reversed using antioxidants. Therefore, in this study, the effects of silymarin as a potent antioxidant were evaluated on human spermatozoa treated with lithium. Human spermatozoa were divided into five groups: (1) spermatozoa at 0 min, (2) spermatozoa at 180 min (control group), (3) spermatozoa treated with lithium chloride (500 μM) for 180 min, (4) spermatozoa were treated with silymarin (100 μM) + lithium chloride (500 μM) for 180 min, and (5) spermatozoa treated with silymarin (100 μM) for 180 min. Sperm motility and viability, the levels of malondialdehyde (MDA) and ferric reducing antioxidant power (FRAP), and the activity of antioxidant enzymes (catalase, superoxide dismutase, glutathione peroxidase) were evaluated in these groups. The results showed that sperm motility and viability significantly ( p < 0.001 ) decreased in the group treated with lithium. In addition, a significant increase ( p < 0.001 ) was observed in MDA levels, while FRAP amount and the activity of antioxidant enzymes decreased significantly ( p < 0.001 ) in this group. Interestingly, these results were significantly ( p < 0.001 ) reversed in the group treated with silymarin + lithium. The finding of the present study showed that oxidative stress plays a crucial role in lithium toxicity in human spermatozoa, and the coapplication of silymarin as a potent antioxidant with lithium can protect human sperm against oxidative stress-induced damage.

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Lithium as a prooxidant? A possible protective role of selenium – in vitro study

Cited by 6 publications

References 26 publications

The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature

The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature

Protective effect of metformin on lithium-induced nephrogenic diabetes insipidus: An experimental study in rats

In Vitro Coexposure of Silymarin with Lithium Chloride Preserves Human Sperm Quality: A Useful Approach to Reduce Oxidative Damages

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